Methyl 3-formyl-2-nitrobenzoate
- CAS No.
- 138229-59-1
- Chemical Name:
- Methyl 3-formyl-2-nitrobenzoate
- Synonyms
- Methyl 3-formyl-2-nitrobenzoate;3-Formyl-2-nitrobenzoic acid methyl ester;Methyl 3-formyl-2-nitrobenzoate 99%;Benzoic acid, 3-forMyl-2-nitro-, Methyl ester;EOS-60871;RSYY(Roxadustat)-9;methyl 3-formyl-2-nitrobenzoa;methyl 2-nitro-3-aldehydebenzoate;Methyl ester 3-formyl-2-nitro-Benzoate;Methyl 3-formyl-2-nitrobenzoate(For export only)
- CBNumber:
- CB02534693
- Molecular Formula:
- C9H7NO5
- Molecular Weight:
- 209.16
- MDL Number:
- MFCD14706049
- MOL File:
- 138229-59-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl 3-formyl-2-nitrobenzoate 99% | OR55158 | 1g | $33 |
| Methyl 3-formyl-2-nitrobenzoate 99% | OR55158 | 5g | $157 |
| Methyl 3-formyl-2-nitrobenzoate 95% | AA0018AB | 1g | $6 |
| Methyl 3-formyl-2-nitrobenzoate 95% | AA0018AB | 5g | $12 |
| Methyl 3-formyl-2-nitrobenzoate 95% | AA0018AB | 25g | $30 |
| More product size | |||
| Boiling point | 354℃ |
|---|---|
| Density | 1.386 |
| Flash point | 173℃ |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | lumpy powder |
| color | White |
| InChI | InChI=1S/C9H7NO5/c1-15-9(12)7-4-2-3-6(5-11)8(7)10(13)14/h2-5H,1H3 |
| InChIKey | NSLOBVGASZUPDO-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=CC(C=O)=C1[N+]([O-])=O |
| CAS DataBase Reference | 138229-59-1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335-H412 |
| Precautionary statements | P280-P301+P312-P261 |
| HS Code | 2918300090 |
Methyl 3-formyl-2-nitrobenzoate price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR55158 | Methyl 3-formyl-2-nitrobenzoate 99% | 138229-59-1 | 1g | $33 | 2026-06-04 | Buy |
| Apolloscientific | OR55158 | Methyl 3-formyl-2-nitrobenzoate 99% | 138229-59-1 | 5g | $157 | 2026-06-04 | Buy |
| aablocks | AA0018AB | Methyl 3-formyl-2-nitrobenzoate 95% | 138229-59-1 | 1g | $6 | 2026-05-28 | Buy |
| aablocks | AA0018AB | Methyl 3-formyl-2-nitrobenzoate 95% | 138229-59-1 | 5g | $12 | 2026-05-28 | Buy |
| aablocks | AA0018AB | Methyl 3-formyl-2-nitrobenzoate 95% | 138229-59-1 | 25g | $30 | 2026-05-28 | Buy |
Methyl 3-formyl-2-nitrobenzoate Chemical Properties,Uses,Production
Description
Methyl 3-formyl-2-nitrobenzoate is a phase transfer catalyst used to synthesize chlorinated hydrocarbons from inorganic chloride. It is soluble in organic solvents and can synthesize hydrochloric acid, sodium chloride, and zinc chloride. Methyl 3-formyl-2-nitrobenzoate is also used as a catalyst for producing polychlorinated biphenyls. It is hydrolyzed by water to release methyl 3-hydroxy-2-nitrobenzoate.
Uses
Methyl 3-Formyl-2-nitrobenzoate is a reagent used in the synthesis of PARP inhibitors. Intermediate of Niraparib (N481400), a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.
Synthesis
132874-06-7
138229-59-1
Step C: Synthesis of methyl 3-formyl-2-nitrobenzoate; N-methylmorpholine oxide (NMO, 6.10 g, 52.07 mmol) was added to a solution of acetonitrile (150 mL) containing methyl 3-(bromomethyl)-2-nitrobenzoate (7.13 g, 26.023 mmol) and 4A molecular sieves (35.32 g) under nitrogen protection. The reaction mixture was stirred at room temperature for 1.5 hours. Subsequently, the reaction mixture was diluted with ethyl acetate (600 mL) and the insoluble material was removed by vacuum filtration. The filtrate was washed sequentially with water (100 mL), 1N HCl (100 mL) and brine (150 mL) and then dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was purified by fast column chromatography on silica gel, using ethyl acetate/hexane (1:3) as eluent to afford methyl 3-formyl-2-nitrobenzoate as an off-white solid (4.04 g, 74% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 3.95 (s, 3H), 7.77 (t, 1H), 8.18 (dd, 1H), 8.28 (dd, 1H), 9.98 (s, 1H).
References
[1] Patent: WO2005/66136, 2005, A1. Location in patent: Page/Page column 88-89
[2] Patent: WO2009/87381, 2009, A1. Location in patent: Page/Page column 35-36
[3] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7170 - 7185
[4] Organic Process Research and Development, 2011, vol. 15, # 4, p. 831 - 840
[5] Patent: WO2007/113596, 2007, A1. Location in patent: Page/Page column 77
Methyl 3-formyl-2-nitrobenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou Qiwei Pharmatech Co.,Ltd | 13282840061 | mw@qwpharmatech.com | China | 109 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1002 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29626 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1796 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32998 | 60 |
| Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 340 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
View Lastest Price from Methyl 3-formyl-2-nitrobenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-08-11 | Methyl 3-formyl-2-nitrobenzoate
138229-59-1
|
$5.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-08 | Methyl 3-formyl-2-nitrobenzoate
138229-59-1
|
99.0%min | 200kg | Hangzhou ICH Biofarm Co., Ltd | |||
 |
2026-06-30 | Methyl 3-formyl-2-nitrobenzoate
138229-59-1
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Methyl 3-formyl-2-nitrobenzoate
138229-59-1
- $5.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Methyl 3-formyl-2-nitrobenzoate
138229-59-1
- 99.0%min
- Hangzhou ICH Biofarm Co., Ltd
-
- Methyl 3-formyl-2-nitrobenzoate
138229-59-1
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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