5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
- CAS No.
- 1214377-42-0
- Chemical Name:
- 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
- Synonyms
- 5-bromo-2-methoxy-3-(triflu;2-Methoxy-3-trifluoromethyl-5-bromopyridine;5-broMo-3-(trifluoroMethyl)-2-Methoxypyridine;5-bromo-2-methoxy-3-(trifluoromethyl)pyridine;Pyridine, 5-bromo-2-methoxy-3-(trifluoromethyl)-;5-bromo-2-methoxy-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH
- CBNumber:
- CB02500898
- Molecular Formula:
- C7H5BrF3NO
- Molecular Weight:
- 256.02
- MDL Number:
- MFCD13185815
- MOL File:
- 1214377-42-0.mol
- MSDS File:
- SDS
| Boiling point | 208.0±40.0 °C(Predicted) |
|---|---|
| Density | 1.637±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | -1.38±0.20(Predicted) |
| form | liquid |
| color | Clear, colourless |
| InChI | InChI=1S/C7H5BrF3NO/c1-13-6-5(7(9,10)11)2-4(8)3-12-6/h2-3H,1H3 |
| InChIKey | ZIOFHXRZJCIBCO-UHFFFAOYSA-N |
| SMILES | C1(OC)=NC=C(Br)C=C1C(F)(F)F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H315-H319-H335 |
| Precautionary statements | P260-P271-P280 |
| HS Code | 2933399990 |
5-bromo-2-methoxy-3-(trifluoromethyl)pyridine price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FB105977 | 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine | 1214377-42-0 | 50g | $900 | 2026-06-04 | Buy |
| Biosynth | FB105977 | 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine | 1214377-42-0 | 25g | $900 | 2026-06-04 | Buy |
| Biosynth | FB105977 | 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine | 1214377-42-0 | 250g | $900 | 2026-06-04 | Buy |
| Biosynth | FB105977 | 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine | 1214377-42-0 | 10g | $900 | 2026-06-04 | Buy |
| Biosynth | FB105977 | 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine | 1214377-42-0 | 100g | $900 | 2026-06-04 | Buy |
5-bromo-2-methoxy-3-(trifluoromethyl)pyridine Chemical Properties, Uses, Production
Synthesis
121643-44-5
1214377-42-0
General procedure for the synthesis of 2-methoxy-3-trifluoromethyl-5-bromopyridine from 2-methoxy-3-trifluoromethylpyridine: 1. Trifluoroacetic acid (TFA, 80 mL) was added to a mixture of 2-methoxy-3-trifluoromethylpyridine (20.0 g, 113.0 mmol) and 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (43.6 g, 152.0 mmol), and stirred for 18 hours at room temperature under argon protection. 2. Upon completion of the reaction, the TFA was removed by distillation under reduced pressure at 50 mbar and 45 °C. The residue was suspended in tert-butyl methyl ether (200 mL), filtered to remove the resulting colorless solid, and washed with tert-butyl methyl ether (50 mL). 3. The filtrate was concentrated under reduced pressure and suspended in ethyl acetate (EtOAc, 50 mL), filtered again to remove the insoluble colorless solid, and washed with ethyl acetate (50 mL). 4. The filtrate was concentrated under reduced pressure, diluted with heptane/tert-butyl methyl ether (5:1, 20 mL), and filtered to remove the insoluble colorless solid. 5. The filtrate was purified by silica gel column chromatography with heptane/ethyl acetate (100/0 to 90/10) as eluent. 6. The crude product was filtered through a plug of sodium bicarbonate (NaHCO3, 20 g) and the filtrate was evaporated under reduced pressure to give a golden yellow oil (27.9 g). 7. The oily substance was dissolved in heptane (20 mL), purified by filtration through a plug of silica gel (80 g), and eluted with heptane to afford 5-bromo-2-methoxy-3-trifluoromethylpyridine as a colorless oil (22.5 g, 74% yield). 1H-NMR (400MHz, DMSO-d6, 298K): δ 4.03 (s, 3H), 7.95 (d, 1H), 8.4 (d, 1H).
References
[1] Patent: WO2012/4299, 2012, A1. Location in patent: Page/Page column 66-67
[2] Patent: WO2013/1445, 2013, A1. Location in patent: Page/Page column 37
[3] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 73; 74
[4] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0806
[5] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 45
5-bromo-2-methoxy-3-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-81120477 17792793610 | 1033@dideu.com | China | 9990 | 58 |
| PharmaHands (Taizhou) Co., Ltd. | 0523-86200360 18994667002 | sales@pharmahands.com.cn | China | 18 | 60 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 9993 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| ChengDu TongChuangYuan Pharmaceutical Co.Ltd | 28-83379370 13880556291 | tcy@tcypharm.com | China | 509 | 57 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
View Latest Price from 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
1214377-42-0
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-18 | 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
1214377-42-0
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-05-15 | 5-bromo-2-methoxy-3-(triflu
1214377-42-0
|
$1.50 | 1g | 99.0% Min | 100 Tons | Shaanxi Didu New Materials Co. Ltd |
-
- 5-bromo-2-methoxy-3-(trifluoromethyl)pyridine
1214377-42-0
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- 5-Bromo-2-methoxy-3-(trifluoromethyl)pyridine
1214377-42-0
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 5-bromo-2-methoxy-3-(triflu
1214377-42-0
- $1.50
- 99.0% Min
- Shaanxi Didu New Materials Co. Ltd
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