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ChemicalBook >> CAS DataBase List >>(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Structure
(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide structure
CAS No.
439687-69-1
Chemical Name:
(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide
Synonyms
Nelivaptan;NB-415;SSR 149415;SSR 149415 - Nelivaptan;Nelivaptan(SSR-149,415);(2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide;(2S,4R)-1-((R)-5-Chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxoindolin-3-yl)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide;(2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide;2-PYRROLIDINECARBOXAMIDE, 1-[(3R)-5-CHLORO-1-[(2,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-(2-METHOXYPHENYL)-2-OXO-1H-INDOL-3-YL]-4-HYDROXY-N,N-DIMETHYL-, (2S,4R)-;(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide
CBNumber:
CB02448473
Molecular Formula:
C30H32ClN3O8S
Molecular Weight:
630.11
MDL Number:
MFCD06199090
MOL File:
439687-69-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:48:00
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(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Properties

Boiling point 799.7±70.0 °C(Predicted)
Density 1.414±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility 63.01mg/ml in DMSO; 63.01mg/ml in ethanol
pka 14.14±0.40(Predicted)
form Solid
color White to off-white
FDA UNII 3TY57MQ4OA
UNSPSC Code 12352200
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Warning
Hazard statements  H373
Precautionary statements  P260-P314-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth PSA68769 SSR 149415 439687-69-1 25mg $877 2026-06-04 Buy
Biosynth PSA68769 SSR 149415 439687-69-1 50mg $1403.5 2026-06-04 Buy
Biosynth PSA68769 SSR 149415 439687-69-1 100mg $2246 2026-06-04 Buy
ChemScene CS-0002429 Nelivaptan 99.89% 439687-69-1 1mg $97 2026-06-04 Buy
ChemScene CS-0002429 Nelivaptan 99.89% 439687-69-1 5mg $200 2026-06-04 Buy
Product number Packaging Price Buy
PSA68769 25mg $877 Buy
PSA68769 50mg $1403.5 Buy
PSA68769 100mg $2246 Buy
CS-0002429 1mg $97 Buy
CS-0002429 5mg $200 Buy

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Chemical Properties,Uses,Production

Uses

SSR 149415 is a vasopressin V1b receptor antagonist.

Biological Activity

SSR149415 is an orally active, selective vasopressin V1b receptor antagonist (human/r at Ki in nM = 1.5/1.3/V1b, 91/1050/V1a, 1412/2897/V2, 174/270/OT) th at inhibits 30 nM AVP-induced Ca2+ response in human and r at V1b CHO transfectants (Ki = 1.26/2.0 nM). SSR149415 suppresses AVP-mediated physiological responses in vivo, including corticotropin secretion (1-30 mg/kg p.o. or i.p. in rats) upon exogenous AVP administration (0.3 μg/kg alone or 0.03 μg/kg with 0.1 μg corticoliberin/kg via i.v.), restraint stress-Induced corticotropin secretion (EC50 = 10 mg/kg i.p. in rats), and in a murine model of anxiety (four-plate test; 1-10 mg/kg i.p. or 3-10 mg/kg p.o. acute or 10 mg/kg/day p.o.).

in vivo

Nelivaptan (1-30 mg/kg; 30 min i.p. or 2 h p.o. before an exogenous AVP injection) inhibits exogenous AVP-induced increase in plasma corticotropin in Sprague-Dawley rats[1].
Nelivaptan (1-10 mg/kg; p.o.; 1, 2, 3, 4, and 6 h before the AVP challenge) produces powerful dose-dependent inhibition of the corticotropin increase in response to exogenous AVP plus corticotropin-releasing factor (CRF) in Sprague-Dawley rats[1].
Nelivaptan (1-10 mg/kg; i.p. 30 min or 60 min before test; or p.o. for 7 days) displays anxiolytic-like activity after acute and 7-day repeated administrations in male NMRI mice [1].
Nelivaptan (30 mg/kg; i.p.; daily for two weeks) retains efficacy in reducing both measured indices of depression-like behavior (learned helplessness and anhedonia), even when neurogenesis is blocked in male Wistar rats with chronic mild stress[2].

Animal Model:Male Wistar rats (300-400 g, aged 3 months) with chronic mild stress[2]
Dosage:30 mg/kg
Administration:Intraperitoneal injection (i.p.); daily for two weeks
Result:Chronic administration reversed learned helplessness and anhedonia even when methylazoxymethanol (MAM) was administered.
Attenuated these depressive-like behaviors after 1 week.
Restored the density of Ki-67-positive cells to control levels.
Animal Model:Male Sprague-Dawley CD rats (275-300 g)[1]
Dosage:1, 3, 10, 30 mg/kg
Administration:Intraperitoneal injection (i.p.) or Oral gavage (p.o.); 30 min i.p. or 2 h p.o. before an exogenous AVP injection
Result:Antagonized AVP-induced corticotropin secretion in a dose-dependent manner by both intraperitoneal and oral routes.
The inhibition was significant from 10 mg/kg p.o. and 3 mg/kg i.p. upwards.
The inhibitory action lasted significantly for more than 2 h at 10 mg/kg i.p. and up to 4 h at 10 mg/kg p.o..
Had no effect on basal corticotropin plasma levels up to 30 mg/kg p.o..
Animal Model:Male Sprague-Dawley CD rats (275-300 g)[1]
Dosage:1, 3, 10 mg/kg
Administration:Oral gavage (p.o.); 1, 2, 3, 4, and 6 h before the AVP challenge (10 mg/kg)
Result:Produced powerful dose-dependent inhibition of the corticotropin increase in response to exogenous AVP plus corticoliberin; the effect was significant from the dose of 3 mg/kg p.o.. Complete blockade was achieved at 10 mg/kg.
Showed a fast onset of action, the inhibitory effect was maximal at 1 h after administration.
The inhibitory effect on corticotropin secretion lasted significantly more than 4 h, demonstrating a long-lasting oral effect in a specific V1b-related model.
Animal Model:Male NMRI mice (20 g)[1]
Dosage:1, 3, 10 mg/kg
Administration:Intraperitoneal injection (i.p.) or Oral gavage (p.o.); i.p. (1, 3, 10 mg/kg) 30 min or 60 min befeore; p.o. (10 mg/kg) for 7 days,
Result:In the acute experiments, i.p. and p.o. compound increased the number of punished crossings showing marked anxiolytic effects.
Post hoc analysis revealed that these effects reached statistical significance from 3 mg/kg p.o. and i.p.
The anxiolytic-like activity was still significantly maintained when given repeatedly at 10 mg/kg p.o. for 7 days.
The oral time course of the anxiolytic-like action performed at 10 mg/kg indicated that effects lasted for more than 4 h.

