5-Chloro-1H-pyrazolo[4,3-b]pyridine
![5-Chloro-1H-pyrazolo[4,3-b]pyridine Structure](CAS/GIF/94220-45-8.gif)
- CAS No.
- 94220-45-8
- Chemical Name:
- 5-Chloro-1H-pyrazolo[4,3-b]pyridine
- Synonyms
- 5-chloro-2H-pyrazolo[4,3-b]pyridine;5-chloro-1H-pyrazolo[4;5-Chloro-1H-pyrazolo[4,3-...;5-CHLORO-1H-PYRAZOLO[4,3-B]PYRIDINE;1H-Pyrazolo[4,3-b]pyridine,5-chloro-;5-Chloro-1H-pyrazolo[4,3-b]pyridine
- CBNumber:
- CB4770800
- Molecular Formula:
- C6H4ClN3
- Molecular Weight:
- 153.57
- MDL Number:
- MFCD05663984
- MOL File:
- 94220-45-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 323.8±22.0 °C(Predicted) |
|---|---|
| Density | 1.531±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | 9.74±0.40(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | 1S/C6H4ClN3/c7-6-2-1-4-5(9-6)3-8-10-4/h1-3H,(H,8,10) |
| InChIKey | PYZUYYOYVZFJGX-UHFFFAOYSA-N |
| SMILES | Clc1ccc2[nH]ncc2n1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
5-Chloro-1H-pyrazolo[4,3-b]pyridine price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | BLN00012 | 5-Chloro-1H-pyrazolo[4,3-b]pyridine Aldrich | 94220-45-8 | 1g | $834 | 2026-04-30 | Buy |
| Usbiological | 435980 | 5-Chloro-1H-pyrazolo[4,3-b]pyridine | 94220-45-8 | 10mg | $319 | 2026-06-03 | Buy |
| Usbiological | 435980 | 5-Chloro-1H-pyrazolo[4,3-b]pyridine | 94220-45-8 | 50mg | $425 | 2026-06-03 | Buy |
| Usbiological | 269928 | 5-Chloro-1H-pyrazolo[4,3-b]pyridine Asreported | 94220-45-8 | 50mg | $353 | 2026-06-03 | Buy |
| Usbiological | 269928 | 5-Chloro-1H-pyrazolo[4,3-b]pyridine Asreported | 94220-45-8 | 100mg | $488 | 2026-06-03 | Buy |
5-Chloro-1H-pyrazolo[4,3-b]pyridine Chemical Properties, Uses, Production
Uses
5-Chloro-1H-pyrazolo[4,3-b]pyridine is an intermediate used to prepare 2-aryl or heteroaryl indole derivatives as ASIC channel modulators for treating pain, bone diseases, and other disorders.
Synthesis
164666-68-6
![5-Chloro-1H-pyrazolo[4,3-b]pyridine](/CAS/GIF/94220-45-8.gif)
94220-45-8
6-Chloro-2-methylpyridin-3-amine (12.8 g, 0.09 mol) was used as starting material and dissolved in chloroform (500 mL). Acetic anhydride (34.0 mL, 0.36 mol) and potassium acetate (10.6 g, 0.11 mol) were added sequentially, and the reaction mixture was stirred and reacted at 60 °C for 2 hours. Subsequently, isoamyl nitrite (27.8 mL, 0.21 mol) and 1,4,7,10,13,16-hexaoxacyclooctadecane (2.4 g, 8.90 mmol) were added to the reaction system, and the reaction continued to be stirred at 60 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the resulting crude product was dissolved in a solvent mixture of methanol (225 mL) and water (50 mL), cooled to 0 °C and potassium carbonate (45 g) was added in batches. The mixture was stirred at 0 °C for 10 min, then brought to room temperature and continued stirring for 3 h. The mixture was then cooled to room temperature and stirred for 3 h. The reaction solution was then mixed with potassium carbonate. Water was added to the reaction solution and stirred at room temperature for 1 h. The precipitate was collected and washed with cold water and hexane. The resulting solid was dried in a vacuum oven at 50 °C overnight to afford the target product 5-chloro-1H-pyrazolo[3,4-b]pyridine (13.6 g, 97% yield) as a white solid.LRMS (m/z): 154,156 ([M+H]+, [M+3]+).1H-NMR (300 MHz, CDCl3)δ: 7.35 (d, 1H), 7.84 (dd, 1H), 8.26 (d, 1H), 10.39 (s, 1H).
References
[1] Patent: WO2017/220431, 2017, A1. Location in patent: Page/Page column 35
[2] Patent: CN108003161, 2018, A. Location in patent: Paragraph 0745; 0747-0749
5-Chloro-1H-pyrazolo[4,3-b]pyridine Preparation Products And Raw materials
Raw materials
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Preparation Products
5-Chloro-1H-pyrazolo[4,3-b]pyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| ZEROSCHEM.CO.,LTD. | 10-61256048 13810278579; | sales@zeroschem.com | China | 1400 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Wuhan Target Pharm Co.,Ltd | 0086-27-81360461 | hustzsy@hotmail.com | China | 52 | 58 |
View Latest Price from 5-Chloro-1H-pyrazolo[4,3-b]pyridine manufacturers
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![5-Chloro-1H-pyrazolo[4,3-b]pyridine pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/c921d7a1-64c0-4068-acde-e4c2008c0c11.png) |
2020-01-08 | 5-Chloro-1H-pyrazolo[4,3-b]pyridine
94220-45-8
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 5-Chloro-1H-pyrazolo[4,3-b]pyridine
94220-45-8
- $1.00
- 99.0%
- Career Henan Chemical Co
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