CAY10580
- CAS No.
- 64054-40-6
- Chemical Name:
- CAY10580
- Synonyms
- CAY10580;CAY10580 Exclusive;CBWGHEDGUILASE-UHFFFAOYSA-N;2-(3-HYDROXYOCTYL)-5-OXO-1-PYRROLIDINEHEPTANOIC ACID;1-Pyrrolidineheptanoic acid, 2-(3-hydroxyoctyl)-5-oxo-
- CBNumber:
- CB02467917
- Molecular Formula:
- C19H35NO4
- Molecular Weight:
- 341.49
- MDL Number:
- MFCD11976917
- MOL File:
- 64054-40-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
CAY10580 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16835 | CAY10580 ≥96% | 64054-40-6 | 500μg | $79 | 2026-04-30 | Buy |
| Cayman Chemical | 16835 | CAY10580 ≥96% | 64054-40-6 | 1mg | $147 | 2026-04-30 | Buy |
| Cayman Chemical | 16835 | CAY10580 ≥96% | 64054-40-6 | 5mg | $610 | 2026-04-30 | Buy |
| Cayman Chemical | 16835 | CAY10580 ≥96% | 64054-40-6 | 10mg | $1065 | 2026-04-30 | Buy |
| ChemScene | CS-0110313 | CAY10580 97.4% | 64054-40-6 | 1mg(14.64mM*200??LinEthanol) | $433 | 2026-06-04 | Buy |
CAY10580 Chemical Properties, Uses, Production
Uses
Prostaglandin E2 (PGE2) activates four E prostanoid (EP) receptors, EP1-4. EP4 is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10580 is an 8-aza-9-oxo-15-hydroxy saturated analog of PGE2. It selectively binds the EP4 receptor (Ki = 35 nM) relative to the EP1, EP2, and EP3 receptors (Ki = 3,000, 2,000, and >3,000 nM, respectively). CAY10580 stimulates cAMP formation in excised mouse ovaries.[Cayman Chemical]
Uses
2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is an analog of PGE2.
Definition
ChEBI: 2-(3-hydroxyoctyl)-5-oxo-1-pyrrolidineheptanoic acid is a pyrrolidin-2-one substituted by 6-carboxyhexyl and 3-hydroxyoctyl groups at positions 1 and 2, respectively. It is a potent prostaglandin EP4 receptor agonist (Ki=35 nM). It has a role as a prostaglandin receptor agonist. It is a member of pyrrolidin-2-ones, a hydroxy monocarboxylic acid and a secondary alcohol.
in vivo
CAY10580 (200 μg/kg body weight; i.p; daily for three weeks) effectively prevents diet-induced hypercholesterolemia, enhances endogenous bile acid synthesis and their fecal excretion[3].
| Animal Model: | Six-week old male EP4+/+ mice (Treating high fat diet-challenged mice)[3] |
| Dosage: | 200 μg/kg body weight |
| Administration: | Intraperitoneal injection; daily for remaining three weeks |
| Result: | High fat diet fed mice exhibited lower total cholesterol levels compared to the vehicle group by 28.5%. Total cholesterol levels decreased from 137.4 to 98.2 mg/dl, restoring plasma cholesterol back to near-normal values. |
IC 50
EP4: 35 nM (Ki); EP2: 3000 nM (Ki); EP3: 2000 nM (Ki); EP1: >3000 nM (Ki)
CAY10580 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Tachizaki Biomedical Research Center | 18014399201 | sales@chemlab-tachizaki.com | China | 2934 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | 6206333 13167063860 | anhua.mao@aladdin-e.com | China | 43486 | 58 |
