1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine
- CAS No.
- 614730-97-1
- Chemical Name:
- 1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine
- Synonyms
- tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate;1-Boc-4-fluoro-4-(hydroxy...;1-BOC-4-FLUORO-4 (HYDROXYMETHYL);1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine;tert-Butyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 97%;1,1-Dimethylethyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER
- CBNumber:
- CB5347225
- Molecular Formula:
- C11H20FNO3
- Molecular Weight:
- 233.28
- MDL Number:
- MFCD08062513
- MOL File:
- 614730-97-1.mol
- MSDS File:
- SDS
| Boiling point | 311.0±27.0 °C(Predicted) |
|---|---|
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| pka | 14.94±0.10(Predicted) |
| Appearance | Colorless to off-white Solid-Liquid Mixture |
| InChI | InChI=1S/C11H20FNO3/c1-10(2,3)16-9(15)13-6-4-11(12,8-14)5-7-13/h14H,4-8H2,1-3H3 |
| InChIKey | BWZOULIMVKCGII-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(F)(CO)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| HS Code | 2933399990 |
1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC430313 | tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 95% | 614730-97-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC430313 | tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 95% | 614730-97-1 | 5g | $58 | 2026-06-04 | Buy |
| Apolloscientific | PC430313 | tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 95% | 614730-97-1 | 25g | $285 | 2026-06-04 | Buy |
| Apolloscientific | PC430313 | tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 95% | 614730-97-1 | 100g | $1132 | 2026-06-04 | Buy |
| Matrix Scientific | 096940 | 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine | 614730-97-1 | 5.00g | $44 | 2026-05-18 | Buy |
1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine Chemical Properties, Uses, Production
Uses
tert-Butyl 4-Fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is used in preparation of heterocyclic compounds as BCL 2 inhibitors.
Synthesis
![1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER](/CAS/GIF/147804-30-6.gif)
147804-30-6
614730-97-1
General procedure for the synthesis of 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine from 1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester: Commercially available epoxide (2 g, 9.38 mmol) was dissolved in 10 mL of dichloromethane, and added slowly and dropwise to a pre-cooled to -10°C 0.6 mL solution of HF pyridinium fluoride (70%) in a 10 mL dichloromethane to a mixture of 0.6 mL HF pyridinium fluoride (70%) and 10 mL methylene chloride. The reaction mixture was kept at -10°C. After the dropwise addition was completed, the reaction system was warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and subsequently washed with saturated aqueous sodium carbonate solution. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent to give the crude product. Purification by silica gel column chromatography with ethyl acetate/heptane (20% to 50%) as eluent afforded 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine as a pale yellow oil (1.44 g, 66% yield).1H-NMR (400 MHz, CDCl3) data: δ=1.44 (s, 9H), 1.47-1.63 (m, 2H). 1.85 (m, 2H), 3.08 (m, 2H), 3.56 (s, 1H), 3.61 (s, 1H), 3.92 (brs, 2H). ms ESI: m/z=233.98 (M+).
References
[1] Patent: US2011/256064, 2011, A1. Location in patent: Page/Page column 19; 20
[2] Patent: EP2377860, 2011, A1. Location in patent: Page/Page column 26
[3] Patent: EP1505067, 2005, A1. Location in patent: Page/Page column 368; 369
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 13, p. 3692 - 3695
[5] Patent: WO2004/5255, 2004, A1. Location in patent: Page 26-27
1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai AQBioPharma Co., Ltd. | 13661411401 | yinglv.que@aqbiopharma.com.cn | China | 2976 | 58 |
| Shanghai AQ BioPharma Co., Ltd. | 13512160998; 13512160998 | sales@aqbiopharma.com.cn | China | 3007 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai AmasPharm Co., Ltd. | 021-54540637 18621091017 | sales@amaspharm.com | China | 787 | 62 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
View Latest Price from 1-Boc-4-fluoro-4-(hydroxymethyl)-piperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-08-27 | 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
614730-97-1
|
$7.00 | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
614730-97-1
- $7.00
- 99%
- Career Henan Chemical Co
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