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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Structure
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate structure
CAS No.
1181816-12-5
Chemical Name:
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
Synonyms
tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate;2-Boc-6-oxo-2-azaspiro[3....;6-oxo-2-azaspiro[3.3]hept...;2-Boc-6-oxo-2-azaspiro[3.3]heptane;6-oxo-2-azaspiro[3.3]heptane-2-carboxyL;tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca;ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate;Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate;tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate;tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
CBNumber:
CB02470890
Molecular Formula:
C11H17NO3
Molecular Weight:
211.26
MDL Number:
MFCD15071430
MOL File:
1181816-12-5.mol
MSDS File:
SDS
Last updated:2026-05-27 17:24:41
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tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Properties

Melting point 114.5-116 °C
Boiling point 314.7±42.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka -0.93±0.20(Predicted)
form solid
color Pale yellow
InChI InChI=1S/C11H17NO3/c1-10(2,3)15-9(14)12-6-11(7-12)4-8(13)5-11/h4-7H2,1-3H3
InChIKey HQHRAGXKFOTSQE-UHFFFAOYSA-N
SMILES C1C2(CC(=O)C2)CN1C(OC(C)(C)C)=O
CAS DataBase Reference 1181816-12-5

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302+H312+H332-H315
Precautionary statements  P280-P301+P312-P304+P340
HS Code  2933998090

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate price More Price(74)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D6207 tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate min. 98.0 % 1181816-12-5 1G $49 2026-04-30 Buy
TCI Chemical D6207 tert-Butyl 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylate min. 98.0 % 1181816-12-5 5G $139 2026-04-30 Buy
Biosynth GXB81612 tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5 25g $454.25 2026-06-04 Buy
Biosynth GXB81612 tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5 50g $649 2026-06-04 Buy
Biosynth GXB81612 tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate 1181816-12-5 100g $844 2026-06-04 Buy
Product number Packaging Price Buy
D6207 1G $49 Buy
D6207 5G $139 Buy
GXB81612 25g $454.25 Buy
GXB81612 50g $649 Buy
GXB81612 100g $844 Buy

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Chemical Properties, Uses, Production

Uses

tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate is a reagent used for the preparation of γ-butyrolactone derivative via Baeyer-Villiger monooxygenase (BVMO)-catalyzed oxidation.

Synthesis

A solution of crude tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate (1.00 g,4.69mmol, 1.00 equiv) in dichloromethane(20 mL) was treated with Dess-Martin periodinane(2.10g,4.95 mmol, 1.06 equiv) in two batches a few min apart at 0 °C. After 10 min, the ice bath wasremoved, and the reaction was monitored by TLC (50% ethyl acetate, PMA stain). After 30 min.the reaction was diluted with ethyl acetate and washed twice with satd sodium bicarbonate. Theorganic layer was dried over sodium sulfate, filtered, and concentrated. The crude product waspurified by flash chromatography (80g silica gel, 10 to 50% ethyl acetate/heptane; pure fractionswere identified by TLC with PMA stain; an unidentified impurity elutes slightly earlier than theproduct) to give tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate as a white solid (721 mg,73%). mp 114.5-116C. 

References

[1] Patent: CN106565706, 2017, A. Location in patent: Paragraph 0176; 0177; 0178
[2] Organic Letters, 2009, vol. 11, # 16, p. 3523 - 3525
[3] Patent: US2011/319381, 2011, A1. Location in patent: Page/Page column 15
[4] Patent: US2012/129830, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: WO2015/48507, 2015, A1. Location in patent: Paragraph 0219

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate synthesis

1239320-10-5
1181816-12-5
Synthesis of tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate from tert-butyl 5,5-dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Preparation Products And Raw materials

Raw materials

tert-butyl 5,5-dichloro-6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Ammonium chloride ZINC Methanol

Preparation Products

6-Amino-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester tert-butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Suppliers

Global Suppliers ( 210)
Supplier Tel Email Country ProdList Advantage
Aikon International Limited 025-66061636 19370895928 qqyang@aikonchem.com China 15810 58
Anhui Nature Pharmaceutical Co., Ltd. 19155667820 sales@nuoquanpharm.com China 131 58
Chunchuang (Wuhan) Technology Co., Ltd 15727060112 yutianchun2007@126.com China 9870 58
Nanjing Huarui Biopharmaceutical Technology Co., Ltd. 18014824111 1623163500@qq.com China 350 58
CE Pharm Co.,Ltd 15317222985 xin.yu@cepharm.cn China 160 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 45000 61
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Accela ChemBio Co.,Ltd. 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shanghai Feibo Chemical Technology Co., Ltd 021-58955608,2250286 15921236618 blinkzeng@gmail.com China 522 62
Supplier Advantage
Aikon International Limited 58
Anhui Nature Pharmaceutical Co., Ltd. 58
Chunchuang (Wuhan) Technology Co., Ltd 58
Nanjing Huarui Biopharmaceutical Technology Co., Ltd. 58
CE Pharm Co.,Ltd 58
Energy Chemical 61
Beijing Ouhe Technology Co., Ltd 60
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shanghai Feibo Chemical Technology Co., Ltd 62

View Latest Price from tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate pictures 2026-08-25 tert-Butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
 $2.00-6.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate pictures 2026-08-25 tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
 $100.00-1600.00 5g 99% 30 Zibo Hangyu Biotechnology Development Co., Ltd
tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate pictures 2025-12-24 tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate
1181816-12-5
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Spectrum

tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate(1181816-12-5)1HNMR

1181816-12-5 (tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate) Related Search:

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6-Oxo-2-aza-spiro[3.3]heptane-2-carboxylic acid tert-butyl ester 6-oxo-2-azaspiro[3.3]hept... 2-Boc-6-oxo-2-azaspiro[3.... 2-Boc-6-oxo-2-azaspiro[3.3]heptane tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-carboxylate 2-Azaspiro[3.4]octane-2-carboxylic acid, 6-oxo-, 1,1-dimethylethyl ester 6-Oxo-2-azaspiro[3.3]heptane-2-carboxylic acid dimethylethyl ester tert-Butyl 7-oxo-2-azaspiro[3.4]octane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.3]heptane-2-carboxylate tert-butyl 6-oxo-2-azaspiro[3.4]octane-2-ca 6-oxo-2-azaspiro[3.3]heptane-2-carboxyL ert-Butyl6-oxo-2-azaspiro[3.3]heptane-2-carboxylate Tert-butyl-6-oxo-2-azaspiro[3,3]heptane-2-carxylate 1181816-12-5 MFCD22421762 oldold