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Tris(2-aminoethyl)amine

Tris(2-aminoethyl)amine Structure
Tris(2-aminoethyl)amine structure
CAS No.
4097-89-6
Chemical Name:
Tris(2-aminoethyl)amine
Synonyms
TREN;TAEA;tri(2-aminoethyl)amine;tris(aminoethyl)amine;trenhp;Tris(2-aminoethyL;Tris(2-aMinoethyl)a;Trientine Impurity 5;Triaminotriethyl-amine;N1,N1-Bis(2-aminoethyl)
CBNumber:
CB0235693
Molecular Formula:
C6H18N4
Molecular Weight:
146.23
MDL Number:
MFCD00008177
MOL File:
4097-89-6.mol
MSDS File:
SDS
Last updated:2026-01-13 11:13:15
Product description Number Pack Size Price
Tris(2-aminoethyl)amine 96% 225630 10ml $56.2
Tris(2-aminoethyl)amine 96% 225630 100ml $275
Tris(2-aminoethyl)amine >98.0%(T) T1243 5mL $46
Tris(2-aminoethyl)amine >98.0%(T) T1243 25mL $135
2,2',2''-Triaminotriethylamine, min. 98% TREN 07-2400 10g $37
More product size
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Tris(2-aminoethyl)amine Properties

Melting point -16 °C
Boiling point 114 °C/15 mmHg (lit.)
Density 0.976 g/mL at 20 °C (lit.)
vapor density 5 (vs air)
vapor pressure 0.02 mm Hg ( 20 °C)
refractive index n20/D 1.497(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility Chloroform (Sparingly), DMSO (Slightly)
form saline suspension
pka 10.00±0.10(Predicted)
Specific Gravity 0.977
color Clear yellow
Water Solubility Miscible with water.
Sensitive Hygroscopic
BRN 1739626
Stability Stable. Hygroscopic. Absorbs carbon dioxide from the air. Incompatible with strong acids, strong oxidizing agents.
InChI 1S/C6H18N4/c7-1-4-10(5-2-8)6-3-9/h1-9H2
InChIKey MBYLVOKEDDQJDY-UHFFFAOYSA-N
SMILES NCCN(CCN)CCN
CAS DataBase Reference 4097-89-6(CAS DataBase Reference)
FDA UNII 3GY3QSG6H5
EPA Substance Registry System 1,2-Ethanediamine, N,N-bis(2-aminoethyl)- (4097-89-6)
UNSPSC Code 12162002
NACRES NA.23

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06
Signal word  Danger
Hazard statements  H301-H310-H314
Precautionary statements  P270-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  T,Xi
Risk Statements  22-24-34-36/37/38-10
Safety Statements  26-36/37/39-45-16
RIDADR  UN 2922 8/PG 2
WGK Germany  3
RTECS  KH8587082
F  3-10-23
TSCA  TSCA listed
HazardClass  6.1
PackingGroup  II
HS Code  29211990
Storage Class 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials
Hazard Classifications Acute Tox. 2 Dermal
Acute Tox. 3 Oral
Skin Corr. 1B
Toxicity mouse,LD50,oral,1800mg/kg (1800mg/kg),LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSIONBEHAVIORAL: ATAXIAGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA","Spravochnik po Toksikologii i Gigienicheskim Normativam Vol. -, Pg. 223, 1999.
Limited Quantities 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
NFPA 704
1
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Tris(2-aminoethyl)amine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 225630 Tris(2-aminoethyl)amine 96% 4097-89-6 10ml $56.2 2025-07-31 Buy
Sigma-Aldrich 225630 Tris(2-aminoethyl)amine 96% 4097-89-6 100ml $275 2025-07-31 Buy
TCI Chemical T1243 Tris(2-aminoethyl)amine >98.0%(T) 4097-89-6 5mL $46 2025-07-31 Buy
TCI Chemical T1243 Tris(2-aminoethyl)amine >98.0%(T) 4097-89-6 25mL $135 2025-07-31 Buy
Strem Chemicals 07-2400 2,2',2''-Triaminotriethylamine, min. 98% TREN 4097-89-6 10g $37 2024-03-01 Buy
Product number Packaging Price Buy
225630 10ml $56.2 Buy
225630 100ml $275 Buy
T1243 5mL $46 Buy
T1243 25mL $135 Buy
07-2400 10g $37 Buy

Tris(2-aminoethyl)amine Chemical Properties,Uses,Production

Chemical Properties

Colorless liquid

Uses

Tris(2-aminoethyl)amine is a tetradentate chelating ligand and forms stable complexes with transition metals. It is also used as a carbon dioxide absorbent. Further, it acts as a reagent for cleavage of the fluorenylmethyloxycarbonyl (Fmoc) group in peptide synthesis. It reacts with aryl isocyanates and isothiocyanates to give tris-urea and -thiourea derivatives.

