4-Chlorocinnamic acid
- CAS No.
- 1615-02-7
- Chemical Name:
- 4-Chlorocinnamic acid
- Synonyms
- P-CHLOROCINNAMIC ACID;ARBA-033;AKOS 92736;orocinnamic acid;4-Chlorociamic acid;TIMTEC-BB SBB008203;RARECHEM BK HC T318;4-Chlorocinmic acid;p-chloro-cinnamicaci;4-CHLOROCINNAMIC ACID
- CBNumber:
- CB1114188
- Molecular Formula:
- C9H7ClO2
- Molecular Weight:
- 182.6
- MDL Number:
- MFCD00004396
- MOL File:
- 1615-02-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 248-250 °C(lit.) |
|---|---|
| Boiling point | 260.71°C (rough estimate) |
| Density | 1.2377 (rough estimate) |
| refractive index | 1.5426 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| pka | 4.41(at 25℃) |
| form | Fine Crystalline Powder |
| color | White |
| BRN | 1365308 |
| InChI | InChI=1S/C9H7ClO2/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6H,(H,11,12) |
| InChIKey | GXLIFJYFGMHYDY-ZZXKWVIFSA-N |
| SMILES | C(O)(=O)C=CC1=CC=C(Cl)C=C1 |
| CAS DataBase Reference | 1615-02-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NIST Chemistry Reference | p-Chlorocinnamic acid(1615-02-7) |
| EPA Substance Registry System | 2-Propenoic acid, 3-(4-chlorophenyl)- (1615-02-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H302 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P270-P280-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38-20/21/22 | |||||||||
| Safety Statements | 36-28A-26-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GD8490000 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4-Chlorocinnamic acid price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C31600 | 4-Chlorocinnamic acid 99% | 1615-02-7 | 25g | $91.9 | 2026-04-30 | Buy |
| TCI Chemical | C0149 | 4-Chlorocinnamic Acid >98.0%(T) | 1615-02-7 | 25g | $66 | 2026-04-30 | Buy |
| TCI Chemical | C0149 | 4-Chlorocinnamic Acid >98.0%(T) | 1615-02-7 | 500g | $411 | 2023-06-20 | Buy |
| Usbiological | 269326 | 4-Chlorocinnamic acid Asreported | 1615-02-7 | 100g | $402 | 2026-06-03 | Buy |
| Usbiological | 269326 | 4-Chlorocinnamic acid Asreported | 1615-02-7 | 250g | $566 | 2026-06-03 | Buy |
4-Chlorocinnamic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
4-Chlorocinnamic Acid is a derivative of Cinnamic Acid (C442030) and plays an important role in the development of plants. 4-Chlorocinnamic Acid may also show potential antimicrobial, antioxidant, anti-inflammatory, and antitumoral activity.
Definition
ChEBI: 4-chlorocinnamic acid is an organochlorine compound comprising trans-cinnamic acid having a chloro substituent at the 4-position on the phenyl ring. It is functionally related to a trans-cinnamic acid.
Synthesis
To a 100mL three-necked round-bottomed flask, 1.41g (0.01mol) of p-chlorobenzaldehyde, 1.27g (0.011mol) of malonic acid, and 0.77g (0.01mol) of ammonium acetate were added and mixed well. A thermometer and a spherical condenser tube were connected and the reaction was carried out in a microwave reactor. After the reaction was completed, 5 mL of water was heated into the flask and the unreacted p-chlorobenzaldehyde was removed by distillation with water vapor. Add 10% sodium hydroxide solution 5mL to 6mL, add activated carbon to remove the color, extract filtration, transfer the filtrate to a beaker, acidify with concentrated hydrochloric acid until the Congo red paper turns blue or pH = 3 to 4. Cool to precipitate the crystals, extract filtration, wash the precipitate with a small amount of water, extract dry, and dry the crude product. Recrystallize with water-ethanol (1:3 v/v) and dry. The yield was calculated, and the optimal synthesis conditions were: material ratio of n(p-chlorobenzaldehyde):n(malonic acid):n(ammonium acetate) = 1.0:1.1:1.0, reaction time of 13 min, power of 800 W, and a yield of 85.8% under these conditions. Melting point determination and infrared spectral analysis were carried out. Compared with the traditional method, it has the advantages of short time, high yield and less pollution.
Purification Methods
Recrystallise the acid from EtOH or aqueous EtOH (charcoal). UV has max at 275nm (EtOH). [Walling & Wolfstirn J Am Chem Soc 69 852 1947, Beilstein 9 H 596, 9 II 395, 9 III 2727, 9 IV 2033.]
4-Chlorocinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zaoyang Cixiang Pharmaceutical Technology Co., LTD | 0710-15671321689 15671321689 | info@cixiangyy.com | China | 28 | 58 |
| Wuhan lenmaike Industrial Co., Ltd. | 027-83916065 18627177625 | 3561583191@qq.com | China | 48 | 58 |
| Zaoyang cixiang medical technology co. LTD | 15996000437 15971080675 | 385091169@qq.com | China | 43 | 58 |
| Zaoyang Cixiang Medical Technology Co., Ltd | 19871689299 | 1242417277@qq.com | China | 52 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Lastest Price from 4-Chlorocinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4-Chlorocinnamic acid
1615-02-7
|
$1.20-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | 4-Chlorocinnamic Acid
1615-02-7
|
$10.00 | 1KG | 99.8% | 100tons | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-05-11 | 4-Chlorocinnamic acid
1615-02-7
|
10g | TargetMol Chemicals Inc. |
-
- 4-Chlorocinnamic acid
1615-02-7
- $1.20-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4-Chlorocinnamic Acid
1615-02-7
- $10.00
- 99.8%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 4-Chlorocinnamic acid
1615-02-7
- $0.00
- TargetMol Chemicals Inc.
