4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one
- CAS No.
- 301693-50-5
- Chemical Name:
- 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one
- Synonyms
- Polmacoxib Impurity;Polmacoxib Impurity 1;Calcium acetate Impurity 4;4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-on;4-(3-Fluorophenyl)-2,2-dimethyl-5-[4-(methylthio)phenyl]-3(2H)-furanone;4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one;2,2-dimethyl-4-(3-fluorophenyl)-5-[4-(methylthio)phenyl]-3(2H)-furanone;3(2H)-Furanone, 4-(3-fluorophenyl)-2,2-dimethyl-5-[4-(methylthio)phenyl]-;4-(3-fluorophenyl)-2,2-dimethyl-5- (4-(methylthio)phenyl)furan-3(2H)-one (FFM);4-(3-fluorophenyl)-2,2-diMethyl-5-[4-(Methylsulfanyl)phenyl]-2,3-dihydrofuran-3-one
- CBNumber:
- CB02535892
- Molecular Formula:
- C19H17FO2S
- Molecular Weight:
- 328.4
- MDL Number:
- MFCD22570932
- MOL File:
- 301693-50-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one | 298385 | 250.00mg | $34 |
| 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one | 298385 | 1.00g | $71 |
| 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one | 298385 | 5.00g | $234 |
| 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one 98% | F59383 | 250mg | $100 |
| 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one 98% | F59383 | 1g | $190 |
| Boiling point | 448.2±45.0 °C(Predicted) |
|---|---|
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| InChI | InChI=1S/C19H17FO2S/c1-19(2)18(21)16(13-5-4-6-14(20)11-13)17(22-19)12-7-9-15(23-3)10-8-12/h4-11H,1-3H3 |
| InChIKey | OTXGJFNQTZTDPD-UHFFFAOYSA-N |
| SMILES | O1C(C2=CC=C(SC)C=C2)=C(C2=CC=CC(F)=C2)C(=O)C1(C)C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 298385 | 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one | 301693-50-5 | 250.00mg | $34 | 2026-05-19 | Buy |
| Matrix Scientific | 298385 | 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one | 301693-50-5 | 1.00g | $71 | 2026-05-19 | Buy |
| Matrix Scientific | 298385 | 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one | 301693-50-5 | 5.00g | $234 | 2026-05-19 | Buy |
| Synthonix | F59383 | 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one 98% | 301693-50-5 | 250mg | $100 | 2026-05-06 | Buy |
| Synthonix | F59383 | 4-(3-Fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one 98% | 301693-50-5 | 1g | $190 | 2026-05-06 | Buy |
4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one Chemical Properties,Uses,Production
Synthesis
20769-85-1
301699-27-4
301693-50-5
The general procedure for the synthesis of 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one from 2-bromoisobutyryl bromide and 2-(3-fluorophenyl)-1-(4-(methylthio)phenyl)ethanone was as follows: 2.60 g (10 mmol) of 2-(3-fluorophenyl)-1-(4-(methylthio)phenyl)ethanone was mixed with a 20.8 mL of N,N-dimethylacetamide was stirred and cooled to 0 °C. 2.0 g (50 mmol) of 60% sodium hydride was slowly added at 0 to 5°C and kept at this temperature and stirred for 1.0 hour. 1.38 g (20 mmol) of 1,2,4-triazole was dissolved in 13.8 mL of N,N-dimethylacetamide, then 2.29 g (10 mmol) of 2-bromoisobutyryl bromide was added dropwise, and the mixture was stirred for 2 hr. at about 30 °C. After completion of the reaction, the insoluble material was removed by filtration. The filtrate was slowly dripped into the reaction flask, taking about 1.0 hour. The mixture was stirred overnight at room temperature. Subsequently, 60 mL of 2N hydrochloric acid was added and the mixture was concentrated to near dryness. To the residue, 60 mL of water was added, filtered, and the filter cake was washed twice with water and finally recrystallized from ethanol to give 2.85 g of the target product in 86.8% yield.
References
[1] Patent: CN106866558, 2017, A. Location in patent: Paragraph 0102; 0103; 0104
[2] Bioorganic and Medicinal Chemistry, 2002, vol. 10, # 4, p. 1137 - 1142
4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9897 | 58 |
| Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50108 | 58 | |
| Suzhou ARTK Medchem Co., Ltd. | +86-18168183658 | sales1@artkmedchem.com | China | 39007 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40048 | 58 |
View Lastest Price from 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one
301693-50-5
|
$2.00 | 1KG | 98% | 1kg, 5kg ,50kg | Career Henan Chemical Co |
-
- 4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one
301693-50-5
- $2.00
- 98%
- Career Henan Chemical Co
301693-50-5(4-(3-fluorophenyl)-2,2-dimethyl-5-(4-(methylthio)phenyl)furan-3(2H)-one)Related Search:
1of2
