4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- CAS No.
- 15427-93-7
- Chemical Name:
- 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate
- Synonyms
- DDUG diMS;NSC 109555;NSC109555 Dimesylate;NSC 109555 ditosylate;DDUG dimethanesulfonate;4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate;2,2′-[Carbonylbis(imino-4,1-phenyleneethylidyne)]-bis-Hydrazinecarboximidamide methanesulfonate (1:2)
- CBNumber:
- CB02518817
- Molecular Formula:
- C20H28N10O4S
- Molecular Weight:
- 504.56592
- MDL Number:
- MOL File:
- 15427-93-7.mol
- MSDS File:
- SDS
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0781 | NSC109555 ≥98% (HPLC) | 15427-93-7 | 5mg | $95.7 | 2022-05-15 | Buy |
| Sigma-Aldrich | SML0781 | NSC109555 ≥98% (HPLC) | 15427-93-7 | 25mg | $377 | 2022-05-15 | Buy |
| Cayman Chemical | 19811 | NSC 109555 ≥98% | 15427-93-7 | 1mg | $28 | 2026-04-30 | Buy |
| Cayman Chemical | 19811 | NSC 109555 ≥98% | 15427-93-7 | 5mg | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 19811 | NSC 109555 ≥98% | 15427-93-7 | 10mg | $154 | 2026-04-30 | Buy |
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Chemical Properties, Uses, Production
Uses
NSC 109555 is an inhibitor of checkpoint kinase 2 (Chk2), a serine/threonine kinase involved in the ATM-Chk2 checkpoint pathway. Drugs that target Chk2 in combination with DNA-damaging agents can be beneficial in cancer therapy. Studies in mice, rats, rabbits, dogs, and monkeys have shown that NSC 109555 displays toxic effects. A singe injection of the drug at a concentration of 12.5-25 mg/kg caused acute paralysis leading to apnea and death.
Biochem/physiol Actions
NSC109555 is a selective inhibitor of Chk2 (IC50 = 310 nM). The compound is reversible and competitive for ATP, and displays little or no activity against other related kinases, including Chk1, at concentrations up to 10 μM.
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Preparation Products And Raw materials
Raw materials
Preparation Products
4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
View Latest Price from 4,4'-diacetyldiphenylureabis(guanylhydrazone)ditosylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | NSC 109555
15427-93-7
|
$91.00-497.00 | 10g | TargetMol Chemicals Inc. |
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- NSC 109555
15427-93-7
- $91.00-497.00
- TargetMol Chemicals Inc.
