DL-Methionine methylsulfonium chloride
- CAS No.
- 3493-12-7
- Chemical Name:
- DL-Methionine methylsulfonium chloride
- Synonyms
- VITAMIN U;CITRIN;VITAMIN U CHLORIDE;222-484-4;(3-Amino-3-carboxypropyl)dimethyl sulfonium chloride, Methyl-methionine sulphonium chloride, MMS, Vitamin U;Vitamine U;methylsulfonium;Vitaminuchloride,99%;VitaMin U Chloride(I);VitaMin U Chloride(Cl)
- CBNumber:
- CB0249997
- Molecular Formula:
- C6H14NO2S.Cl
- Molecular Weight:
- 199.7
- MDL Number:
- MFCD00031700
- MOL File:
- 3493-12-7.mol
- MSDS File:
- SDS
| Melting point | 139-140 °C (dec.) |
|---|---|
| FEMA | 3445 | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE |
| FLAVIS Number | 17.015 | DL-Methylmethioninesulphonium chloride |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: soluble100mg/mL, clear, colorless |
| form | Solid |
| color | White to Off-White |
| PH | 4.0-5.5 |
| biological source | synthetic |
| Water Solubility | Water: 250 mg/mL (1251.88 mM) |
| JECFA Number | 1427 |
| Merck | 14,6098 |
| BRN | 4163617 |
| Stability | Hygroscopic |
| InChI | 1S/C6H13NO2S.ClH/c1-10(2)4-3-5(7)6(8)9;/h5H,3-4,7H2,1-2H3;1H |
| InChIKey | MYGVPKMVGSXPCQ-UHFFFAOYSA-N |
| SMILES | [Cl-].C[S+](C)CCC(N)C(O)=O |
| CAS DataBase Reference | 3493-12-7(CAS DataBase Reference) |
| Substances Added to Food (formerly EAFUS) | DL-(3-AMINO-3-CARBOXYPROPYL)DIMETHYLSULFONIUM CHLORIDE |
| FDA UNII | 5Q59I6H55O |
| EPA Substance Registry System | Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, chloride (3493-12-7) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| TSCA | TSCA listed |
| HS Code | 29309090 |
| Storage Class | 11 - Combustible Solids |
DL-Methionine methylsulfonium chloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M0644 | DL-Methionine Methylsulfonium Chloride >99.0%(T) | 3493-12-7 | 25g | $54 | 2026-04-30 | Buy |
| TCI Chemical | M0644 | DL-Methionine Methylsulfonium Chloride >99.0%(T) | 3493-12-7 | 500g | $381 | 2026-04-30 | Buy |
| Usbiological | 283671 | DL-Methionine methylsulfonium chloride | 3493-12-7 | 25g | $333 | 2026-06-03 | Buy |
| Usbiological | 283671 | DL-Methionine methylsulfonium chloride | 3493-12-7 | 50g | $439 | 2026-06-03 | Buy |
| Usbiological | 283671 | DL-Methionine methylsulfonium chloride | 3493-12-7 | 100g | $611 | 2026-06-03 | Buy |
DL-Methionine methylsulfonium chloride Chemical Properties,Uses,Production
Preparation
1. Methionine is reacted with chloromethane under pressure and then filtered to obtain a DL-METHIONINE METHYLSULFONIUM CHLORIDE solution; 2. The DL-METHIONINE METHYLSULFONIUM CHLORIDE solution prepared in step 1 is filtered and concentrated under reduced pressure to obtain a powder; 3. The powder from step 2 is added to methanol and slurryed, then cooled until crystallization occurs, forming a DL-METHIONINE METHYLSULFONIUM CHLORIDE mixture; 4. The mixture is placed in a centrifuge, and the filter cake is washed with methanol. The filter cake is discharged when no continuous droplets flow out; 5. The filter cake is dried to obtain pharmaceutical-grade DL-METHIONINE METHYLSULFONIUM CHLORIDE.
Description
DL-Methionine methylsulfonium chloride, also named Vitamin U, is a powerful antioxidant. It is a sulfur derivative substance. Graviola leaves contain much vitamin U[1]. Vitamin U have unique antioxidant effect. It could prevents Galactosamine-induced gastric damage and protects pentylenetetrazole-induced brain damage in rats[2-3].
Uses
DL-Methionine Methylsulfonium Chloride is a compound comprised of γ-glutamyl peptide and amino acid that have a sucrose-like taste.
Uses
Vitamin U (DL-methionine methylsulfonium chloride) is a natural methionine-derivative, found as an active component in the methionine cycle of plants where it serves as a substrate for methyl transferases (Augspurger et al., 2005). Historically this compound has been utilized as either a cure or preventative against gastric and duodenal ulcers (Nakamura et al., 1981).
Biochem/physiol Actions
S-Methionine methylsulfonium (SMMS) chloride is a derivative of methionine metabolism in some plants. SMMS has potent therapeutic effects on gastrointestinal ulceration potentially via its ability to promote dermal fibroblast migration and growth.
References
[1] Choi E, et al. Increased Intestinal Absorption of Vitamin U in Steamed Graviola Leaf Extract Activates Nicotine Detoxification. Nutrients, 2019; 11.
[2] Topaloglu D, et al. Gastroprotective effect of vitamin U in D-galactosamine-induced hepatotoxicity. Journal of Biochemical and Molecular Toxicology, 2022; 36: e23124.
[3] Bayrak G, et al. The protective effect of vitamin U on pentylenetetrazole-induced brain damage in rats, 2022; 36: e23169.
DL-Methionine methylsulfonium chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Feiyue Biotechnology Co., LTD | 027-87002654 15827563343 | 3500611046@qq.com | China | 803 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6746 | 52 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
Related articles
- DL-methionine methylsulfonium chloride: Effects on Gastric Conditions and Adipocyte Differentiation
- DL-methionine methylsulfonium chloride was originally called vitamin U because of its inhibition of ulceration in the digestiv....
- Apr 1,2025
View Lastest Price from DL-Methionine methylsulfonium chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | DL-METHIONINE METHYLSULFONIUM CHLORIDE; VITAMIN U
3493-12-7
|
1KG | 99% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. | ||
 |
2026-09-11 | Vitamin U
3493-12-7
|
1kg | 98%min | 10000kg | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-01 | Vitamin U
3493-12-7
|
1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- DL-METHIONINE METHYLSULFONIUM CHLORIDE; VITAMIN U
3493-12-7
- $0.00
- 99% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- Vitamin U
3493-12-7
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Vitamin U
3493-12-7
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
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