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Tubulin Polymerization Inhibitor II

Tubulin Polymerization Inhibitor II Structure
Tubulin Polymerization Inhibitor II structure
CAS No.
1151995-69-5
Chemical Name:
Tubulin Polymerization Inhibitor II
Synonyms
Tubulin inhibitor 9;Tubulin Polymerization Inhibitor II;2H-Indol-2-one, 1,3-dihydro-6-methoxy-3-[(3,4,5-trimethoxyphenyl)methylene]-
CBNumber:
CB02501835
Molecular Formula:
C19H19NO5
Molecular Weight:
341.36
MDL Number:
MOL File:
1151995-69-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:02
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Tubulin Polymerization Inhibitor II Properties

Boiling point 549.5±50.0 °C(Predicted)
Density 1.241±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility DMSO: 10mg/mL
form Yellow solid
pka 12.16±0.20(Predicted)
color yellow
InChI 1S/C19H19NO5/c1-22-12-5-6-13-14(19(21)20-15(13)10-12)7-11-8-16(23-2)18(25-4)17(9-11)24-3/h5-10H,1-4H3,(H,20,21)
InChIKey YLUHXAHNPQALMQ-UHFFFAOYSA-N
SMILES N1c2c(ccc(c2)OC)C(=Cc3cc(c(c(c3)OC)OC)OC)C1=O
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

Tubulin Polymerization Inhibitor II price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 654164 Tubulin Polymerization Inhibitor II 1151995-69-5 5mg $143 2026-04-30 Buy
TRC T897143 Tubulin Polymerization Inhibitor II 1151995-69-5 5mg $120 2021-12-16 Buy
Product number Packaging Price Buy
654164 5mg $143 Buy
T897143 5mg $120 Buy

Tubulin Polymerization Inhibitor II Chemical Properties, Uses, Production

Uses

Tubulin Polymerization Inhibitor II is a Tubulin inhibitor.

General Description

A cell-permeable, SU5416- (Cat. Nos. 676487 and 676498) derived combretastatin A-4 (Cat. No. 234200) analog that acts as an effective anti-microtubule agent (IC50 = 4.5 μM in inhibiting polymerization of purified porcine brain tubulin) and displays extremely potent anti-proliferative activity towards various cancer cell lines (GI50<10 nM for 46 lines among a 53 NCI panel tested).

Biochem/physiol Actions

Cell permeable: yes

Tubulin Polymerization Inhibitor II Preparation Products And Raw materials

Raw materials

Preparation Products

Tubulin Polymerization Inhibitor II Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Jinan ponder chemical co. LTD 0531-0000 thinklifescience@163.com China 19684 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
TargetMol 400-821-0310 15002144251 xuexiang.shao@tsbiochem.com China 29128 58
Supplier Advantage
VDM Biochemicals 64
Sigma-Aldrich 80
Jinan ponder chemical co. LTD 58
Energy Chemical 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
TargetMol 58

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Tubulin Polymerization Inhibitor II 2H-Indol-2-one, 1,3-dihydro-6-methoxy-3-[(3,4,5-trimethoxyphenyl)methylene]- Tubulin inhibitor 9 1151995-69-5 Angiogenesis and Metastasis Growth Factors and Cytokines