4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid
- CAS No.
- 128293-64-1
- Chemical Name:
- 4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid
- Synonyms
- Boc-Im-OH;BOC-NH(4)-MEIMD-(2)-OH;4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole;4-(BOC-AMINO)-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLIC ACID;4-[N-BOC-Amino]-1-methyl-1H-imidazol-2-carboxylic acid;4-[(T-BUTOXYCARBONYL)AMINO]-1-METHYLIMIDAZOLE-2-CARBOXYLIC ACID;4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic acid≥ 98% (HPLC);4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid;4-{[(tert-butoxy)carbonyl]amino}-1-methylimidazole-2-carboxylic acid;'4-((tert-Butoxycarbonyl)amino)-1-methyl-1H-imidazole-2-carboxylic acid'
- CBNumber:
- CB0241294
- Molecular Formula:
- C10H15N3O4
- Molecular Weight:
- 241.24
- MDL Number:
- MFCD03093495
- MOL File:
- 128293-64-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 43-36/37/38 |
| Safety Statements | 36/37-36/37/39-28-3 |
| HS Code | 29332900 |
4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B6350 | 4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic Acid | 128293-64-1 | 250MG | $115 | 2026-04-30 | Buy |
| TCI Chemical | B6350 | 4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic Acid | 128293-64-1 | 1G | $288 | 2026-04-30 | Buy |
| Usbiological | 266606 | 4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic acid ≥95% | 128293-64-1 | 250mg | $233 | 2026-06-03 | Buy |
| Usbiological | 266606 | 4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic acid ≥95% | 128293-64-1 | 1g | $541 | 2026-06-03 | Buy |
| Usbiological | 266606 | 4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic acid ≥95% | 128293-64-1 | 5g | $1409 | 2026-06-03 | Buy |
4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White to greyish white solid
Uses
4-(Boc-amino)-1-methyl-1H-imidazole-2-carboxylic Acid is used in the synthesis of polyamides containing imidazole and pyrrole amino acids. It is also used to prepare distamycin A analogs as DNA binding agents.
Synthesis
24424-99-5
128293-62-9
128293-64-1
GENERAL STEPS: Ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (0.38 g) and N,N-diisopropylethylamine (2 mL) were dissolved in N,N-dimethylformamide (8 mL) under dry conditions. Subsequently, di-tert-butyl dicarbonate (0.7 mL) was slowly added to this solution and the reaction mixture was stirred at 60 °C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and diluted by adding saturated sodium chloride solution (6 mL) and ether (6 mL). The organic layer was separated and washed sequentially with 10% aqueous citric acid solution, saturated sodium chloride solution, saturated sodium bicarbonate solution and saturated sodium chloride solution (10 mL each). The washed ether layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent. To the residue was added a methanol solution of 1 M sodium hydroxide (5 mL) and hydrolyzed with stirring at 60 °C for 1 hour. Upon completion of hydrolysis, the reaction mixture was cooled to 0 °C and the pH was adjusted to 2 with 1 M hydrochloric acid, at which point a white gel-like precipitate was formed. The precipitate was collected by gravity filtration, washed with water at pH=6 and subsequently freeze-dried to give 4-tert-butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid as a white powder. Yield: 0.41 g, 76% yield.1H NMR (DMSO-d6) δ: 9.45 (broad single peak, 1H, NH), 7.21 (broad single peak, 1H), 3.86 (single peak, 3H), 3.67 (broad single peak, 1H, OH), 1.40 (single peak, 9H).
References
[1] Patent: WO2005/33077, 2005, A1. Location in patent: Page/Page column 54
4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| Shanghai Raise Chemical Technology Co.,Ltd | 15026594951 | rs@raise-chem.com | China | 4905 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 4-tert-Butoxycarbonylamino-1-methyl-1H-imidazole-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-01 | 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLIC ACID
128293-64-1
|
$1.00 | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 4-TERT-BUTOXYCARBONYLAMINO-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLIC ACID
128293-64-1
- $1.00
- 99%
- Career Henan Chemical Co
