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DL-4-Chlorophenylalanine

DL-4-Chlorophenylalanine structure

CAS No.: 7424-00-2

Chemical Name:: DL-4-Chlorophenylalanine

Synonyms: PCP;P-CHLOROPHENYLALANINE;4-CHLORO-DL-PHENYLALANINE;Fenclonine;2-amino-3-(4-chlorophenyl)propanoic acid;H-DL-PHE(4-CL)-OH;2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID;OI13;c-pal;PCOLC

CBNumber:: CB0261841

Molecular Formula:: C9H10ClNO2

Molecular Weight:: 199.63

MDL Number:: MFCD00002601

MOL File:: 7424-00-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-27 17:33:43

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DL-4-Chlorophenylalanine Properties

Melting point	>240 °C (dec.)(lit.)
Boiling point	339.5±32.0 °C(Predicted)
Density	1.2409 (rough estimate)
refractive index	1.5790 (estimate)
storage temp.	room temp
solubility	Aqueous Acid (Slightly), Methanol (Slightly)
pka	pK1: 2.08(+1);pK2: 8.96(0) (25°C)
form	Powder
color	White to almost white
Water Solubility	slightly soluble
BRN	2805758
InChI	1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChIKey	NIGWMJHCCYYCSF-UHFFFAOYSA-N
SMILES	NC(Cc1ccc(Cl)cc1)C(O)=O
CAS DataBase Reference	7424-00-2(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	R5J7E3L9SP
EPA Substance Registry System	4-Chlorophenylalanine (7424-00-2)
UNSPSC Code	12352209
NACRES	NA.32

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H317

Precautionary statements

P280-P301+P310+P330-P302+P352

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-43

Safety Statements

36/37-45

RIDADR

UN 2811 6.1/PG 3

WGK Germany

RTECS

AY4390010

TSCA

TSCA listed

HS Code

29224985

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Skin Sens. 1

Hazardous Substances Data

7424-00-2(Hazardous Substances Data)

NFPA 704

	0
1		0

DL-4-Chlorophenylalanine price More Price(63)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C6506	4-Chloro-DL-phenylalanine	7424-00-2	5g	$163	2026-04-30	Buy
Sigma-Aldrich	C6506	4-Chloro-DL-phenylalanine	7424-00-2	25g	$603	2026-04-30	Buy
TCI Chemical	C0253	4-Chloro-DL-phenylalanine >98.0%(T)	7424-00-2	1g	$22	2026-04-30	Buy
TCI Chemical	C0253	4-Chloro-DL-phenylalanine >98.0%(T)	7424-00-2	25g	$290	2026-04-30	Buy
Cayman Chemical	26168	p-chloro Phenylalanine ≥98%	7424-00-2	5g	$44	2026-04-30	Buy

Product number	Packaging	Price	Buy
C6506	5g	$163	Buy
C6506	25g	$603	Buy
C0253	1g	$22	Buy
C0253	25g	$290	Buy
26168	5g	$44	Buy

DL-4-Chlorophenylalanine Chemical Properties, Uses, Production

Chemical Properties

Crystalline

Uses

An irreversible tryptophan hydroxylase inhibitor.

Uses

4-Chloro-DL-phenylalanine is an irreversible tryptophan hydroxylase inhibitor that depletes serotonin in the brain.

Uses

4-Chloro-DL-phenylalanine has been used:

as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras⁺ male zebrafish
to induce insomnia in rat models
used to treat embryos to examine its effect on serotonin
for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
to feed flies to explore serotonin effect

Definition

ChEBI: 2-amino-3-(4-chlorophenyl)propanoic acid is a phenylalanine derivative.

Biological Activity

4-Chloro-DL-phenylalanine (Fenclonine, PCPA, CP-10188) is a selective and irreversible inhibitor of tryptophan hydroxylase, a rate-limiting enzyme in the biosynthesis of serotonin (5-HYDROXYTRYPTAMINE). 4-Chloro-DL-phenylalanine acts pharmacologically to deplete endogenous levels of serotonin.

Biochem/physiol Actions

4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.

Safety Profile

An experimental teratogen. When heated to decomposition it emits toxic fumes of NOx and Cl-.

in vivo

4-Chloro-DL-phenylalanine(PCPA) markedly attenuates MCT(monocrotaline)-induced pulmonary vascular remodeling and lung inflammation, inhibits the expression of Tph-1 and SERT and suppresses the expression of MMP-2/-9, TIMP-1/-2, interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule-1 (ICAM-1). PCPA inhibits 5-HT by suppressing Tph-1, regulating SERT and the serotonin downstream signaling pathway.

storage

Room temperature

DL-4-Chlorophenylalanine synthesis

Synthesis of DL-4-Chlorophenylalanine from 4-Chlorobenzyl chloride

DL-4-Chlorophenylalanine Preparation Products And Raw materials

Raw materials

Glycine, N-[(4-chlorophenyl)methylene]-, ethyl ester Propanedioic acid,2-(acetylamino)-2-[(4-chlorophenyl)methyl]-, 1,3-diethyl ester L-4-Chlorophenylalanine DL-4-Chlorophenylalanine ethyl ester hydrochloride 4-Chlorocinnamic acid

