3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester
- CAS No.
- 76240-19-2
- Chemical Name:
- 3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester
- Synonyms
- Ethyl 4-ethoxy-2-oxobut-3-enoate;3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester
- CBNumber:
- CB02624543
- Molecular Formula:
- C8H12O4
- Molecular Weight:
- 172.18
- MDL Number:
- MFCD11045806
- MOL File:
- 76240-19-2.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BDA24019 | Ethyl 4-ethoxy-2-oxobut-3-enoate | 76240-19-2 | 0.5g | $550 | 2026-06-04 | Buy |
| Biosynth | BDA24019 | Ethyl 4-ethoxy-2-oxobut-3-enoate | 76240-19-2 | 1g | $756.25 | 2026-06-04 | Buy |
| aablocks | AA00G6XR | Ethyl 4-ethoxy-2-oxobut-3-enoate 95% | 76240-19-2 | 50mg | $249 | 2026-05-28 | Buy |
| aablocks | AA00G6XR | Ethyl 4-ethoxy-2-oxobut-3-enoate 95% | 76240-19-2 | 100mg | $278 | 2026-05-28 | Buy |
| aablocks | AA00G6XR | Ethyl 4-ethoxy-2-oxobut-3-enoate 95% | 76240-19-2 | 250mg | $310 | 2026-05-28 | Buy |
3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester Chemical Properties, Uses, Production
Synthesis
4755-77-5
109-92-2
76240-19-2
To a three-necked round-bottomed flask equipped with a magnetic stirrer was added 1,4-dioxane (6.8 mL), triethylamine (2.96 g, 0.0293 mol) and ethyl vinyl ether (7.37 g, 0.102 mol). The reaction mixture was slowly heated to 30 °C under nitrogen protection. Ethyl chlorooxyacetate (2.73 g, 0.02 mol) was added dropwise over a period of 5 minutes using a syringe, followed by stirring the reaction system for 2 hours while maintaining the reaction system at 33-36°C. After completion of the reaction, the mixture was cooled to room temperature and insoluble solids were removed by filtration. The crude product obtained by concentrating the filtrate was dissolved in water (15 mL) and extracted with ethyl acetate (15 mL). The organic layers were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 4-ethoxy-2-oxo-3-butenoate as a light brown oil (3.02 g, 87.8% yield). The product was characterized by 1H NMR (CDCl3): δ 7.86 (d, 1H, J = 12.6 Hz), 6.17 (d, 1H, J = 12.6 Hz), 4.30 (q, 2H, J = 7.1 Hz), 4.05 (q, 2H, J = 7.1 Hz), 1.36 (m, 6H).
References
[1] Patent: WO2004/111011, 2004, A2. Location in patent: Page 27; 2
[2] European Journal of Organic Chemistry, 2013, # 19, p. 4131 - 4145
[3] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 96 - 116
[4] Patent: WO2009/123714, 2009, A2. Location in patent: Page/Page column 52
[5] Patent: WO2012/73138, 2012, A1. Location in patent: Page/Page column 68
3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
3-Butenoic acid, 4-ethoxy-2-oxo-, ethyl ester Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
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