storage

Store at -20°C

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Preparation Products And Raw materials

Raw materials

Preparation Products

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Suppliers

Global( 26)Suppliers
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Sichuan Changdexiangshun Co., Ltd. 13989459766;18781211904 348632238@qq.com China 176 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q meishipharma@126.com China 20027 58
Hangzhou Runyan Medical Technology Co., LTD 571-13989459766 18112526015 sales@runyanpharma.com China 496 58
Beijing Boorsen Biotechnology Co., Ltd 400-901-9800 18611424007 cis@bioss.com.cn China 9185 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 6206333 13167063860 anhua.mao@aladdin-e.com China 43293 58
Supplier Advantage
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai Hongye Biotechnology Co. Ltd 58
TargetMol Chemicals Inc. 58
Sichuan Changdexiangshun Co., Ltd. 58
TargetMol Chemicals Inc. 58
Suzhou Meishi Biotechnology Co., Ltd. 58
Hangzhou Runyan Medical Technology Co., LTD 58
Beijing Boorsen Biotechnology Co., Ltd 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58

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Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Nelivaptan pictures 2026-07-15 Nelivaptan
439687-69-1
 $71.00-220.00 99.46% 10g TargetMol Chemicals Inc.
Nelivaptan(SSR-149415) pictures 2025-08-21 Nelivaptan(SSR-149415)
439687-69-1
 1g 99.0%min. HPLC 10000 HangZhou RunYan Pharma Technology Co.,LTD.
  • Nelivaptan pictures
  • Nelivaptan
    439687-69-1
  • $71.00-220.00
  • 99.46%
  • TargetMol Chemicals Inc.

(2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide Spectrum

(2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE(439687-69-1)1HNMR

439687-69-1((2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide)Related Search:

(S)-(-)-N-ISOPROPYL-1-PHENYLETHYLAMINE HYDROCHLORIDE 2-(Diisopropylamino)ethanol hydrochloride (R)-(+)-1-Benzyl-3-pyrrolidinol (R)-1-(3-Chlorophenyl)ethanamine (R)-N-(2-Propyl)-1-phenylethylamine hydrochloride
(R)-1-(2-Methoxyphenyl)ethylamine (S)-1-(3-Chlorophenyl)ethylamine (S)-1-(2-Methoxyphenyl)ethylamine (2S,4R)-1-[(R)-5-CHLORO-1-(2,4-DIMETHOXY-BENZENESULFONYL)-3-(2-METHOXY-PHENYL)-2-OXO-2,3-DIHYDRO-1H-INDOL-3-YL]-4-HYDROXY-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE 2-Phenyl-2-pyrrolidinylethylamine
1-(3-Chlorophenyl)-N1,N1-dimethyl-1,2-ethanediamine (1-Isopropyl-2-pyrrolidinyl)methylamine 2-(3-chlorophenyl)-2-pyrrolidin-1-ylethanamine H-PHG-NH2 HCL 1-(alpha-Methylbenzyl)pyrrolidine hydrochloride
(1-Isopropyl-2-pyrrolidinyl)-N-methylmethanamine 2-phenyl-2-pyrrolidin-1-ylacetamide 2-(Diethylamino)-2-phenylacetamide hydrochloride

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2-PYRROLIDINECARBOXAMIDE, 1-[(3R)-5-CHLORO-1-[(2,4-DIMETHOXYPHENYL)SULFONYL]-2,3-DIHYDRO-3-(2-METHOXYPHENYL)-2-OXO-1H-INDOL-3-YL]-4-HYDROXY-N,N-DIMETHYL-, (2S,4R)- Nelivaptan(SSR-149,415) (2S,4R)-1-[(3R)-5-chloro-1-(2,4-dimethoxyphenyl)sulfonyl-3-(2-methoxyphenyl)-2-oxoindol-3-yl]-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide SSR 149415 (2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide SSR 149415 - Nelivaptan (2S,4R)-1-((R)-5-Chloro-1-((2,4-dimethoxyphenyl)sulfonyl)-3-(2-methoxyphenyl)-2-oxoindolin-3-yl)-4-hydroxy-N,N-dimethylpyrrolidine-2-carboxamide NB-415 Nelivaptan (2S,4R)-1-[(R)-5-Chloro-1-(2,4-dimethoxy-benzenesulfonyl)-3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl]-4-hydroxy-pyrrolidine-2-carboxylic acid dimethylamide 439687-69-1 C30H32ClN3O8S