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3-b]pyridine

3-b]pyridine Structure
3-b]pyridine structure
CAS No.
1357945-27-7
Chemical Name:
3-b]pyridine
Synonyms
o[4,3-b]pyridine;oro-3-iodo-1H-pyrazoL;5-chloro-3-iodo-1H-pyrazolo[4;5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine;1H-Pyrazolo[4,3-b]pyridine, 5-chloro-3-iodo-
CBNumber:
CB02616504
Molecular Formula:
C6H3ClIN3
Molecular Weight:
279.47
MDL Number:
MFCD16658104
MOL File:
1357945-27-7.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:44
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3-b]pyridine Properties

Boiling point 404.9±40.0 °C(Predicted)
Density 2.284±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 7.79±0.40(Predicted)
Appearance Light yellow to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

3-b]pyridine price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC C366890 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 1357945-27-7 5g $1100 2021-12-16 Buy
Matrix Scientific 189033 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 1357945-27-7 5g $2296 2021-12-16 Buy
Matrix Scientific 189033 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 1357945-27-7 500mg $526 2021-12-16 Buy
Matrix Scientific 189033 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 1357945-27-7 1g $766 2021-12-16 Buy
Crysdot CD11279631 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine 95+% 1357945-27-7 5g $776 2021-12-16 Buy
Product number Packaging Price Buy
C366890 5g $1100 Buy
189033 5g $2296 Buy
189033 500mg $526 Buy
189033 1g $766 Buy
CD11279631 5g $776 Buy

3-b]pyridine Chemical Properties,Uses,Production

Uses

5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine is a reactant used for the synthesis of Benzothiazol-6-ylacetic acid derivatives as anti-HIV.

Synthesis

5-Chloro-1H-pyrazolo[4,3-b]pyridine

94220-45-8

3-b]pyridine

1357945-27-7

To a solution of 5-chloro-1H-pyrazolo[4,3-b]pyridine (XIII) (13 g, 84.7 mmol) in N,N-dimethylformamide (DMF) (100 mL) was added iodine (43.0 g, 169 mmol), followed by batchwise addition of potassium hydroxide powder (23.75 g, 423 mmol), and the reaction mixture was cooled in an ice water bath. The reaction mixture was stirred at 25 °C overnight. The solid potassium hydroxide was removed by filtration and the filter cake was washed with ethyl acetate (EtOAc). Most of the DMF was evaporated under reduced pressure and the residue was diluted with water (200 mL) and extracted with ethyl acetate (5 × 200 mL). The organic phases were combined, washed with saturated saline (500 mL) and dried over anhydrous sodium sulfate (Na2SO4). The organic phases were concentrated to afford 5-chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine (XIV) as an orange solid (23.5 g, 84.1 mmol, 99.3% yield). The m/z of C6H3ClIN3 was measured to be 279.9 ([M+H]+) by electrospray ionization mass spectrometry (ESIMS).

References

[1] Patent: WO2017/23989, 2017, A1. Location in patent: Paragraph 0606; 0607
[2] Patent: WO2017/23972, 2017, A1. Location in patent: Paragraph 0606; 0607
[3] Patent: WO2017/24015, 2017, A1. Location in patent: Paragraph 006
[4] Patent: WO2017/23988, 2017, A1. Location in patent: Paragraph 0607
[5] Patent: WO2017/220431, 2017, A1. Location in patent: Page/Page column 36; 37

3-b]pyridine synthesis

94220-45-8
1357945-27-7
Synthesis of 3-b]pyridine from 5-Chloro-1H-pyrazolo[4,3-b]pyridine

3-b]pyridine Preparation Products And Raw materials

Raw materials

3-Amino-6-chloro-2-picoline 5-Chloro-1H-pyrazolo[4,3-b]pyridine 5-CHLORO-1H-PYRAZOLO[3,4-C]PYRIDINE N-Iodosuccinimide iodine
Potassium hydroxide N,N-Dimethylformamide

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Preparation Products

3-b]pyridine Suppliers

Global( 58)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29852 58
Accela ChemBio Inc. 		+1-858-6993322 info@accelachem.com United States 21193 58
Shandong chuangyingchemical Co., Ltd. 		18853181302 sale@chuangyingchem.com CHINA 5906 58
Xuzhou B&C Chemical Co.,Ltd 		+86-400-0516-021 +8615300872630 info@bcpharma.com China 2732 58
Zhengzhou Anbu Chem Co.,Ltd 		+86-0371-88006763; +8615988602810 sales@anbuchem.com China 3000 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20185 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39927 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Accela ChemBio Inc. 		58
Shandong chuangyingchemical Co., Ltd. 		58
Xuzhou B&C Chemical Co.,Ltd 		58
Zhengzhou Anbu Chem Co.,Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Aladdin Scientific 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from 3-b]pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-b]pyridine pictures 2019-07-06 3-b]pyridine
1357945-27-7
 US $1.00 / KG 1KG 95% 500kg Career Henan Chemical Co
  • 3-b]pyridine pictures
  • 3-b]pyridine
    1357945-27-7
  • US $1.00 / KG
  • 95%
  • Career Henan Chemical Co

3-b]pyridine Spectrum

3-b]pyridine(1357945-27-7)1HNMR

1357945-27-7(3-b]pyridine)Related Search:

Vitamin B series
5-chloro-3-iodo-1H-pyrazolo[4 5-Chloro-3-iodo-1H-pyrazolo[4,3-b]pyridine o[4,3-b]pyridine oro-3-iodo-1H-pyrazoL 1H-Pyrazolo[4,3-b]pyridine, 5-chloro-3-iodo- 1357945-27-7