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PF03716556

PF03716556 structure

CAS No.: 928774-43-0

Chemical Name:: PF03716556

Synonyms: CS-1022;PF 3716556;PF03716556;PF-3716556 ，S2222;PF03716556 USP/EP/BP;PF-3716556 PF3716556;PF-03716556; PF03716556;PF 03716556, 10 mM in DMSO;PF3716556/PF-3716556/PF-03716556;PF-3716556;PF-03716556; PF03716556

CBNumber:: CB02526164

Molecular Formula:: C22H26N4O3

Molecular Weight:: 394.47

MDL Number:: MFCD19690947

MOL File:: 928774-43-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:25:35

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PF03716556 Properties

Melting point	143-145°C
Density	1.30
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	DMSO: ≥10mg/mL
form	powder
pka	14.18±0.10(Predicted)
color	white to tan
InChI	1S/C22H26N4O3/c1-14-5-4-6-19-20(14)17(7-10-29-19)24-18-11-16(22(28)25(3)8-9-27)13-26-12-15(2)23-21(18)26/h4-6,11-13,17,24,27H,7-10H2,1-3H3/t17-/m1/s1
InChIKey	YBHKBMJREUZHOV-QGZVFWFLSA-N
SMILES	CN(CCO)C(=O)c1cc(N[C@@H]2CCOc3cccc(C)c23)c4nc(C)cn4c1
FDA UNII	701L6668UD
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H317-H319
Precautionary statements	P280-P305+P351+P338
WGK Germany	3
Storage Class	11 - Combustible Solids

PF03716556 price More Price(50)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PZ0155	PF-03716556 ≥98% (HPLC)	928774-43-0	5mg	$117	2024-03-01	Buy
Sigma-Aldrich	PZ0155	PF-03716556 ≥98% (HPLC)	928774-43-0	25mg	$545	2023-06-20	Buy
Cayman Chemical	17710	PF-3716556 ≥98%	928774-43-0	5mg	$69	2026-04-30	Buy
Cayman Chemical	17710	PF-3716556 ≥98%	928774-43-0	10mg	$120	2026-04-30	Buy
Cayman Chemical	17710	PF-3716556 ≥98%	928774-43-0	25mg	$248	2026-04-30	Buy

Product number	Packaging	Price	Buy
PZ0155	5mg	$117	Buy
PZ0155	25mg	$545	Buy
17710	5mg	$69	Buy
17710	10mg	$120	Buy
17710	25mg	$248	Buy

PF03716556 Chemical Properties, Uses, Production

Chemical Properties

Light Tan Solid

Uses

A novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

Biological Activity

the gastric h+,k+-atpase, which is responsible for gastric acid secretion, is a p2-type atpase located in the apical membrane of parietal cells. inhibition of the h+,k+-atpase is currently the most effective way to control gastric acid secretion and remains an attractive target for the medical treatment of acidrelated diseases. pf-03716556 is a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

in vitro

pf-03716556 demonstrated 3-fold greater inhibitory activity than revaprazan, the only acid pump antagonist that has been available on the market, in ion-tight assay. kinetics experiments revealed that pf-03716556 has a competitive and reversible mode of action [1].

in vivo

pf-03716556 did not display any species differences, exhibiting highly selective profile including the canine kidney h+,k+-atpase. in addition, more rapid onset of action than omeprazole and 3-fold greater potency than revaprazan were observed in ghosh-schild rats and heidenhain pouch dogs [2].

IC 50

in porcine ion-tight membrane vesicles, pf-03716556 inhibited h+,k+-atpase activity in a concentration-dependent manner, with a pic50 value of 7.095 ± 0.077 at ph 7.4.

storage

-20°C

References

[1] mori h, tonai-kachi h, ochi y, taniguchi y, ohshiro h, takahashi n, aihara t, hirao a, kato t, sakakibara m, kurebayashi y. n-(2-hydroxyethyl)-n,2-dimethyl-8-{[(4r)-5-methyl-3,4- dihydro-2h-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (pf-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. j pharmacol exp ther. 2009;328(2):671-9.

PF03716556 Preparation Products And Raw materials

Raw materials

Preparation Products

PF03716556 Suppliers

Global Suppliers ( 95)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
China DongFan Chemical Co.,LTD	86-0571-85151182		China	5681	66
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4761	58
NCE Biomedical Co.,Ltd.	4000-027-021 \|24 +86-13986109188 \| +86-15623472865 \| +81-08033611988		China	1490	55
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29975	65
EnliPharma Technology Co., Ltd	0551-66399836 18955197623	sales@enlipharma.com	China	1875	55
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2774	58

Supplier	Advantage
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
China DongFan Chemical Co.,LTD	66
BOC Sciences	65
Dalian Meilun Biotech Co., Ltd.	58
NCE Biomedical Co.,Ltd.	55
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
EnliPharma Technology Co., Ltd	55
AdooQ BioScience, LLC	58

View Latest Price from PF03716556 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-06	PF 03716556 928774-43-0	$35.00-88.00		99.91%	10g	TargetMol Chemicals Inc.

PF 03716556
928774-43-0
$35.00-88.00
99.91%
TargetMol Chemicals Inc.

PF03716556 Spectrum

PF03716556(928774-43-0)¹HNMR

928774-43-0 (PF03716556) Related Search:

G-STROPHANTHIN PF03716556 Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4S)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl- Imidazo[1,2-a]pyridine-6-carboxamide, 8-[(3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl)amino]-N-(2-hydroxyethyl)-N,2-dimethyl- PF06869206

PF 750

1of2

8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa (R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556 [N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide] PF03716556 PF 3716556 PF-3716556;PF-03716556; PF03716556 (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca PF3716556/PF-3716556/PF-03716556 PF-03716556; PF03716556 CS-1022 Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl- PF03716556 USP/EP/BP (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide PF-3716556 PF3716556 PF 03716556, 10 mM in DMSO PF-3716556 ，S2222 928774-43-0 Amines Aromatics Heterocycles Inhibitors Intermediates & Fine Chemicals Pfizer Compounds Pharmaceuticals