3-Fluoro-5-hydroxybenzeneboronic acid
- CAS No.
- 871329-82-7
- Chemical Name:
- 3-Fluoro-5-hydroxybenzeneboronic acid
- Synonyms
- 3-Borono-5-fluorophenol;(3-Fluoro-5-hydroxyphenyl);3-Fluoro-5-hydroxybenzeneboronic;3-FLUORO-5-HYDROXYPHENYLBORONIC ACID;3-Fluoro-5-hydroxybenzeneboronic acid;B-(3-Fluoro-5-hydroxyphenyl)boronic acid;Boronic acid, B-(3-fluoro-5-hydroxyphenyl)-;3-Fluoro-5-hydroxyphenylboronic Acid (contains varying amounts of Anhydride);3-Fluoro-5-hydroxybenzeneboronic Acid (contains varying amounts of Anhydride)
- CBNumber:
- CB0235875
- Molecular Formula:
- C6H6BFO3
- Molecular Weight:
- 155.92
- MDL Number:
- MFCD07363778
- MOL File:
- 871329-82-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 54-62 |
|---|---|
| Boiling point | 380.0±52.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 7.23±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C6H6BFO3/c8-5-1-4(7(10)11)2-6(9)3-5/h1-3,9-11H |
| InChIKey | RMBFBZIEXCTPDB-UHFFFAOYSA-N |
| SMILES | B(C1=CC(O)=CC(F)=C1)(O)O |
| CAS DataBase Reference | 871329-82-7 |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HS Code | 2931900090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
3-Fluoro-5-hydroxybenzeneboronic acid price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS007717 | 3-fluoro-5-hydroxybenzeneboronic acid AldrichCPR | 871329-82-7 | 250MG | $197 | 2026-04-30 | Buy |
| TCI Chemical | F0954 | 3-Fluoro-5-hydroxyphenylboronic Acid (contains varying amounts of Anhydride) | 871329-82-7 | 1g | $123 | 2026-04-30 | Buy |
| Activate Scientific | AS44090 | (3-Fluoro-5-hydroxyphenyl)boronic acid 98% | 871329-82-7 | 1g | $31 | 2026-06-04 | Buy |
| Activate Scientific | AS44090 | (3-Fluoro-5-hydroxyphenyl)boronic acid 98% | 871329-82-7 | 5g | $136 | 2026-06-04 | Buy |
| Activate Scientific | AS44090 | (3-Fluoro-5-hydroxyphenyl)boronic acid 98% | 871329-82-7 | 25g | $417 | 2026-06-04 | Buy |
3-Fluoro-5-hydroxybenzeneboronic acid Chemical Properties, Uses, Production
Uses
suzuki reaction
Uses
3-Fluoro-5-hydroxybenzeneboronic acid is used as pharmaceutical intermediate.
Synthesis
609807-25-2
871329-82-7
Under nitrogen protection, (3-fluoro-5-methoxyphenyl)boronic acid (500 mg, 2.942 mmol) was dissolved in dichloromethane (15 mL) and cooled to 0°C. A dichloromethane solution of 1 M boron tribromide (14.7 mL, 14.7 mmol) was slowly added dropwise. The reaction mixture was stirred at room temperature for 3 h. The progress of the reaction was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was concentrated under reduced pressure. Water (15 mL) was added to the residue and the pH was adjusted to 2 with 1 M aqueous hydrochloric acid. the product was extracted with ethyl acetate (2 x 25 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give (3-fluoro-5-hydroxyphenyl)boronic acid (430 mg) as an off-white solid.
References
[1] Patent: WO2015/58084, 2015, A1. Location in patent: Paragraph 0222
3-Fluoro-5-hydroxybenzeneboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Qihong Pharmaceutical Technology Co., Ltd. | 13482681346 18117455885 | qihongchem@163.com | China | 8731 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
View Latest Price from 3-Fluoro-5-hydroxybenzeneboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
871329-82-7
|
$1.00 | 1KG | 97%-99% | 1kg; 5kg; 100kg | Career Henan Chemical Co |
-
- 3-FLUORO-5-HYDROXYBENZENEBORONIC ACID
871329-82-7
- $1.00
- 97%-99%
- Career Henan Chemical Co
871329-82-7 (3-Fluoro-5-hydroxybenzeneboronic acid) Related Search:
1of4