Definition

ChEBI: Tris(2-aminoethyl)amine is a tetramine.

General Description

Tris(2-aminoethyl)amine (TREN) is a water soluble tripodal ligand that is majorly used in co-ordination chemistry. It has three aminoethylgroups that attach with the surface atoms to provide a scaffold assembly.

Reactivity Profile

Tris(2-aminoethyl)amine (tren) is a commercially available tripodal amine, which has found wide application as a ligand in the preparation of metal complexes. Due to the tripodal arrangement of donor atoms, tren and various N-functionalised derivatives have been commonly employed in the preparation of trigonal bipyramidal metal complexes. More elaborate or extended tren ligands have been formed via substitution or condensation reactions with aldehydes. Metal complexes prepared therefrom have been employed in catalysis and oxygen binding studies. They have also been used to stabilise redox active oxoanions, such as thiosulfate, and to prepare cyano-bridged heteropolynuclear clusters with ferromagnetic properties. Less well explored are aryl-substituted tren ligand structures. However, some have been employed in the formation of transition metal amido complexes, which have been demonstrated to act as catalysts in dinitrogen reduction (Mo V and Cr complexes) and which have been tested in alkene epoxidation reactions (Fe and Mn complexes). Aryl-substituted tren-based ligands are generally synthesised via aryl substitution reactions using commercially available ArF compounds in 28– 99% yields. A different pathway to these aryl-substituted tren compounds involves Pd-mediated aromatic coupling, limited to commercially available ArBr compounds, affording the products 27–90% yields. More extended tren structures have been prepared via a two-step synthesis of the starting ArBr compound followed by Pd-mediated aromatic coupling in lower but acceptable overall yields of 36–45%. Given the versatility and demonstrated utility of these ligands, considerable benefit would be derived from new synthetic strategies that would broaden the range of accessible aryl-substituted tren ligands[2].

Hazard

A poison by ingestion and skin contact.

Safety Profile

A poison by ingestion and skin contact. When heated to decomposition it emits toxic vapors of NOx.

Purification Methods

For a separation from a mixture containing 62% TRIEN, see entry under triethylenetetramine. Also purify it by conversion to the hydrochloride (see below), recrystallise it and regenerate the free base [Xie & Hendrickson J Am Chem Soc 109 6981 1987]. [Beilstein 4 H 256, 4 II 695, 4 III 545, 4 IV 1250.]

References

[1] Bengang Zhang. “Highly Branched Tannin-Tris(2-aminoethyl)amine-Urea Wood Adhesives.” Polymers 15 4 (2023).
[2] Ann Almesker . “One-pot synthesis of tripodal tris(2-aminoethyl)amine derivatives from seven molecular components.” Tetrahedron Letters 50 16 (2009): Pages 1847-1850.

Tris(2-aminoethyl)amine synthesis

817-09-4
4097-89-6
Synthesis of Tris(2-aminoethyl)amine from TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE

Tris(2-aminoethyl)amine Preparation Products And Raw materials

Raw materials

Congo Red Sodium hypochlorite Ammonium hydroxide Acrylamide 1,2-Dichloroethane
Hydrochloric acid Methanol Sodium hydroxide TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE

