6-HYDROXY-2-NAPHTHALENEBORONIC ACID
- CAS No.
- 173194-95-1
- Chemical Name:
- 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
- Synonyms
- EOS-61102;AKOS BRN-0430;6-HYDROXY-2-NAPHTALENEBORONIC ACID;(6-Hydroxy-2-naphthyl)boronic acid;6-HYDROXY-2-NAPTHALENE BORONIC ACID;6-HYDROXY-2-NAPHTHYLENEBORONIC ACID;6-HYDROXY-2-NAPHTHALENEBORONIC ACID;6-HYDROXYNAPHTHALENE-2-BORONIC ACID;6-hydroxynaphthalen-2-ylboronic acid;(6-Hydroxynaphthalen-2-yl)boronicaci
- CBNumber:
- CB0253307
- Molecular Formula:
- C10H9BO3
- Molecular Weight:
- 187.99
- MDL Number:
- MFCD00092986
- MOL File:
- 173194-95-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 6-hydroxy-2-naphthaleneboronic acid AldrichCPR | CDS015293 | 100MG | $77.9 |
| 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride) | H1402 | 1g | $52 |
| 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride) | H1402 | 5g | $151 |
| 6-Hydroxy-2-naphthaleneboronic acid 97-105%(Assaybytitration) | 40165 | 1G | $106.96 |
| 6-Hydroxy-2-naphthaleneboronic acid 97-105%(Assaybytitration) | 40165 | 5G | $401.8 |
| More product size | |||
| Melting point | 218-224°C |
|---|---|
| Boiling point | 458.6±37.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 8.80±0.30(Predicted) |
| form | powder to crystal |
| color | Light yellow to Yellow to Orange |
| InChI | 1S/C10H9BO3/c12-10-4-2-7-5-9(11(13)14)3-1-8(7)6-10/h1-6,12-14H |
| InChIKey | SNJANQMHRGSHFN-UHFFFAOYSA-N |
| SMILES | OB(O)c1ccc2cc(O)ccc2c1 |
| LogP | 2.47 at 21.6℃ |
| CAS DataBase Reference | 173194-95-1(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Harmful/Irritant/Keep Cold | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
6-HYDROXY-2-NAPHTHALENEBORONIC ACID price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS015293 | 6-hydroxy-2-naphthaleneboronic acid AldrichCPR | 173194-95-1 | 100MG | $77.9 | 2026-04-30 | Buy |
| TCI Chemical | H1402 | 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride) | 173194-95-1 | 1g | $52 | 2026-04-30 | Buy |
| TCI Chemical | H1402 | 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride) | 173194-95-1 | 5g | $151 | 2026-04-30 | Buy |
| Chem-Impex | 40165 | 6-Hydroxy-2-naphthaleneboronic acid 97-105%(Assaybytitration) | 173194-95-1 | 1G | $106.96 | 2026-05-19 | Buy |
| Chem-Impex | 40165 | 6-Hydroxy-2-naphthaleneboronic acid 97-105%(Assaybytitration) | 173194-95-1 | 5G | $401.8 | 2026-05-19 | Buy |
6-HYDROXY-2-NAPHTHALENEBORONIC ACID Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
6-Hydroxynaphthalene-2-boronic acid can be used to synthesize inhibitors for oxygenase, tyrosine and phosphoinositide kinases. Tyrosine and phosphoinositide kinases are an attractive target for developing cancer drugs.
Synthesis
15231-91-1
173194-95-1
Under argon protection, 5.58 g (25 mmol) of 6-bromo-2-naphthol was dissolved in 125 mL of anhydrous tetrahydrofuran. After cooling the resulting solution to -70°C, 33 mL (55 mmol) of hexane solution of n-butyllithium was added slowly and dropwise over a period of 30 minutes. Maintaining -70°C, the reaction mixture was continued to be stirred for 1.5 hours. Subsequently, 11.5 mL (50 mmol) of triisopropyl borate was added and stirring was continued at the same temperature for 30 minutes. After that, the reaction mixture was allowed to slowly warm up to room temperature and stirred for 3 hours in the process. After completion of the reaction, 100 mL of 2 M hydrochloric acid was added to the mixture and stirred at room temperature for 2 hours. The reaction solution was separated and the aqueous phase was extracted with ethyl acetate. All organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and the solvent was subsequently evaporated. The residue was washed with dichloromethane in suspension to give 4.02 g of 6-hydroxy-2-naphthaleneboronic acid in 85% yield.
References
[1] Patent: EP2597094, 2013, A1. Location in patent: Paragraph 0093
[2] Patent: WO2007/68905, 2007, A1. Location in patent: Page/Page column 69-70
[3] Patent: US2004/44258, 2004, A1. Location in patent: Page 60
6-HYDROXY-2-NAPHTHALENEBORONIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13902 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29816 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451682 | act@arborchemical.com | CHINA | 904 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
View Lastest Price from 6-HYDROXY-2-NAPHTHALENEBORONIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | (6-Hydroxy-2-naphthyl)boronic acid
173194-95-1
|
US $200.00-1.00 / KG | 1KG | 99%, 99.5% Sublimated | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-08-12 | 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
173194-95-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-02 | 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride)
173194-95-1
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- (6-Hydroxy-2-naphthyl)boronic acid
173194-95-1
- US $200.00-1.00 / KG
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 6-HYDROXY-2-NAPHTHALENEBORONIC ACID
173194-95-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 6-Hydroxy-2-naphthaleneboronic Acid (contains varying amounts of Anhydride)
173194-95-1
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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