(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid
![(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid Structure](CAS/GIF/844639-57-2.gif)
- CAS No.
- 844639-57-2
- Chemical Name:
- (+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid
- Synonyms
- TM30089;CS-1157;TM30089 Racemate;CAY10471 Racemate;TM 30089;TM-30089;TM30089 (CAY10471);CAY10471 Racemate, 10 mM in DMSO;9H-Carbazole-9-acetic acid, 3-[[(4-fluorophenyl)sulfonyl]MethylaMino]-1,2,3,4-tetrahydro-;(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid;CAY 10471,CAY10471,TM30089,Inhibitor,CAY-10471,TM 30089,TM-30089,CAY10471 Racemate,inhibit,Prostaglandin Receptor,CAY-10471 Racemate
- CBNumber:
- CB02448675
- Molecular Formula:
- C21H21FN2O4S
- Molecular Weight:
- 416.47
- MDL Number:
- MFCD08062186
- MOL File:
- 844639-57-2.mol
- MSDS File:
- SDS
(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid Properties
| Melting point | 165-173℃ (dichloromethane ) |
|---|---|
| Boiling point | 639.1±65.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 150 mg/mL (360.17 mM) |
| form | Solid |
| pka | 4.33±0.10(Predicted) |
| color | Off-white to light yellow |
| InChI | 1S/C21H21FN2O4S/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26) |
| InChIKey | CANCTKXGRVNXFP-UHFFFAOYSA-N |
| SMILES | Fc1ccc(cc1)[S](=O)(=O)N(C2CCc3[n](c4c(c3C2)cccc4)CC(=O)O)C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H317-H319-H410 |
| Precautionary statements | P273-P280-P302+P352-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 |
(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2743 | TM30089 ≥98% (HPLC) | 844639-57-2 | 5MG | $98.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2743 | TM30089 ≥98% (HPLC) | 844639-57-2 | 25MG | $394.4 | 2026-04-30 | Buy |
| ChemScene | CS-0007735 | CAY10471 Racemate 99.00% | 844639-57-2 | 5mg | $97 | 2026-06-04 | Buy |
| ChemScene | CS-0007735 | CAY10471 Racemate 99.00% | 844639-57-2 | 10mg | $152 | 2026-06-04 | Buy |
| ChemScene | CS-0007735 | CAY10471 Racemate 99.00% | 844639-57-2 | 25mg | $314 | 2026-06-04 | Buy |
(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid Chemical Properties, Uses, Production
Uses
CAY10471 Racemate (TM30089 Racemate) is a potent and highly selective prostaglandin D2 receptor CRTH2 antagonist, with a Ki of 0.6 nM for hCRTH2, selective over human thromboxane A2 receptor TP (Ki, >10000 nM) or PGD2 receptor DP (Ki, 1200 nM). CAY10471 Racemate also has effect on mouse and rat orthologs of CRTH2[1].
Biological Activity
TM30089 is a ramatroban analog and an orally active, high-affinity, potent and selective prostaglandin D2 receptor 2 (DP2; CRTH2) antagonist (Ki = 0.6 nM/hDP2 against 1.2 nM PGD2; Ki = 1.2 μM/hDP1 against 0.5 nM PGD2, >10 μM/hTP against 5 nM SQ29548) th at blocks PGD2-induced responses in hDP2 transfectants (IP1/βarr IC50 = 1.2/3.0 nM) and exhibits in vivo efficacy in a murine model of renal tubulointerstitial fibrosis (20 mg/kg b.i.d. p.o., starting 4 days before or 3 days after unilateral ureteral obstruction/UUO).
IC 50
CRTH2: 0.6 nM (Ki)
References
[1] Ulven T, et al. Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist. J Med Chem. 2005 Feb 24;48(4):897-900. DOI:10.1021/jm049036i
(+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Shanghai Synchem Pharma Co., ltd | 21-619849051-1 18521059765 | synchempharma@aliyun.com | China | 4988 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| Medi-tech Bioscientific Co., Ltd. | 0519-83246372 13585352506 | China | 1838 | 58 | |
| Shanghai Biopharmaleader Co., Ltd. | +86 18721201413 | sales@biopharmaleader.com | China | 1711 | 58 |
| Angel Pharmatech, Ltd. | 17317130613 | 3358272972@qq.com | China | 3307 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| Shanghai Fuyi Biological Technology Co., Ltd. | 18096642264;18096409024 | sales@foreversyn.com | China | 492 | 58 |
View Latest Price from (+)-3-[[(4-Fluorophenyl)sulfonyl]methylamino]-1,2,3,4-tetrahydro-9H-carbazole-9-acetic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | CAY10471 Racemate
844639-57-2
|
$43.00-143.00 | 99.08% | 10g | TargetMol Chemicals Inc. |
-
- CAY10471 Racemate
844639-57-2
- $43.00-143.00
- 99.08%
- TargetMol Chemicals Inc.
