5-Amino-4-bromopyrimidine
- CAS No.
- 849353-34-0
- Chemical Name:
- 5-Amino-4-bromopyrimidine
- Synonyms
- 5-Amino-4-bromopyrimidine;5-Pyrimidinamine, 4-bromo-;4-bromopyrimidin-5-ylamine;5-AMINO-4-BROMOPYRIMIDINE ISO 9001：2015 REACH
- CBNumber:
- CB02453754
- Molecular Formula:
- C4H4BrN3
- Molecular Weight:
- 174
- MDL Number:
- MFCD09999203
- MOL File:
- 849353-34-0.mol
- MSDS File:
- SDS
| Boiling point | 282.2±20.0 °C(Predicted) |
|---|---|
| Density | 1.844±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | 1.10±0.16(Predicted) |
| Appearance | Light yellow to yellow Solid |
| InChI | InChI=1S/C4H4BrN3/c5-4-3(6)1-7-2-8-4/h1-2H,6H2 |
| InChIKey | NXYSMLJPDPVHOE-UHFFFAOYSA-N |
| SMILES | C1=NC=C(N)C(Br)=N1 |
5-Amino-4-bromopyrimidine price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR927026 | 5-Amino-4-bromopyrimidine 95% | 849353-34-0 | 250mg | $88 | 2026-06-04 | Buy |
| Apolloscientific | OR927026 | 5-Amino-4-bromopyrimidine 95% | 849353-34-0 | 1g | $181 | 2026-06-04 | Buy |
| Activate Scientific | AS30879 | 5-Amino-4-bromopyrimidine 98% | 849353-34-0 | 1g | $224 | 2026-06-04 | Buy |
| Activate Scientific | AS30879 | 5-Amino-4-bromopyrimidine 98% | 849353-34-0 | 5g | $726 | 2026-06-04 | Buy |
| aablocks | AA0052Y3 | 4-Bromo-5-pyrimidinamine 95% | 849353-34-0 | 250mg | $62 | 2026-05-28 | Buy |
5-Amino-4-bromopyrimidine Chemical Properties, Uses, Production
Uses
5-Amino-4-bromopyrimidine is a useful research chemical compound.
Synthesis
591-55-9
849353-34-0
General procedure for the synthesis of 5-amino-4-bromopyrimidine from 5-aminopyrimidine: 1. 5-amino-4,6-dichloropyridine (5.0 g, 30.5 mmol) was dissolved in 250 mL of diethyl ether, to which was added sodium hydroxide solution (20.0 g, 0.50 mol, dissolved in 60 mL of water) and palladium catalyst (10% carbon-loaded palladium, 400 mg). 2. The mixture was placed in a Parr shaker and the reaction was shaken at room temperature under 50 psi hydrogen pressure for 20 hours. 3. Upon completion of the reaction, the mixture was filtered through a CELITES filter aid to separate the organic and aqueous phases. The aqueous phase was extracted with three 100mL portions of ethyl acetate. 4. The organic layers were combined, dried with magnesium sulfate, filtered and concentrated in vacuum. The crude product was crystallized from ethyl acetate to give pyrimidin-5-ylamine as a white crystalline solid (2.8 g, 95% yield). 5. The bromination of pyrimidin-5-ylamine was carried out under the same conditions as for the preparation of 4-amino-3-bromo-2,6-dimethylpyridine. The crude product (300 mg, 35% yield) obtained was of sufficient purity to be used without further purification. Alternative synthetic method: 1. 4,6-Dichloro-5-aminopyrimidine (21 g, 128 mmol) was dissolved in 250 mL of methanol and ammonium formate (45 g, 714 mmol) and palladium catalyst (10% carbon-loaded palladium, 1 g, 0.943 mmol) were added sequentially at 0°C. 2. The mixture was stirred at room temperature overnight and after completion of the reaction was filtered through a CELITEO filter aid. 3. The filtrate was concentrated to give a yellow solid to which 100 mL of water and 250 mL of ethyl acetate were added. The organic phase was separated and the aqueous phase was extracted with eight 250mL of ethyl acetate. 4. The organic layers were combined, dried with magnesium sulfate, filtered and concentrated in vacuum to give off-white crystals (8.1 g, 67%). 5. 5-Aminopyridine (3.0 g, 31.5 mmol) was dissolved in 150 mL of dichloromethane and 30 mL of methanol and cooled to 0°C. Benzyltrimethylammonium tribromide (13.5 g, 34.7 mmol) was added in batches over 10 min. 6. Stirring was continued at 0 °C for 15 min and then at room temperature for 90 min. The reaction mixture was adjusted to pH 8 with aqueous sodium bicarbonate. 7. The organic layer was separated and the aqueous layer was extracted with three 30 mL of ethyl acetate. The organic extracts were combined, dried with sodium sulfate, filtered and concentrated in vacuum to give an off-white solid (2.8 g, 51%) of sufficient purity to be used without further purification.
References
[1] Patent: WO2005/30213, 2005, A1. Location in patent: Page/Page column 177
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 4, p. 1583 - 1598
[3] Patent: WO2013/117649, 2013, A1. Location in patent: Paragraph 0053
5-Amino-4-bromopyrimidine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7880 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Hekang Biotechnology Co., Ltd. | 17721021104 18939837085 | 2880152141@qq.com | China | 1840 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Worldyang Chemical Co.,Ltd. | 021-56795766 | sales@worldyachem.com | China | 9475 | 58 |
| Hangzhou Milestone Pharmtech Co., Ltd. | 0571-82896630 18969958410 | sales_hz@milestonepharmtech.com | China | 4909 | 55 |
View Latest Price from 5-Amino-4-bromopyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-AMINO-4-BROMOPYRIMIDINE
849353-34-0
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-26 | 5-AMINO-4-BROMOPYRIMIDINE
849353-34-0
|
1KG | 95%-99% | 1kg; 100kg; 1000kg | Career Henan Chemical Co |
-
- 5-AMINO-4-BROMOPYRIMIDINE
849353-34-0
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-AMINO-4-BROMOPYRIMIDINE
849353-34-0
- $0.10
- 95%-99%
- Career Henan Chemical Co
