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LDN-193189 HCl

LDN-193189 HCl Structure
LDN-193189 HCl structure
CAS No.
1062368-62-0
Chemical Name:
LDN-193189 HCl
Synonyms
CS-1451;LDN-193189 HCl;LDN-193189 4HCl;LDN-193189 HCl USP/EP/BP;LDN193189 (Hydrochloride);LDN-193189 HCL;LDN 193189 HCL;LDN-193189 HCl, 10 mM in DMSO;LDN193189 hydrochloride (LDN 193189 hydrochloride;4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl;LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE
CBNumber:
CB02517951
Molecular Formula:
C25H23ClN6
Molecular Weight:
442.94332
MDL Number:
MFCD17392570
MOL File:
1062368-62-0.mol
MSDS File:
SDS
Last updated:2026-07-23 14:48:42
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LDN-193189 HCl Properties

Melting point >240°C (dec.)
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Methanol (Slightly), DMSO (Very Slightly, Heated)
form Solid
color Dark Orange
CAS DataBase Reference 1062368-62-0
FDA UNII PLH51K438W

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

LDN-193189 HCl price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19396 LDN-193189 (hydrochloride) ≥98% 1062368-62-0 1mg $25 2021-12-16 Buy
Cayman Chemical 19396 LDN-193189 (hydrochloride) ≥98% 1062368-62-0 5mg $75 2021-12-16 Buy
TRC TRC-P480133-50MG LDN 193189 Hydrochloride 50mg $1109 2026-06-03 Buy
TRC TRC-P480133-10MG LDN 193189 Hydrochloride 10mg $262 2026-06-03 Buy
ChemScene CS-0101809 LDN193189 hydrochloride 98.62% 1062368-62-0 5mg $87 2026-06-04 Buy
Product number Packaging Price Buy
19396 1mg $25 Buy
19396 5mg $75 Buy
TRC-P480133-50MG 50mg $1109 Buy
TRC-P480133-10MG 10mg $262 Buy
CS-0101809 5mg $87 Buy

LDN-193189 HCl Chemical Properties, Uses, Production

Uses

LDN-193189 HCl has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline Hydrochoride is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases.

Biological Activity

ldn193189 is a selective transcriptional activity morphogenetic protein (bmp) type i receptors inhibitor. it inhibits activin receptor-like kinase-2 (alk2) and alk3 with ic50 values of 5 nm and 30 nm, respectively [1].ldn193189 has been showed to inhibit bmp induced phosphorylation of smad signaling (smad1/5/8) and non-smad signaling including p38 and akt in c2c12 cells [2].pharmacological inhibition of bmp by ldn193189 has shown to prevent down-regulation of e-cadherin in response to bmp2 both in bronchial epithelial (beas2b) cells and in c57bl/6 mice. ldn193189 also inhibits the bmp-induced reduction of epithelial permeability at cellular level [3].

Synthesis

tert-butyl 4-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyriMidin-6-yl)phenyl)piperazine-1-carboxylate

1062368-27-7

LDN-193189 HCl

1062368-62-0

Compound 18a (640 mg, 1.26 mmol) was taken as raw material and dissolved in methanol (10 mL) and 1,4-dioxane solution (6.3 mL) in 4M HCl was added. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, the mixture was concentrated to dryness. The resulting residue was washed with a small amount of methanol to afford the target product 13-HCl (550 mg, 98% yield) as a yellow solid. The product was characterized by 1H NMR (DMSO-d6): δ 9.75 (d, J = 2.2 Hz, 1H), 9.40 (br.s, 1H), 9.29 (d, J = 5.9 Hz, 1H), 9.28 (d, J = 2.2 Hz, 1H), 9.07 (s, 1H), 8.70 (d, J = 8.4 Hz, 1H), 8.51 (d, J = 5.9 Hz, 1H), 8.47 (d, J = 8.4 Hz, 1H), 8.21 (t, J = 7.6 Hz, 1H), 7.99 (t, J = 7.6 Hz, 1H), 7.88 (d, J = 8.8 Hz, 2H), 7.19 (d, J = 8.8 Hz, 2H), 3.51-3.58 (m, 4H), 3.20- 3.30 (m, 4H). The molecular ion peak m/z was determined to be 407.1979 by high-resolution mass spectrometry (HRMS), which is consistent with the calculated value of 407.1979 for the theoretical value C25H23N6 (MH+).

References

[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.

LDN-193189 HCl Preparation Products And Raw materials

Raw materials

tert-butyl 4-(4-(3-(quinolin-4-yl)pyrazolo[1,5-a]pyriMidin-6-yl)phenyl)piperazine-1-carboxylate 1,4-Dioxane Hydrochloric acid

Preparation Products

LDN-193189 HCl Suppliers

Global Suppliers ( 127)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Shangchem Co., Ltd. +86-21-68182121 China 881 52
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Shangchem Co., Ltd. 52
NCE Biomedical Co.,Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
AdooQ BioScience, LLC 58
Bide Pharmatech Ltd. 60
ShangHai KenEn Chemical Technology Co., Ltd. 55
Shanghai YuLue Chemical Co., Ltd. 55

View Latest Price from LDN-193189 HCl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
LDN-193189 HCl pictures 2026-07-22 LDN-193189 HCl
1062368-62-0
 $30.00-64.00 99.49% 10g TargetMol Chemicals Inc.
LDN-193189 HCl pictures 2019-12-24 LDN-193189 HCl
1062368-62-0
 $1.00 1g 99.99% 200kg Career Henan Chemical Co

LDN-193189 HCl Spectrum

LDN-193189 HCl(1062368-62-0)1HNMR

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4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride 4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyriMidin-3-yl)quinoline HCl LDN193189 (Hydrochloride) 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline hydrochloride (1:1) LDN-193189 HCl LDN193189 hydrochloride, 98%, a selective BMP type I receptor kinases inhibitor LDN-193189 HCL;LDN 193189 HCL;LDN 193189 HYDROCHLORIDE;LDN-193189 HYDROCHLORIDE LDN-193189 HCL;LDN 193189 HCL CS-1451 LDN-193189 HCl USP/EP/BP LDN-193189 4HCl LDN-193189 HCl, 10 mM in DMSO LDN193189 hydrochloride (LDN 193189 hydrochloride 1062368-62-0 C25H26Cl4N6 C25H22N6HCl C25H22N6ClH Inhibitors