3-Fluoro-4-morpholin-4-yl-phenylamine
- CAS No.
- 93246-53-8
- Chemical Name:
- 3-Fluoro-4-morpholin-4-yl-phenylamine
- Synonyms
- 3-FLUORO-4-MORPHOLINOANILINE;Linezolid AMine IMpurity;3-fluoro-4-morpholin-4-ylaniline;AKOS B033533;TIMTEC-BB SBB010944;Linezolid Impurity 28;Linezolid Intermediate 1;3-Fluoro-4-morpholinoanili;3-Fluoro-4-morpholin-4-yl-;3-FLUORO-4-MORPHOLIN-ANILINE
- CBNumber:
- CB1698428
- Molecular Formula:
- C10H13FN2O
- Molecular Weight:
- 196.22
- MDL Number:
- MFCD02571270
- MOL File:
- 93246-53-8.mol
- MSDS File:
- SDS
| Melting point | 121-123°C |
|---|---|
| Boiling point | 364.9±42.0 °C(Predicted) |
| Density | 1.232±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Methanol |
| form | Solid |
| pka | 6.53±0.40(Predicted) |
| color | Off-White to Brown |
| InChI | InChI=1S/C10H13FN2O/c11-9-7-8(12)1-2-10(9)13-3-5-14-6-4-13/h1-2,7H,3-6,12H2 |
| InChIKey | FQGIBHQUVCGEAC-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=C(N2CCOCC2)C(F)=C1 |
| CAS DataBase Reference | 93246-53-8(CAS DataBase Reference) |
| FDA UNII | S59MCD5UHX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2934999090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
3-Fluoro-4-morpholin-4-yl-phenylamine price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0849 | 3-Fluoro-4-morpholinoaniline >98.0%(GC)(T) | 93246-53-8 | 5g | $90 | 2026-04-30 | Buy |
| TCI Chemical | F0849 | 3-Fluoro-4-morpholinoaniline >98.0%(GC)(T) | 93246-53-8 | 25g | $271 | 2026-04-30 | Buy |
| TRC | TRC-F595895-1G | 3-Fluoro-4-(4-morpholinyl) Benzenamine | 93246-53-8 | 1g | $70 | 2026-06-03 | Buy |
| Usbiological | 012408 | 3-Fluoro-4-(4-morpholinyl) Benzenamine | 93246-53-8 | 1g | $319 | 2026-06-03 | Buy |
| Usbiological | 012408 | 3-Fluoro-4-(4-morpholinyl) Benzenamine | 93246-53-8 | 10g | $453 | 2026-06-03 | Buy |
3-Fluoro-4-morpholin-4-yl-phenylamine Chemical Properties,Uses,Production
Chemical Properties
Brown Solid
Uses
Intermediate in the synthesis of Linezolid (L466500).
Definition
ChEBI: 3-Fluoro-4-morpholinoaniline is a member of morpholines.
Synthesis
2689-39-6
93246-53-8
The general procedure for the synthesis of 3-fluoro-4-(4-morpholinyl)aniline from 3-fluoro-4-(4-morpholinyl)nitrobenzene was as follows: 4-(2-fluoro-4-nitrophenyl)morpholine D1 (42.6 g, 0.19 mol) was dissolved in ethanol (1.2 L), 10% Pd/C catalyst (4 g) was added, and hydrogenation was carried out at standard temperature and pressure (STP) for 18 hours. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was evaporated under vacuum to afford the target product 3-fluoro-4-(4-morpholinyl)aniline (36.9 g, 100% yield) as a colorless solid. The structure of the product was confirmed by 1H NMR (CDCl3): δ 2.96 (4H, m), 3.55 (2H, br s), 3.84 (4H, m), 6.41 (2H, m), 6.79 (1H, m).
References
[1] Patent: WO2005/58317, 2005, A1. Location in patent: Page/Page column 35
[2] Patent: WO2005/58885, 2005, A2. Location in patent: Page/Page column 33
[3] Patent: WO2005/75461, 2005, A1. Location in patent: Page/Page column 100
[4] Patent: WO2006/2956, 2006, A1. Location in patent: Page/Page column 31
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 9, p. 4052 - 4066
3-Fluoro-4-morpholin-4-yl-phenylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Gansu Songsheng Pharmaceutical Co. , Ltd. | 13705130158 | sales@unitechemical.com | China | 145 | 58 |
| Anqing CHICO Pharmaceutical Co., Ltd. | 18061456370 | sales@chicopharm.com | China | 500 | 65 |
| TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. | 022-60189726 18812034280 | 188120342808@163.com | China | 143 | 61 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Lastest Price from 3-Fluoro-4-morpholin-4-yl-phenylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
93246-53-8
|
1KG | 98 | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-03-20 | 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
93246-53-8
|
$1.00 | 1kg | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2020-11-16 | 3-FLUORO-4-MORPHOLIN-ANILINE
93246-53-8
|
$21.00 | 25Kg/Bag | 99% | 20 Tons | Longyan Tianhua Biological Technology Co., Ltd |
-
- 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
93246-53-8
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-FLUORO-4-MORPHOLIN-4-YL-PHENYLAMINE
93246-53-8
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 3-FLUORO-4-MORPHOLIN-ANILINE
93246-53-8
- $21.00
- 99%
- Longyan Tianhua Biological Technology Co., Ltd
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