4-Chlorobenzyl chloride 4-Chlorobenzyl bromide 4-Chlorobenzaldehyde

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Preparation Products

4-Chlorophenethylamine

DL-4-Chlorophenylalanine Suppliers

Global Suppliers ( 299)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Shanghai HC Biotech Co., Ltd	021-20227858	sale@hcbiotech.com.cn	China	1173	55
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Shanghai HC Biotech Co., Ltd	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Beijing Ouhe Technology Co., Ltd	60
Pure Chemistry Scientific Inc.	62

View Latest Price from DL-4-Chlorophenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-22	Fenclonine 7424-00-2	$42.00		99.90%	10g	TargetMol Chemicals Inc.
2026-04-22	Fenclonine 7424-00-2	$42.00		99.90%	10g	TargetMol Chemicals Inc.
2021-08-12	DL-4-Chlorophenylalanine 7424-00-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

Fenclonine
7424-00-2
$42.00
99.90%
TargetMol Chemicals Inc.

Fenclonine
7424-00-2
$42.00
99.90%
TargetMol Chemicals Inc.

DL-4-Chlorophenylalanine
7424-00-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

DL-4-Chlorophenylalanine Spectrum

DL-4-Chlorophenylalanine(7424-00-2)MS DL-4-Chlorophenylalanine(7424-00-2)¹HNMR DL-4-Chlorophenylalanine(7424-00-2)IR1 DL-4-Chlorophenylalanine(7424-00-2)Raman

7424-00-2 (DL-4-Chlorophenylalanine) Related Search:

DL-Penicillamine DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY,DL-4-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE,DL-P-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE 2-Amino-3-(3-methoxy-phenyl)-propionic acid 2-Fluoro-DL-phenylalanine 2-Amino-3-(2-chloro-phenyl)-propionic acid

4-Bromo-DL-phenylalanine DL-3-(4-Fluorophenyl)alanine 2-Bromo-DL-Phenylalanine DL-4-Cyanophenylalanine 4-Iodo-DL-phenylalanine

3-(3-Hydroxyphenyl)-DL-alanine L-4-Chlorophenylalanine DL-4-Chlorophenylalanine ethyl ester hydrochloride Fmoc-2-chloro-DL-phenylalanine Z-DL-Phe(4-Cl)-OH

3-(4-Chloro-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid Fmoc-3-chloro-DL-phenylalanine 2-tert-Butoxycarbonylamino-3-(4-chloro-phenyl)-propionic acid

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(±)-3-(4-Chlorophenyl)-2-aminopropanoic acid NSC-77370 DL-4-Chloro-phe-OH DL-Phe(4-Cl)-OH 4-Chloro-DL-Phenylalanine H-4-Chloro-DL-Phe-OH, (RS)-2-AMino-3-(4-chloro-phenyl)-propionic acid, Fenclonine, PCPA 4-Chloro-DL-phenylalanine, 98+% DL-4-Chlorophenylalanine, 98+%, 98+% DL-2-Amino-3-(4-chloro-phenyl)-propionic acid 4-Chloro-DL-phenylalanine (PCPA) Fenchlonine(PCPA) 2-AMINO-3-(4-CHLOROPHENYL)PROPIONIC ACID 4-CHLOROPHENYLALANINE DL-4-CHLOROPHENYLALANINE DL-P-CHLOROPHENYLALANINE fenclonin (RS)-2-Amino-3-(4-chlorophenyl)propionic acid 4-Chloro-DL-phenylalanine≥ 99% (HPLC) (+/-)-P-CHLOROPHENYLALANINE, (P-CPA) CAU SES DEPLETION OF S DL-P-CHLOROPHENYLALANINE CRYSTALLINE 4-Chloro-Dl-Phenylalanine,>99% 2-amino-3-(4-chlorophenyl)propanoic acid 3-(4-CHLOROPHENYL)ALANINE,DL- DL-Phe(4-Cl)-OH 3-(4-Chlorophenyl)-DL-alanine DL-4-Chlorophenylalanine, 98+% PCP, PCPA (2R)-2-Azaniumyl-3-(4-chlorophenyl)propanoate Alanine, 3-(p-chlorophenyl)- 3-(p-chlorophenyl)-DL-alanine P-chloro benzoic acetate (2S)-2-ammonio-3-(4-chlorophenyl)propanoate (+-)-p-chlorphenylalanine cp10,188 c-pal LABOTEST-BB LT00453604 H-P-CHLORO-DL-PHE-OH TIMTEC-BB SBB003551 PCP P-CHLOROPHENYLALANINE P-CHLORO-DL-PHENYLALANINE fenchlonine 4-Chloro-DL-phenylalanine > Chloro DL Phenylalanine, 4-chloro- -4-ChL DL-4-Chlorophenylalanine USP/EP/BP p-Chlorophenylalanin Fenclonine (PCPA 4-Chloro-DL-phenylalanine, ≥ 98.0% Contezolid Impurity 9 Fenclonine, 10 mM in DMSO 4-Chloro-DL-phenylalanine OI13 PCOLC C6506-5G 4-Chloro-DL-phenylalanine[C6506] 4-CHLORO-DL-PHENYLALANINE Fenclonine