ChemicalBook >> CAS DataBase List >>(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate structure

CAS No.: 174649-09-3

Chemical Name:: (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

Synonyms: Linezolid related Compound;Linezolid USP RC D;Unezolld Impurlty 47;Linezolid Impurity 32;Mesylate imp USP RC-D;Linezolid Impurity1318;Linezolid impurity D RS;Linezolid impurity (L-0720);Linezolid Related Compound 1;Linezolid USP Related Compound D

CBNumber:: CB02510028

Molecular Formula:: C15H19FN2O6S

Molecular Weight:: 374.38

MDL Number:: MFCD18070719

MOL File:: 174649-09-3.mol

MSDS File:: SDS

Last updated:2026-05-27 17:25:06

Request For Quotation

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Properties

Melting point	183-185℃
Boiling point	592.7±50.0 °C(Predicted)
Density	1.418
storage temp.	2-8°C
solubility	Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	5.71±0.40(Predicted)
color	White to Off-White
Major Application	pharmaceutical
InChI	1S/C15H19FN2O6S/c1-25(20,21)23-10-12-9-18(15(19)24-12)11-2-3-14(13(16)8-11)17-4-6-22-7-5-17/h2-3,8,12H,4-7,9-10H2,1H3/t12-/m1/s1
InChIKey	UCVIKCGVGWBTTI-GFCCVEGCSA-N
SMILES	Fc1c(ccc(c1)N3C[C@@H](OC3=O)CO[S](=O)(=O)C)N2CCOCC2
FDA UNII	D02QUU2JKY
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
WGK Germany	WGK 3
HS Code	2934990002
Storage Class	11 - Combustible Solids

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	IF58046	(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate	174649-09-3	5g	$188.45	2026-06-04	Buy
Biosynth	IF58046	(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate	174649-09-3	10g	$314.1	2026-06-04	Buy
Biosynth	IF58046	(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate	174649-09-3	25g	$471	2026-06-04	Buy
Biosynth	IF58046	(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate	174649-09-3	50g	$628.5	2026-06-04	Buy
Biosynth	IF58046	(R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate	174649-09-3	100g	$865	2026-06-04	Buy

Product number	Packaging	Price	Buy
IF58046	5g	$188.45	Buy
IF58046	10g	$314.1	Buy
IF58046	25g	$471	Buy
IF58046	50g	$628.5	Buy
IF58046	100g	$865	Buy

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Chemical Properties,Uses,Production

Uses

(5R)-3-[3-Fluoro-4-(4-morpholinyl)phenyl]-5-[[(methylsulfonyl)oxy]methyl]-2-oxazolidinone (Linezolid USP Related Compound D) is an intermediate in the synthesis of Linezolid Dimer (L466520), an impurity of the antibacterial agent Linezolid (L466500).

Synthesis

124-63-0

(5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

168828-82-8

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate

174649-09-3

To a 1L solution of dichloromethane containing 132.8 g of (R)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-5-hydroxymethyl-2-oxazolidinone and 87.1 g of triethylamine was slowly added 74 g of methanesulfonyl chloride at 0°C under nitrogen protection. The reaction mixture was stirred at 0 °C for 30 min and then gradually warmed up to room temperature. A white solid precipitated during the reaction. Subsequently, a solvent mixture consisting of 1.75 L of water, 6.50 L of dichloromethane and 1 L of ethyl acetate was added to the reaction system and stirring was continued for 30 minutes. Upon completion of the reaction, the white solid product was collected by filtration. A final product of 140 g was obtained with a yield of 105.42% (w/w).

References

[1] Patent: WO2009/63505, 2009, A2. Location in patent: Page/Page column 14
[2] Patent: EP2163547, 2010, A1. Location in patent: Page/Page column 8
[3] Patent: WO2011/77310, 2011, A1. Location in patent: Page/Page column 12; 13
[4] Synthetic Communications, 2010, vol. 40, # 6, p. 789 - 798
[5] Patent: WO2010/84514, 2010, A2. Location in patent: Page/Page column 15

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate synthesis

Synthesis of (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate from Methanesulfonyl chloride and (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Preparation Products And Raw materials

Raw materials

Carbamic acid, [3-fluoro-4-(4-morpholinyl)phenyl](3-oxopropyl)-, phenylmethyl ester (9CI) Linezolid Impurity 8 (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione 3-Fluoro-4-morpholin-4-yl-phenylamine 4-(2-Fluoro-4-nitro-phenyl)-morpholine

