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5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine

5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine structure

CAS No.: 134218-81-8

Chemical Name:: 5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine

Synonyms: TBDMS-I-dU;5′-O-TBSIODO DU;5'-O-TBS-5-iodo dU;5'-O-TBDMS-5-I-2'-dU;5'-TBDMS-5-Iodo-2'-dU;5'-O-TBDMS-5-iodo-2'-deoxyuridine;2'-Deoxy-5'-O-TBDMS-5-Iodo-Uridine;5'-O-TBDMSoxy-5-iodo-2'-deoxyuridine;2'-Deoxy-5'-O-TBDMS-5-Iodo-Uridine, >98%;5’-O-t-Butyldimethylsilyl2’-deoxy-5-iodo-uridine

CBNumber:: CB02449511

Molecular Formula:: C15H25IN2O5Si

Molecular Weight:: 468.36

MDL Number:: MFCD09264240

MOL File:: 134218-81-8.mol

MSDS File:: SDS

Last updated:2026-09-12 18:48:00

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5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine Properties

Melting point	218-219 °C
Density	1.52±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	7.94±0.10(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319
Precautionary statements	P261-P305+P351+P338

5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	NB08643	5'-O-tert-Butyldimethylsilyl-2'-deoxy-5-iodouridine	134218-81-8	1000mg	$170	2026-06-04	Buy
Biosynth	NB08643	5'-O-tert-Butyldimethylsilyl-2'-deoxy-5-iodouridine	134218-81-8	2000mg	$260	2026-06-04	Buy
Biosynth	NB08643	5'-O-tert-Butyldimethylsilyl-2'-deoxy-5-iodouridine	134218-81-8	5000mg	$550	2026-06-04	Buy
Biosynth	NB08643	5'-O-tert-Butyldimethylsilyl-2'-deoxy-5-iodouridine	134218-81-8	10000mg	$800	2026-06-04	Buy
Matrix Scientific	291919	1-((2R,4S,5R)-5-(((tert-Butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione	134218-81-8	100.00mg	$26	2026-05-19	Buy

Product number	Packaging	Price	Buy
NB08643	1000mg	$170	Buy
NB08643	2000mg	$260	Buy
NB08643	5000mg	$550	Buy
NB08643	10000mg	$800	Buy
291919	100.00mg	$26	Buy

5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine Chemical Properties, Uses, Production

Synthesis

54-42-2

18162-48-6

5'-O-(TERT-BUTYLDIMETHYLSILYL)-5-IODO-2'-DEOXYURIDINE

134218-81-8

GENERAL STEPS: To an anhydrous N,N-dimethylformamide (DMF, 70 mL) solution of 5-iodo-2'-deoxyuridine (5.0 g, 14 mmol) was added imidazole (1.09 g, 16 mmol), followed by tert-butyldimethylsilyl chloride (TBDMSCl, 2.41 g, 16 mmol) at 0 °C. The reaction mixture was placed in an ice bath and stirred overnight. Upon completion of the reaction, it was quenched with saturated aqueous NaHCO3 and washed with aqueous NaCl followed by extraction with ethyl acetate (EtOAc). The organic layer was dried over anhydrous magnesium sulfate (MgSO4) and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (eluent: EtOAc/petroleum ether, 3:7, v/v) to afford the target product 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione (5.9 g, 90% yield) as colorless solid. 1H NMR (d6-DMSO) δ: 0.00 (s, 3H, CH3), 0.79 (s, 9H, tBu), 1.88-1.97 (m, 1H, H-2'), 2.00-2.05 (m, 1H, H-2'), 3.59-3.71 (m, 2H, H-5'), 3.75 (br s, 1H, H-4'), 4.06 (br s, 1H, H-3'), 5.18 (d, J = 4.0 Hz, 1H, OH), 5.98 (t, J = 5.9 Hz, 1H, H-1'), 7.89 (s, 1H, H-6), 11.62 (s, 1H, NH). MS (negative electrospray): calculated value C15H25IN2O5Si [M-H]- 468.06, measured value 467.

