Methyl Pyrazole-3-carboxylate
- CAS No.
- 15366-34-4
- Chemical Name:
- Methyl Pyrazole-3-carboxylate
- Synonyms
- METHYL 1H-PYRAZOLE-3-CARBOXYLATE;METHYL 1H-PYRAZOLE-5-CARBOXYLATE;1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER;Albb-003661;methyl 1H-pyrazole-;TIMTEC-BB SBB000006;3- pyrazole carboxylate;Methyl 3-Pyrazolecarboxylate;Methyl Pyrazole-3-carboxylate;MethylPyrazole-3-carboxylate>
- CBNumber:
- CB6714824
- Molecular Formula:
- C5H6N2O2
- Molecular Weight:
- 126.11
- MDL Number:
- MFCD00649381
- MOL File:
- 15366-34-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 141-142℃ |
|---|---|
| Boiling point | 271℃ |
| Density | 1.275 |
| Flash point | 118℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in methanol. |
| pka | 11.04±0.10(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| λmax | 217nm(EtOH)(lit.) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 22 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2933119000 | |||||||||
| NFPA 704 |
|
Methyl Pyrazole-3-carboxylate price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS009495 | Methyl 1H-pyrazole-3-carboxylate AldrichCPR | 100 mg | $179 | 2025-07-31 | Buy | |
| Sigma-Aldrich | CDS009495 | Methyl 1H-pyrazole-3-carboxylate AldrichCPR | 15366-34-4 | 100MG | $174 | 2024-03-01 | Buy |
| TCI Chemical | M2444 | Methyl Pyrazole-3-carboxylate >98.0%(GC) | 15366-34-4 | 1g | $38 | 2026-04-30 | Buy |
| Apolloscientific | OR110467 | Methyl 1H-pyrazole-3-carboxylate 98% | 15366-34-4 | 10g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR110467 | Methyl 1H-pyrazole-3-carboxylate 98% | 15366-34-4 | 25g | $30 | 2026-06-04 | Buy |
Methyl Pyrazole-3-carboxylate Chemical Properties, Uses, Production
Uses
The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550), Methyl Pyrazole-3-carboxylate can be used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.
Uses
The methyl ester derivative of 4-Pyrazolecarboxylic Acid (P842550) used in the preparation of androgen receptor (AR) antagonists as well as pyrazole nucleosides.
Synthesis
67-56-1
1621-91-6
15366-34-4
To a stirred solution of 1H-pyrazole-3-carboxylic acid (2 g, 17.8 mmol, 1 eq.) in methanol (20 mL) was slowly added thionyl chloride (2.5 mL, 35.5 mmol, 2 eq.). The reaction mixture was stirred at 40 °C for 5 hours. Upon completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The resulting residue was dissolved in dichloromethane (DCM) and washed with saturated aqueous sodium bicarbonate (NaHCO3). The organic layer was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate=1/3, v/v) to afford methyl 1H-pyrazole-3-carboxylate (1.8 g, yield 79.6%) as a white solid.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 1, p. 159 - 166
[2] Russian Journal of General Chemistry, 2011, vol. 81, # 8, p. 1745 - 1746
[3] Patent: WO2018/11628, 2018, A1. Location in patent: Paragraph 00314
[4] Heterocycles, 1996, vol. 42, # 2, p. 517 - 523
[5] Journal fuer Praktische Chemie (Leipzig), 1935, vol. <2> 143, p. 259,273
Methyl Pyrazole-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui CONO Fine Chemical Co., Ltd. | 0550-0550-7097550 15051613561 | sales@ahknchem.com | China | 221 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Yangzhou Siyu Chemical Co.,Ltd. | 0514-87325867 | sales@siyuchem.com | China | 370 | 55 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from Methyl Pyrazole-3-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Methyl Pyrazole-3-carboxylate
15366-34-4
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2022-02-09 | Methyl 1H-pyrazole-5-carboxylate
15366-34-4
|
1KG | 99.5% | 100 tons | Honest Joy Holdings Limited | ||
 |
2019-07-06 | METHYL 1H-PYRAZOLE-3-CARBOXYLATE
15366-34-4
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- Methyl Pyrazole-3-carboxylate
15366-34-4
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
-
- Methyl 1H-pyrazole-5-carboxylate
15366-34-4
- $0.00
- 99.5%
- Honest Joy Holdings Limited
-
- METHYL 1H-PYRAZOLE-3-CARBOXYLATE
15366-34-4
- $1.00
- 95%
- Career Henan Chemical Co
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