GYY 4137 Morpholine salt
- CAS No.
- 106740-09-4
- Chemical Name:
- GYY 4137 Morpholine salt
- Synonyms
- ZYJ1122;GYY 4137;ZYJ 1122;ZYJ-1122.;GYY 4137, H2S donor;GYY 4137 MORPHOLINE SALT;GYY4137;GYY-4137;GYY 4137;Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate;4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt;morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate
- CBNumber:
- CB02538277
- Molecular Formula:
- C15H25N2O3PS2
- Molecular Weight:
- 376.474361
- MDL Number:
- MFCD18428020
- MOL File:
- 106740-09-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GYY4137 Dichloromethane complex ≥98% (HPLC) | SML0100 | 10 mg | $89 |
| GYY4137 Dichloromethane complex ≥98% (HPLC) | SML0100 | 50 mg | $362 |
| GYY 4137 ≥95% | 13345 | 10mg | $68 |
| GYY 4137 ≥95% | 13345 | 25mg | $154 |
| GYY 4137 ≥95% | 13345 | 50mg | $258 |
| Melting point | 164-166℃ |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMF: 20 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 3 mg/ml |
| form | White solid. |
| color | White |
| InChI | InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2 |
| InChIKey | YZMHNNLDUWRZFW-UHFFFAOYSA-N |
| SMILES | C1C(OC)=CC=C(P([S-])(N2CCOCC2)=S)C=1.C1C[N+]([H])([H])CCO1 |
| FDA UNII | UDZ9ARY4YG |
| UNSPSC Code | 12352200 |
| NACRES | NA.25 |
GYY 4137 Morpholine salt price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0100 | GYY4137 Dichloromethane complex ≥98% (HPLC) | 106740-09-4 | 10 mg | $89 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0100 | GYY4137 Dichloromethane complex ≥98% (HPLC) | 106740-09-4 | 50 mg | $362 | 2026-04-30 | Buy |
| Cayman Chemical | 13345 | GYY 4137 ≥95% | 106740-09-4 | 10mg | $68 | 2026-04-30 | Buy |
| Cayman Chemical | 13345 | GYY 4137 ≥95% | 106740-09-4 | 25mg | $154 | 2026-04-30 | Buy |
| Cayman Chemical | 13345 | GYY 4137 ≥95% | 106740-09-4 | 50mg | $258 | 2026-04-30 | Buy |
GYY 4137 Morpholine salt Chemical Properties,Uses,Production
Description
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-
Uses
Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.[Cayman Chemical]
Uses
GYY 4137 is a slow releasing hydrogen sulfide donor.
in vivo
GYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner[2].
In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA[3].
GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression[4].
GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease[5].
| Animal Model: | Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells)[2] |
| Dosage: | 100, 200 and 300 mg/kg |
| Administration: | I.p.; daily for 14 days |
| Result: | Reduced tumor volume by 52.5% and 55.3% in HL-60 and MV4–11 injected animals. |
IC 50
Stat-3
storage
+4°C
References
[1] LING LI. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.[J]. Circulation, 2008, 117 18: 2351-2360. DOI: 10.1161/circulationaha.107.753467
[2] LING LI . GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat[J]. Free Radical Biology and Medicine, 2009, 47 1: Pages 103-113. DOI: 10.1016/j.freeradbiomed.2009.04.014
[3] PETER J ELLIOTT Wolf H B Thomas Matthias Zollner. Proteasome inhibition: a new anti-inflammatory strategy.[J]. Journal of Molecular Medicine-Jmm, 2003, 81 4: 235-245. DOI: 10.1007/s00109-003-0422-2
GYY 4137 Morpholine salt Preparation Products And Raw materials
Raw materials
Preparation Products
GYY 4137 Morpholine salt Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1059@dideu.com | China | 29096 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49709 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +86-18051384581 | sales@chemhifuture.com | China | 3123 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +86-571-86217390; +8618058761490 | info@gihichemicals.com | China | 49859 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +86-15355479329 | market18@leapchem.com | China | 43303 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
View Lastest Price from GYY 4137 Morpholine salt manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | GYY4137
106740-09-4
|
$35.00-92.00 | 99.98% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-10 | (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium
106740-09-4
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- GYY4137
106740-09-4
- $35.00-92.00
- 99.98%
- TargetMol Chemicals Inc.
-
- (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium
106740-09-4
- $9.80
- ≥98%
- Career Henan Chemical Co
