acetyl Methanesulfonate
- CAS No.
- 5539-53-7
- Chemical Name:
- acetyl Methanesulfonate
- Synonyms
- NSC 158252;Busulfan Impurity 6;Busulfan Impurity 10;Methanesulfonyl acetate;acetyl Methanesulfonate;Acetic acid, anhydride with methanesulfonic acid
- CBNumber:
- CB02610946
- Molecular Formula:
- C3H6O4S
- Molecular Weight:
- 138.14
- MDL Number:
- MOL File:
- 5539-53-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
acetyl Methanesulfonate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 440847 | Acetyl Methanesulfonate | 5539-53-7 | 1g | $509 | 2026-06-03 | Buy |
| Usbiological | 440847 | Acetyl Methanesulfonate | 5539-53-7 | 5g | $885 | 2026-06-03 | Buy |
| Biosynth | FAA53953 | Methanesulfonyl acetate | 5539-53-7 | 0.5g | $472 | 2026-06-04 | Buy |
| Biosynth | FAA53953 | Methanesulfonyl acetate | 5539-53-7 | 5g | $1829 | 2026-06-04 | Buy |
| aablocks | AA00DMHM | methanesulfonyl acetate 95% | 5539-53-7 | 100mg | $140 | 2026-05-28 | Buy |
acetyl Methanesulfonate Chemical Properties, Uses, Production
Uses
Acetyl Methanesulfonate, is an impurity of Busulfan (B689900), an alkylating agent with antileukemic activity. Antineoplastic. It is a reagent for ether cleavage, for the cleavage of activated cyclopropanes as partial structures of cyclopropyl ketones, and for acetylation of aromatic rings.
Preparation
Preparative Methods: Acetyl Methanesulfonate can be prepared on a large scale (1 mol) from Acetyl Chloride and Methanesulfonic Acid by heating at reflux followed by fractional distillation (85% yield).
storage
Handling, Storage, and Precautions: slightly hygroscopic. However, no particular precautions are required upon exposure to air for a short period of time. acetyl Methanesulfonate is stable if stored at 4 °C for several months. Use in a fume hood.
Purification Methods
The main impurity is methanesulfonic acid. Reflux it with redistilled acetyl chloride for 6-10hours, i.e. until no further HCl is absorbed in a trap, and exclude moisture. Distil off excess of AcCl and carefully distil it below 0.001mm with the bath temperature below 120o to give the anhydride as a pale yellow oil which solidifies below 0o. Below ~130o it gives the disulfonic anhydride, and above ~130o polymers are formed, and it is used for cleaving ethers [Preparation, IR, NMR: Karger & Mazur J Org Chem 36 528, 532 1971]. [Beilstein 2 H 166, 2 III 349.]
acetyl Methanesulfonate Preparation Products And Raw materials
Raw materials
Preparation Products
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