3-Chloro-4-trifluoromethylphenol
- CAS No.
- 37900-81-5
- Chemical Name:
- 3-Chloro-4-trifluoromethylphenol
- Synonyms
- 3-Chloro-4-trifluoromethylphenol;Phenol, 3-chloro-4-(trifluoromethyl)-
- CBNumber:
- CB02491484
- Molecular Formula:
- C7H4ClF3O
- Molecular Weight:
- 196.55
- MDL Number:
- MFCD11849933
- MOL File:
- 37900-81-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319 |
| Precautionary statements | P260-P280-P301+P310 |
| HS Code | 2908990000 |
3-Chloro-4-trifluoromethylphenol price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC500172 | 3-Chloro-4-(trifluoromethyl)phenol 98% | 37900-81-5 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC500172 | 3-Chloro-4-(trifluoromethyl)phenol 98% | 37900-81-5 | 1g | $54 | 2026-06-04 | Buy |
| Apolloscientific | PC500172 | 3-Chloro-4-(trifluoromethyl)phenol 98% | 37900-81-5 | 5g | $177 | 2026-06-04 | Buy |
| Activate Scientific | AS44099 | 3-Chloro-4-trifluoromethylphenol 98% | 37900-81-5 | 1g | $74 | 2026-06-04 | Buy |
| Activate Scientific | AS44099 | 3-Chloro-4-trifluoromethylphenol 98% | 37900-81-5 | 5g | $215 | 2026-06-04 | Buy |
3-Chloro-4-trifluoromethylphenol Chemical Properties, Uses, Production
Synthesis
94444-58-3
37900-81-5
The general procedure for the synthesis of 3-chloro-4-trifluoromethylphenol from 2-chloro-4-fluorobenzotrifluoride was as follows: to a stirred solution of 2-chloro-4-fluorobenzotrifluoride (500 mg, 2.52 mmol) in anhydrous N,N-dimethylformamide (10 mL) was added 2-(trimethylmethylsilyl)ethanol (0.40 mL, 2.77 mmol), and the reaction mixture was cooled to 0 °C. Subsequently, sodium hydride (302 mg, 60% w/w oil dispersion, 7.55 mmol) was added in batches. after 5 min, the reaction mixture formed a thick white suspension. The reaction mixture was slowly warmed to room temperature and stirring was continued for 16 hr. Upon completion of the reaction, the reaction was quenched with ice water (50 mL) and washed with ether (50 mL). The aqueous phase was acidified with 2 M aqueous hydrochloric acid and subsequently extracted with ether (2 x 50 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated in vacuum for 16 h to give 3-chloro-4-trifluoromethylphenol as a yellow oil (356 mg, 72% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.75 (dd, 1H), 6.95 (d, 1H), 7.51 (d, 1H).LCMS analysis showed a retention time of Rt = 1.23 min and a mass spectrum m/z 195 [MH]-.
References
[1] Patent: WO2012/7868, 2012, A2. Location in patent: Page/Page column 73-74
[2] Patent: US2012/10207, 2012, A1
3-Chloro-4-trifluoromethylphenol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 | |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Beijing Hechemist Technology CO.,LTD | 18511709189; | sales@hechemist.com | China | 2835 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
