Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine Structure
N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine structure
CAS No.
1063733-41-4
Chemical Name:
N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine
Synonyms
N-(2,4-DiMethoxybenzyl)-1,2,4-thiadiazol-5-aMine;(2,4-Dimethoxy-benzyl)-[1,2,4]thiadiazol-5-yl-amine;N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine;1,2,4-Thiadiazol-5-amine, N-[(2,4-dimethoxyphenyl)methyl]-
CBNumber:
CB02599151
Molecular Formula:
C11H13N3O2S
Molecular Weight:
251.3
MDL Number:
MFCD20784227
MOL File:
1063733-41-4.mol
Last updated:2026-09-12 18:48:01
Request For Quotation

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine Properties

storage temp. Keep in dark place,Inert atmosphere,Room temperature
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Signal word  Warning
Hazard statements  H302+H312+H332-H319-H315-H335
Precautionary statements  P280-P261-P304-P340-P312-P301-P330-P305-P351-P338
HS Code  2922390090

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth NSB73341 N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 1063733-41-4 2g $900 2026-06-04 Buy
Biosynth NSB73341 N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 1063733-41-4 1g $900 2026-06-04 Buy
Biosynth NSB73341 N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 1063733-41-4 0.5g $900 2026-06-04 Buy
Biosynth NSB73341 N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 1063733-41-4 0.25g $900 2026-06-04 Buy
Biosynth NSB73341 N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 1063733-41-4 0.1g $900 2026-06-04 Buy
Product number Packaging Price Buy
NSB73341 2g $900 Buy
NSB73341 1g $900 Buy
NSB73341 0.5g $900 Buy
NSB73341 0.25g $900 Buy
NSB73341 0.1g $900 Buy

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine Chemical Properties, Uses, Production

Synthesis

5-Amino-1,2,4-thiadiazole

7552-07-0

2,4-Dimethoxybenzaldehyde

613-45-6

N-[(2,4-DIMETHOXYPHENYL)METHYL]-1,2,4-THIADIAZOL-5-AMINE

1063733-41-4

The reaction was carried out with 5-amino-1,2,4-thiadiazole (3.3 g, 32.6 mmol) and 2,4-dimethoxybenzaldehyde (5.96 g, 35.9 mmol) in toluene (99 mL) under reflux for 2 hours in a Dean-Stark apparatus. After completion of the reaction, it was cooled to room temperature (about 25 °C) and concentrated under reduced pressure to give the imine intermediate. The intermediate was dissolved in methanol (82 mL) and cooled to 0 °C. Subsequently, NaBH4 (1.85 g, 48.9 mmol) was added in batches, after addition, and stirred at room temperature for 18 hours. At the end of the reaction, the reaction mixture was concentrated under reduced pressure, diluted with water (100 mL) and extracted with ethyl acetate (100 mL). The organic layer was separated and the aqueous layer was back-extracted with ethyl acetate (2 x 150 mL). All organic layers were combined and concentrated under reduced pressure, and the resulting crude product was purified by normal phase chromatography (20-66% ethyl acetate/hexane, 220g ISCO column) to afford the target compounds, N-(2,4-dimethoxybenzyl)-1,2,4-thiadiazol-5-amine (1-3), as a white solid (5.9 g, 72% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 12, p. 2683 - 2688
[2] Patent: WO2012/4714, 2012, A2. Location in patent: Page/Page column 57-58
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 17, p. 7818 - 7839
[4] Patent: US2012/10182, 2012, A1. Location in patent: Page/Page column 35
[5] Patent: WO2012/4706, 2012, A2. Location in patent: Page/Page column 75

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine Preparation Products And Raw materials

Raw materials

5-Amino-1,2,4-thiadiazole 2,4-Dimethoxybenzaldehyde Sodium triacetoxyborohydride Sodium borohydride Toluene
Methanol

1of2

Preparation Products

3-cyano-N-(2,4-dimethoxybenzyl)-4-fluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine Suppliers

Global Suppliers ( 26)
Supplier Tel Email Country ProdList Advantage
Shanghai Chainpharm Bio-medical Technology Co., Ltd. +86-021-61727342 13611721451 sales@chainpharm.com China 984 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3698 58
JW & Y Pharmlab Co., Ltd. 021-64340559 xinyu_shi@jwypharmlab.com.cn China 11999 58
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Capot Chemical Co.,Ltd. +86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Aikon International Limited 025-58859352 15955137747 sales01@aikonchem.com China 16021 58
Shanghai WangFa Chemical Technology Co., Ltd. 13918479294 xiebenfa@163.com China 4354 58
Shanghai zhigan biotechnology co., LTD zhiqianbio@126.com China 19765 58
Hefei TNJ Chemical Industry Co.,Ltd. +86-0551-65418684 +86-18949823763 sales@tnjchem.com China 25333 58
Labnetwork lnc. +86-27-50766799 +86-18062016861 contact@labnetwork.com China 19981 58
Supplier Advantage
Shanghai Chainpharm Bio-medical Technology Co., Ltd. 58
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
JW & Y Pharmlab Co., Ltd. 58
Wuxi AppTec 58
Capot Chemical Co.,Ltd. 60
Aikon International Limited 58
Shanghai WangFa Chemical Technology Co., Ltd. 58
Shanghai zhigan biotechnology co., LTD 58
Hefei TNJ Chemical Industry Co.,Ltd. 58
Labnetwork lnc. 58

N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine Spectrum

N-[(2,4-DIMETHOXYPHENYL)METHYL]-1,2,4-THIADIAZOL-5-AMINE(1063733-41-4)1HNMR

1063733-41-4 (N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine) Related Search:

tert-Butyl 4-fluoro-2-formylphenylcarbamate N-Pyridin-3-ylethane-1,2-diamine N-(2-Formylphenyl)-4-methyl-benzenesulf& Deionized water N-(4-Phenyl-cyclohex-1-enyl)-formamide
N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine

1of2

(2,4-Dimethoxy-benzyl)-[1,2,4]thiadiazol-5-yl-amine 1,2,4-Thiadiazol-5-amine, N-[(2,4-dimethoxyphenyl)methyl]- N-(2,4-DiMethoxybenzyl)-1,2,4-thiadiazol-5-aMine N-[(2,4-Dimethoxyphenyl)methyl]-1,2,4-thiadiazol-5-amine 1063733-41-4