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Preparation Products

Tri(2-Fmoc-aminoethyl) amine

Tris(2-aminoethyl)amine Suppliers

Global( 238)Suppliers
Supplier Tel Email Country ProdList Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd 		0086-19817745290; +8619817745290 bd@blocksynth.com China 5661 58
HANGZHOU HAILAN CHEMICAL CO.,LTD.
+86-57156122185 +86-15967590394 sales@hailan-chem.com China 395 58
Beijing CosmicKoda Chemical Technology Co.,Ltd
8615311061293 15311061293 JeanWangCosmicKoda@outlook.com China 49 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 +86-18192627656 1059@dideu.com China 3589 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21597 55
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29831 58
Zhejiang ZETian Fine Chemicals Co. LTD 		+8618957127338 stella@zetchem.com China 2994 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Supplier Advantage
Blocksynth Pharmaceutical Technology Co.,Ltd 		58
HANGZHOU HAILAN CHEMICAL CO.,LTD.
58
Beijing CosmicKoda Chemical Technology Co.,Ltd
58
Shaanxi Dideu Medichem Co. Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing Finetech Chemical Co., Ltd. 		55
career henan chemical co 		58
Zhejiang ZETian Fine Chemicals Co. LTD 		58
CONIER CHEM AND PHARMA LIMITED 		58

Related articles

View Lastest Price from Tris(2-aminoethyl)amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
TRIS(2-AMINOETHYL)AMINE pictures 2026-01-30 TRIS(2-AMINOETHYL)AMINE
4097-89-6
 US $500.00 / bag 1bag 0.99 1TON HANGZHOU HAILAN CHEMICAL CO.,LTD.
Tris(2-aminoethyl)amine pictures 2025-12-12 Tris(2-aminoethyl)amine
4097-89-6
 US $1.00-4.00 / KG 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
TRIS(2-AMINOETHYL)AMINE pictures 2025-12-01 TRIS(2-AMINOETHYL)AMINE
4097-89-6
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

Tris(2-aminoethyl)amine Spectrum

TRIS(2-AMINOETHYL)AMINE(4097-89-6)MSTRIS(2-AMINOETHYL)AMINE(4097-89-6)1HNMRTRIS(2-AMINOETHYL)AMINE(4097-89-6)13CNMRTRIS(2-AMINOETHYL)AMINE(4097-89-6)IR1TRIS(2-AMINOETHYL)AMINE(4097-89-6)Raman

4097-89-6(Tris(2-aminoethyl)amine)Related Search:

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2,8,9-TRIMETHYL-2,5,8,9-TETRAAZA-1-PHOSPHABICYCLO[3.3.3]UNDECANE CYCLEN-GLYOXAL TRIS(2-AMINOETHYL)AMINE TRIS(2-AMINOETHYL)AMINE POLYMER-BOUND,TRIS(2-AMINOETHYL)AMINE, POLYMER-SUPPORTED Ethylenediamine
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tris(aminoethyl)amine tris(beta-aminoethyl)amine 2,2',2''-Triaminotriethylamine,97%TREN 2,2'',2 -TRIAMINOTRIETHYLAMINE TREN 2,2μ,2μμ-Nitrilotriethylamine, 2,2μ,2μμ-Triaminotriethylamine, TAEA 2,2',2''-Nitrilotris(ethane-1-amine) 2,2',2''-Nitrilotrisethanamine Tris(2-aminoethyl)amine ,95% Tris(2-aMinoethyl)aMine, 96% 100ML Tris(2-aMinoethyl)aMine, 96% 5ML Tris(2-aminoethyl)amine,96% Tris(2-aMinoethyl)a Tris(2-aMinoethyl)aMine 96% N1,N1-Bis(2-aminoethyl) TAEA TRIS(2-AMINOETHYL)AMINE TREN 2,2',2''-TRIAMINOTRIETHYLAMINE 2,2',2''-NITRILOTRIETHYLAMINE N1,N1-Bis-(2-amino-ethyl)-ethane-1,2-diamine nitrilotris(ethylamine) trenhp tri(2-aminoethyl)amine Triaminotriethyl-amine 2,2',2''-Triaminotriethylamine, min. 98% TREN 2,2’,2’’-nitrilotris(ethylamine) 2,2’,2’’-triaminotris(ethylamine) 4-(2-Aminoethyl)diethylene triamine 4-(2-aminoethyl)-diethylenetriamin 4-(2-Aminoethyl)diethylenetriamine beta,beta’,beta’’-triaminotriethylamine Tris(2-aminoethyL 1,2-Ethanediamine, N1,N1-bis(2-aminoethyl)- Trientine Impurity 5 Tris(2-aminoethyl)amine, 98+%, 4097-89-6 C6H18N4 NCH2CH2NH23 NH2CH2CH23N Building Blocks Nitrogen Compounds Organic Building Blocks Polyamines