3,4-Difluoronitrobenzene Methanesulfonyl chloride Triethylamine Dichloromethane

1of2

Preparation Products

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Suppliers

Global( 171)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Longsheng chemical Co.,Ltd.	58099637 13585536065	sales@shlschem.com	China	9880	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6746	52
Daicel Chiral Technologies (China)CO.,LTD	021-50460086-9 15921403865	han_yajun@dctc.daicel.com	China	7909	65
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Adamas Reagent, Ltd.	59
Shanghai Longsheng chemical Co.,Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
XiaoGan ShenYuan ChemPharm co,ltd	52
Daicel Chiral Technologies (China)CO.,LTD	65
Tianjin heowns Biochemical Technology Co., Ltd.	57
BOC Sciences	65
T&W GROUP	58

View Lastest Price from (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-13	(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 174649-09-3			0.99		RongNa Biotechnology Co.,Ltd
2026-08-25	(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate 174649-09-3	$2.20-8.80	1kg	99%min	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2019-07-06	(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 174649-09-3	$2.00	1kg	99%		Career Henan Chemical Co

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
174649-09-3
0.99
RongNa Biotechnology Co.,Ltd

(R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate
174649-09-3
$2.20-8.80
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate
174649-09-3
$2.00
99%
Career Henan Chemical Co

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Spectrum

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate(174649-09-3)¹HNMR

174649-09-3((R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate)Related Search:

Linezolid Diphthalimide Linezolid (5R)-3-(3-Fluoro-4-(4-morpholinyl)phenyl)-5-hydroxymethyl-2-oxazolidione (R)-5-(Azidomethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone (S)-N-((3-(3-fluoro-4-Morpholinophenyl)-2-oxooxazolidin-5-yl)Methyl)ethanethioaMide

(S)-N-(3-Chloro-2-hydroxypropyl)acetamide 4-(2-Bromo-4-nitrophenyl)morpholine O-descarbonyl O-Acetyl Linezolid Linezolid Impurity 34 Linezolid Impurity 11

2-amino-3-chloropropan-1-ol hydrochloride (R)-1-Amino-3-chloro-2-propanol hydrochloride N-[(2R)-3-[[3-Fluoro-4-(4-Morpholinyl)phenyl]aMino]-2-hydroxypropyl]acetaMide N-(3-PhthaliMido-2-(R)-hydroxypropyl)-3-fluoro-4-(Morpholinyl)aniline 1-ACETAMIDO-ACETONE

N-[[(5R)-3-[3-Fluoro-4-(4-Morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]Methyl]acetaMide Bis-Linezolid 3-Fluoro-4-morpholin-4-yl-phenylamine

1of4

(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate (R)-[3-(3-Fluoro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl]Methyl Methanesulfonat (R)-(3-(3-flouro-4-Morpholinophenyl)-2-oxo-5-oxazolidinyl)Methyl Methanesulfonate (R)-(3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl methanesulfonate (5R)-3-[3-Fluoro-4-(4-Morpholinyl)phenyl]-5-[[(Methylsulfonyl)oxy]Methyl]-2-oxazolidinone 2-Oxazolidinone, 3-[3-fluoro-4-(4-Morpholinyl)phenyl]-5-[[(Methylsulfonyl)oxy]Methyl]-, (5R)- Linezolid related Compound Linezolid USP RC D (R)-N-(3-(3-Fluoro-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methanol mesylate Linezolid Impurity 32 (R)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl)methyl methansulfonate Linezolid USP Related Compound D Linezolid Related Compound 1 Linezolid Related Compound D (Linezolid Mesylate Impurity) Mesylate imp USP RC-D (R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]me... Linezolid Impurity1318 TIANFU-CHEM --(R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate Unezolld Impurlty 47 (R) - N - [3- (3-fluoro - (4-morpholino) phenyl) -2-oxo-5-oxazolyl] methanesulfonate (R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl (5R)-[3-(3-Fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl]methyl Methanesulfonate (R)-N-[3-(3-Fluoro-4-(morpholin-4-yl)phenyl)-2-oxo-5-oxazolidinyl]methanolMethanesulfonate (R)-(3-(3-FLUORO-4-MORPHOLINOPHENYL)-2- OXOOXAZOLIDIN-5-YL)METHYL METHANESULFONATE / LINEZOLID RELATED COMPOUND D Linezolid impurity D RS (R)-N-[3-(3-Fluoro-4-morpholinophenyl)-2-oxo-5-oxazolidinyl]methanol methanesulfonate Linezolid impurity (L-0720) (R)-[3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 174649-09-3 185608-75-8