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2-Methoxypyrimidine-5-boronic acid

2-Methoxypyrimidine-5-boronic acid Structure
2-Methoxypyrimidine-5-boronic acid structure
CAS No.
628692-15-9
Chemical Name:
2-Methoxypyrimidine-5-boronic acid
Synonyms
2-METHOXYL-5-PYRIMIDYLBORIC ACID;2-Methoxypyrimidine-5-boronicaci;2-Methoxy PyriMidine boronic acid;2-Methoxy-5-pyriMidylboronic Acid;2-METHOXYL-5-PYRIMIDINEBORIC ACID;2-METHOXY-5-PYRIMIDINEBORONIC ACID;2-METHOXYPYRIMIDINE-5-BORONIC ACID;2-MethoxypyriMidine-4-boronic acid;2-METHOXYPYRIMIDIN-5-YLBORONIC ACID;2-Methoxy-5-pyrimidinylboronic Acid
CBNumber:
CB0763158
Molecular Formula:
C5H7BN2O3
Molecular Weight:
153.93
MDL Number:
MFCD03094664
MOL File:
628692-15-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-02 10:24:10
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2-Methoxypyrimidine-5-boronic acid Properties

Melting point 161°C(lit.)
Boiling point 378.3±52.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility soluble in Methanol
pka 5.59±0.11(Predicted)
form powder to crystal
color White to Light yellow
InChI InChI=1S/C5H7BN2O3/c1-11-5-7-2-4(3-8-5)6(9)10/h2-3,9-10H,1H3
InChIKey YPWAJLGHACDYQS-UHFFFAOYSA-N
SMILES B(C1=CN=C(OC)N=C1)(O)O
CAS DataBase Reference 628692-15-9(CAS DataBase Reference)
UNSPSC Code 12352106
NACRES NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P280-P301+P312-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36-41-36/37/38
Safety Statements  26-39-36/37/39
WGK Germany  WGK 3
HazardClass  IRRITANT
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2

2-Methoxypyrimidine-5-boronic acid price More Price(87)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SYX00276 2-Methoxypyrimidine-5-boronic acid 628692-15-9 1g $77.9 2026-04-30 Buy
TCI Chemical M2335 2-Methoxy-5-pyrimidylboronic Acid (contains varying amounts of Anhydride) 628692-15-9 1g $32 2026-04-30 Buy
TCI Chemical M2335 2-Methoxy-5-pyrimidylboronic Acid (contains varying amounts of Anhydride) 628692-15-9 5g $108 2026-04-30 Buy
Usbiological 281811 2-Methoxypyrimidine-5-boronic acid Asreported 628692-15-9 1g $322 2026-06-03 Buy
Usbiological 281811 2-Methoxypyrimidine-5-boronic acid Asreported 628692-15-9 2g $452 2026-06-03 Buy
Product number Packaging Price Buy
SYX00276 1g $77.9 Buy
M2335 1g $32 Buy
M2335 5g $108 Buy
281811 1g $322 Buy
281811 2g $452 Buy

2-Methoxypyrimidine-5-boronic acid Chemical Properties, Uses, Production

Chemical Properties

Off-white to light yellow solid

Uses

2-Methoxypyrimidine-5-boronic acid serves as a coupling partner in Suzuki–Miyaura reactions to synthesize diverse heterocyclic scaffolds. It reacts with intermediates such as compound 26 or 6-bromo-3-(4-hydroxyphenyl)-coumarin using potassium carbonate and palladium catalysts (e.g., Pd(OAc)₂ or 1,1′-bis(di-tert-butylphosphino)ferrocene palladium dichloride) in solvents including DMF or deep eutectic systems at 85 °C. The reagent also couples with 2-(4-((4-chloro-6-morpholino-1,3,5-triazin-2-yl)amino)phenyl)ethan-1-ol in DME/aqueous sodium carbonate under microwave heating[1][2][3]. The compound participates in Liebeskind–Srögl couplings with thioester or amide intermediates (such as series 18a–18c or 20a–20f) using tetrakis(triphenylphosphine)palladium(0) and copper(I) thiophene-2-carboxylate in THF at 100 °C, yielding target products in ranges of 22–55% or 29–50%[1].

Production Methods

5-Bromo-2-methoxypyrimidine could synthesize 2-Methoxypyrimidine-5-boronic acid as the start material.

References

[1]Wang, H., Liao, W., Li, Y., Guo, A., Liu, Z., Guo, X., Wang, K., Zheng, Y., Wang, Z., Wang, W., Wang, X., Zhang, L., Sun, Q., & Huang, Z. (2026). Discovery of Novel Thiazolo[4,5- <i>d</i> ]pyrimidin-7(6 <i>H</i> )-Ones as Extrasynaptic δ-GABA <sub>A</sub> Receptor-Preferring PAMs with Rapid Antidepressant-like Efficacy. Journal of Medicinal Chemistry, 69(14), 16476–16508. https://doi.org/10.1021/acs.jmedchem.5c03830
[2]Nelson, R. A., Jr., Schronce, T., Huang, Y., Albugami, A., Kulik, G., & Welker, M. E. (2018). Synthesis and PI 3-Kinase Inhibition Activity of Some Novel 2,4,6-Trisubstituted 1,3,5-Triazines. Molecules, 23(7), 1628. https://doi.org/10.3390/molecules23071628
[3]Katopodi, A., Nikolaou, N., Kakokefalou, V., Alexandratou, E., Matzapetakis, M., Zervou, M., & Detsi, A. (2024). A Ligand-Free Approach towards Coumarin Analogs via Natural Deep Eutectic Solvent-Mediated Suzuki–Miyaura Coupling. Molecules, 29(18), 4398. https://doi.org/10.3390/molecules29184398