References

[1] Patent: EP2607369, 2015, B1. Location in patent: Paragraph 0176
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 7, p. 1840 - 1846
[3] Patent: WO2017/58953, 2017, A1. Location in patent: Paragraph 0905; 0906
[4] European Journal of Medicinal Chemistry, 2015, vol. 101, p. 668 - 680
[5] European Journal of Medicinal Chemistry, 2016, vol. 120, p. 304 - 312

5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine Preparation Products And Raw materials

Raw materials

Idoxuridine tert-Butyldimethylsilyl chloride N,N-Dimethylformamide Imidazole

Preparation Products

5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine Suppliers

Global Suppliers ( 52)

Supplier	Tel	Email	Country	ProdList	Advantage
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.	0371-85513397	info@granlen.com	China	497	55
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
Wuhu Nuowei Chemical Technology Co., Ltd	0553-8233716 18055326116	sales@nuowei-chem.com	China	742	55
NanJing Xienuo bio Co.,Ltd.	025-84112752 13805181430	154301870@qq.com	China	999	55
Jinan elephant international trading co., LTD		13006575422@163.com	China	6347	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Wuxi AppTec	022-59987777 13552403979	jia_guoqiang@wuxiapptec.com	China	22344	58
Bejing Famous Pharmaceutical Technology Co., Ltd.	010-80339217; 13331045123	2559355526@qq.com	China	14180	58
3A Chemicals	400-668-9898	service@3achem.com	China	20535	58

Supplier	Advantage
T&W GROUP	58
Zhengzhou GranLen pharmaceutical Technology Co., Ltd.	55
Cool Pharm, Ltd	58
Wuhu Nuowei Chemical Technology Co., Ltd	55
NanJing Xienuo bio Co.,Ltd.	55
Jinan elephant international trading co., LTD	58
Amadis Chemical Company Limited	58
Wuxi AppTec	58
Bejing Famous Pharmaceutical Technology Co., Ltd.	58
3A Chemicals	58

View Latest Price from 5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-18	5'-TBDMS-5-Iodo-2'-dU 134218-81-8		100g	97%min	100kgs	WUHAN FORTUNA CHEMICAL CO., LTD
	2026-04-20	5'-O-t-Butyldimethylsilyl 2'-deoxy-5-iodo-uridine 134218-81-8				10g	TargetMol Chemicals Inc.

5'-TBDMS-5-Iodo-2'-dU
134218-81-8
97%min
WUHAN FORTUNA CHEMICAL CO., LTD

5'-O-t-Butyldimethylsilyl 2'-deoxy-5-iodo-uridine
134218-81-8
TargetMol Chemicals Inc.

134218-81-8 (5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine) Related Search:

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4'-alpha-C-Allyl-2',3'-bis(O-t-butyldimethylsilyl)uridine

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5'-O-tert-Butyldimethylsilyl-2'-deoxy-5-iodouridine 5'-O-t-ButyldiMethylsilyl 2'-deoxy-5-iodo-uridine 1-[(2R,4S,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-hydroxyoxolan-2-yl]-5-iodopyrimidine-2,4-dione 2'-Deoxy-5'-O-TBDMS-5-Iodo-Uridine 5'-O-TBDMS-5-iodo-2'-deoxyuridine 1-((2R,4S,5R)-5-(((tert-Butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodopyrimidine-2,4(1H,3H)-dione 5′-O-TBSIODO DU 5'-O-TBS-5-iodo dU 2'-Deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-iodouridine 5'-TBDMS-5-Iodo-2'-dU 2'-Deoxy-5'-O-TBDMS-5-Iodo-Uridine, >98% Uridine, 2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-iodo- 5'-O-TBDMSoxy-5-iodo-2'-deoxyuridine 5’-O-t-Butyldimethylsilyl2’-deoxy-5-iodo-uridine 5'-O-TBDMS-5-I-2'-dU TBDMS-I-dU 1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-iodo-4l5-pyrimidine-2,4(1H)-dione 5'-O-(tert-Butyldimethylsilyl)-5-iodo-2'-deoxyuridine 134218-81-8 C15H25IN2O5Si