SB 431542 | 301836-41-9

SB 431542 Properties

Melting point	214 °C(dec.)
Boiling point	662.4±55.0 °C(Predicted)
Density	1.373
Flash point	354.4℃
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: 10 mg/mL, soluble
form	powder
pka	10.14±0.10(Predicted)
color	Yellow
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI	InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChIKey	FHYUGAJXYORMHI-UHFFFAOYSA-N
SMILES	C(N)(=O)C1=CC=C(C2NC(C3=NC=CC=C3)=C(C3=CC=C4OCOC4=C3)N=2)C=C1
FDA UNII	E1557V1V0N
UNSPSC Code	51111800
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P280-P305+P351+P338-P362+P364
PPE	Eyeshields, Gloves, type N95 (US)
Safety Statements	22-24/25
WGK Germany	3
HS Code	29349990
Storage Class	11 - Combustible Solids

SB 431542 price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	616464	InSolution? TGF-β RI Kinase Inhibitor VI, SB431542	301836-41-9	5mg	$175	2026-04-30	Buy
Sigma-Aldrich	616461	TGF-β RI Kinase Inhibitor VI, SB431542	301836-41-9	5mg	$193	2026-04-30	Buy
TCI Chemical	B6661	SB 431542 [Optimized for Cell Culture]	301836-41-9	5MG	$126	2026-04-30	Buy
TCI Chemical	B4003	SB 431542	301836-41-9	25MG	$241	2026-04-30	Buy
TCI Chemical	B4003	SB 431542	301836-41-9	100MG	$662	2026-04-30	Buy

Product number	Packaging	Price	Buy
616464	5mg	$175	Buy
616461	5mg	$193	Buy
B6661	5MG	$126	Buy
B4003	25MG	$241	Buy
B4003	100MG	$662	Buy

SB 431542 Chemical Properties, Uses, Production

Description

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC₅₀ = 94 nM). It is a less potent antagonist of ALK4 (IC₅₀ = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

Uses

SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells. Potent TGF-beta inhibitor.

Definition

ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.

General Description

A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 μM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC₅₀ = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC₅₀ ≥10 μM in the presence of 10 μM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220).

Biological Activity

Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.

Biochem/physiol Actions

SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.

storage

Room temperature

Background

SB431542 is a potent and selective ATP-competitive inhibitor of the transforming growth factor β1 activin receptor-like kinases -4, -5, and -7. Research studies using cell-free kinase assays show that SB431542 inhibits ALK4 and ALK5 with IC50 values of 140 nM and 94 nM, respectively, and ALK7 with slightly less potency. The SB431542 inhibitor displays a 100-fold greater selectivity for ALK5 than 25 other kinases, including p38 MAPK and JNK1. SB431542 inhibits Smad2 signaling induced by TGF-β and activin, but has no effect on BMP-induced Smad1 activation mediated by ALK -2, -3, and -6. Additional studies show that SB431542 enhances the proliferation and integrity of ESC-derived endothelial cells.

References

[1] N J LAPING. Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.[J]. Molecular Pharmacology, 2002, 62 1 1: 58-64. DOI:10.1124/mol.62.1.58
[2] GARETH J INMAN. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.[J]. Molecular Pharmacology, 2002, 62 1 1: 65-74. DOI:10.1124/mol.62.1.65
[3] SHIGEO MATSUYAMA. SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.[J]. Cancer research, 2003, 63 22: 7791-7798.
[4] TETSURO WATABE. TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells.[J]. Journal of Cell Biology, 2003, 163 6: 1303-1311. DOI:10.1083/jcb.200305147
[5] NANCY STANSLOWSKY. Functional differentiation of midbrain neurons from human cord blood-derived induced pluripotent stem cells.[J]. Stem Cell Research & Therapy, 2014, 5 2: 35. DOI:10.1186/scrt423

SB 431542 Preparation Products And Raw materials

Raw materials

Preparation Products

SB 431542 Suppliers

Global Suppliers ( 318)

Supplier	Tel	Email	Country	ProdList	Advantage
Dezhou LonWel Pharmaceutical Technology Co., Ltd.	13761310616	39324283@qq.com	China	1359	58
AdooQ Bioscience CHINA	025-58849295	info@adooq.cn	China	2981	60
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Ascent Scientific	4401179829988	customerservice@ascentscientific.co.uk	United Kingdom	279	60
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50

Supplier	Advantage
Dezhou LonWel Pharmaceutical Technology Co., Ltd.	58
AdooQ Bioscience CHINA	60
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chembest Research Laboratories Limited	61
Ascent Scientific	60
VDM Biochemicals	64
Nanjing Chemlin Chemical Co., Ltd	64
Chemsky（shanghai）International Co.,Ltd.	50

View Latest Price from SB 431542 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	SB-431542 301836-41-9	$50.00-296.00		99.03%	10g	TargetMol Chemicals Inc.

SB-431542
301836-41-9
$50.00-296.00
99.03%
TargetMol Chemicals Inc.

SB 431542 Spectrum

SB 431542(301836-41-9)MS SB 431542(301836-41-9)¹HNMR

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SB-431542/SB431542 SB 431542, >=98% 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542 SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate SB 431542 4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE 4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE InSolution? TGF-β RI Kinase Inhibitor VI, SB431542 TGF-β RI Kinase Inhibitor VI, SB431542 SB 431542 HYDRATE Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]- 4-(5-benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1h-imidazol-2-yl)-benzamide hydrate 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate SB 431542 hydrate,4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate 4-(4-(Benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imid TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem CS-89 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide 4-[4-(2H-1,3-benzodioxol-5-yl)-5-(pyridin-2-yl)-1H-iMidazol-2-yl]benzaMide 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide SB 431542, 98%, a potent and selective inhibitor of ALK5 SB 431542USP/EP/BP 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide TGF-β RI Kinase Inhibitor VI SB431542 SB-431542 Transforming growth factor beta receptors,inhibit,TGF-β Receptor,SB-431542,SB431542,Inhibitor SB-431542 (Standard) SB-431542, Sterile-Filtered SB431542 (DMSO solution), ALK inhibitor SB431542, ALK inhibitor SB 431542/4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide SB-431542, 10 mM in DMSO TGF-β RI Kinase Inhibitor VI, SB431542 4-[4-(1,3-benzenebenzodiazole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl]-benzeneamide 301836-41-9 C22H16N4O3xH2O Csub2subsub2subHsub1subsub6subNsub4subOsub3sub Cell Biology Cell Signaling and Neuroscience BioChemical Cytokines, Growth Factors and Hormones Cytokines and Growth Factors Inhibitors Anti-cancer&immunity Smad TGF-beta Protein Kinase Signalling