N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
- CAS No.
- 189060-98-8
- Chemical Name:
- N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE
- Synonyms
- N B2904;Ngb-2904;Ngb 2904;NGB2904 HCl;NGB 2904 HYDROCHLORIDE;NGB 2904, 10 mM in DMSO;N-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyl)-3-fluorenylcarboxamide;N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide;N-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl]-9H-fluorene-2-carboxamide;9H-Fluorene-2-carboxamide, N-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyl)-
- CBNumber:
- CB02453431
- Molecular Formula:
- C28H29Cl2N3O
- Molecular Weight:
- 494.46
- MDL Number:
- MFCD09971107
- MOL File:
- 189060-98-8.mol
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Properties
Boiling point | 691.0±55.0 °C(Predicted) |
---|---|
Density | 1.264±0.06 g/cm3(Predicted) |
storage temp. | Desiccate at +4°C |
solubility | DMSO: 25 mM,Ethanol: 5 mM |
pka | 14.70±0.20(Predicted) |
form | Solid |
color | White to off-white |
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 2635 | NGB2904 ≥98%(HPLC) | 189060-98-8 | 10 | $217 | 2021-12-16 | Buy |
Tocris | 2635 | NGB2904 ≥98%(HPLC) | 189060-98-8 | 50 | $872 | 2021-12-16 | Buy |
TRC | N393505 | NGB2904 | 189060-98-8 | 10mg | $160 | 2021-12-16 | Buy |
Usbiological | 255979 | NGB 2904 | 189060-98-8 | 10mg | $466 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | HCH0360490 | N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE 95.00% | 189060-98-8 | 5MG | $501.96 | 2021-12-16 | Buy |
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Chemical Properties,Uses,Production
Uses
NGB 2904 is a highly-selective D3DR antagonist.
Biological Activity
Potent and selective dopamine D 3 receptor antagonist (K i values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D 3 , D 2 , 5-HT 2 , α 1 , D 4 , D 1 and D 5 receptors respectively). Potently antagonizes quinpirole-stimulated mitogenesis (IC 50 = 6.8 nM). Attenuates cocaine's rewarding effects and inhibits relapse to drug-seeking behavior.
in vivo
NGB 2904 (26 μg/kg; a single s.c.) enhances amphetamine (26 mg/kg)-stimulated locomotion in wild-type mice[3].
NGB 2904 (0.026 μg-1 mg/kg; a single s.c. or once daily for 7 d) stimulates spontaneous locomotion in wild-type mice[3].
IC 50
D3 Receptor: 1.4 nM (Ki)
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-[4-[4-(2,3-DICHLOROPHENYL)-1-PIPERAZINYL]BUTYL]-9H-FLUORENE-2-CARBOXAMIDE HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32432 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6772 | 55 |
ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
Shanghai Chaolan Chemical Technology Center | 021-QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 9848 | 58 |
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Shanghai Dongyang Biotechnology Co., Ltd. | 0512-0512-13601744364 13601744364 | chemsharker@126.com | China | 998 | 58 |
ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4995 | 58 |