2-Methoxypyrimidine-5-boronic acid Preparation Products And Raw materials

Raw materials

Nitrogen 2-Methylthiopyridine Toluene Chloramine-T trihydrate Carbon tetrachloride
Hydrogen bromide Tetrahydrofuran Hydrochloric acid 5-Bromo-2-methoxypyrimidine Bromine
Triisopropyl borate Acetic acid Methanol n-Butyllithium

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Preparation Products

2-methoxy-5-nitropyrimidine

2-Methoxypyrimidine-5-boronic acid Suppliers

Global Suppliers ( 246)
Supplier Tel Email Country ProdList Advantage
Nanjing Raise Pharmatech Co., Ltd. 025-58649566 15005191108 sales@njboyuanchem.com China 113 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 45000 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11775 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16307 64
Supplier Advantage
Nanjing Raise Pharmatech Co., Ltd. 60
J & K SCIENTIFIC LTD. 76
INTATRADE GmbH 66
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Beijing Ouhe Technology Co., Ltd 60
Pure Chemistry Scientific Inc. 62
Shanghai Longsheng chemical Co.,Ltd. 59
Nanjing Chemlin Chemical Co., Ltd 64

View Latest Price from 2-Methoxypyrimidine-5-boronic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methoxypyrimidine-5-boronic acid pictures 2026-09-20 2-Methoxypyrimidine-5-boronic acid
628692-15-9
 1G 98% 2000 Shenzhen Nexcon Pharmatechs Ltd.
2-Methoxypyrimidine-5-boronic acid pictures 2025-04-04 2-Methoxypyrimidine-5-boronic acid
628692-15-9
 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
2-Methoxypyrimidine-5-boronic acid pictures 2021-08-12 2-Methoxypyrimidine-5-boronic acid
628692-15-9
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

2-Methoxypyrimidine-5-boronic acid Spectrum

2-Methoxypyrimidine-5-boronic acid(628692-15-9)1HNMR

628692-15-9 (2-Methoxypyrimidine-5-boronic acid) Related Search:

p-Anisaldehyde p-Anisidine 3-(Methoxymethoxy)benzaldehyde (Trifluoromethoxy)benzene 4-Methoxybenzylchloride
4-Methoxyphenylacetone Ethyl 2-(Chlorosulfonyl)acetate Anisole Ascoric Acid 5-Pyrimidinylboronic acid
2,4-Dimethoxyprimidine-5-boronic acid 2,4-Di(tert-butoxy)pyrimidin-5-ylboronic acid hydrate 2,4-Bis-(benzyloxy)-5-(5,5-dimethyl-[1,3,2]-dioxaborinan-2-yl)pyrimidine 2,4-Bis(benzyloxy)pyrimidine-5-boronic acid [2-(2,2,2-Trifluoroethoxy)pyrimidin-5-yl]boronic acid
2-Phenoxypyrimidine-5-boronic acid pinacol ester 2,4-Dimethoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrimidine [2-(Trifluoromethoxy)pyrimidin-5-yl]boronic acid

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2-METHOXY-5-PYRIMIDINEBORONIC ACID 2-METHOXYPYRIMIDIN-5-YLBORONIC ACID 2-METHOXYPYRIMIDINE-5-BORONIC ACID 2-methoxypyrimidin-5-yl-5-boronic acid 2-Methoxy-5-pyriMidylboronic Acid (contains varying aMounts of Anhydride) 5-Borono-2-methyoxypyrimidine, 5-Borono-2-methoxy-1,3-diazine 2-METHOXYL-5-PYRIMIDYLBORIC ACID Boronic acid, B-(2-methoxy-5-pyrimidinyl)- 19 2-Methoxy Pyrimidine boronic acid 2-Methoxy PyriMidine boronic acid 2-Methoxypyrimidine-5-boronic acid ,98% 2-MethoxypyriMidine-4-boronic acid 2-Methoxy-5-pyriMidylboronic Acid 2-METHOXYL-5-PYRIMIDINEBORIC ACID Boronic acid, (2-methoxy-5-pyrimidinyl)- 2-Methoxypyrimidine-5-boronicaci 2-Methoxy-5-pyrimidinylboronic Acid 2-Methoxypyrimidine-5-boronic acid ISO 9001：2015 REACH B-(2-Methoxy-5-pyrimidinyl)boronic acid 2-methoxypyrryrimidine-5-boronic acid B-(2-Methoxy-pyrimidin-5-yl)boronic acid Calcium chloride anhydrous, for cell culture 628692-15-9 C5H7BN2O3 Boronate Ester Potassium Trifluoroborate Boronic acid Organoborons Pyrimidine