5-Nitrovanillin
- CAS No.
- 6635-20-7
- Chemical Name:
- 5-Nitrovanillin
- Synonyms
- 4-HYDROXY-3-METHOXY-5-NITROBENZALDEHYDE;5-Nitro;AKOS B029013;AURORA 13227;5-NitrovaniL;5-Nitrovanilin;ASISCHEM R40895;5-Nitrovaniline;5-NITROVANILLIN;5-Nitrovanilline
- CBNumber:
- CB0281908
- Molecular Formula:
- C8H7NO5
- Molecular Weight:
- 197.14
- MDL Number:
- MFCD00007118
- MOL File:
- 6635-20-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Nitrovanillin 97% | N28000 | 25g | $53.7 |
| 5-Nitrovanillin >98.0%(T) | H0728 | 5g | $22 |
| 5-Nitrovanillin >98.0%(T) | H0728 | 10g | $36 |
| 5-Nitrovanillin | 284970 | 100g | $337 |
| 5-Nitrovanillin | 284970 | 250g | $475 |
| More product size | |||
| Melting point | 172-175 °C (lit.) |
|---|---|
| Boiling point | 334.23°C (rough estimate) |
| Density | 1.5023 (rough estimate) |
| vapor pressure | 0.001Pa at 25℃ |
| refractive index | 1.5700 (estimate) |
| Flash point | 97℃ |
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 2.1g/L in organic solvents at 20 ℃ |
| form | powder to crystal |
| pka | 4.97±0.38(Predicted) |
| color | Yellow to Brown to Dark green |
| Water Solubility | 700mg/L at 23℃ |
| Sensitive | Air Sensitive |
| BRN | 1973746 |
| InChI | 1S/C8H7NO5/c1-14-7-3-5(4-10)2-6(8(7)11)9(12)13/h2-4,11H,1H3 |
| InChIKey | ZEHYRTJBFMZHCY-UHFFFAOYSA-N |
| SMILES | [H]C(=O)c1cc(OC)c(O)c(c1)[N+]([O-])=O |
| LogP | 0.301 at 23℃ |
| CAS DataBase Reference | 6635-20-7(CAS DataBase Reference) |
| FDA UNII | G6SQ47R9WB |
| EPA Substance Registry System | 5-Nitrovanillin (6635-20-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29130000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
5-Nitrovanillin price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N28000 | 5-Nitrovanillin 97% | 6635-20-7 | 25g | $53.7 | 2026-04-30 | Buy |
| TCI Chemical | H0728 | 5-Nitrovanillin >98.0%(T) | 6635-20-7 | 5g | $22 | 2026-04-30 | Buy |
| TCI Chemical | H0728 | 5-Nitrovanillin >98.0%(T) | 6635-20-7 | 10g | $36 | 2026-04-30 | Buy |
| Usbiological | 284970 | 5-Nitrovanillin | 6635-20-7 | 100g | $337 | 2026-06-03 | Buy |
| Usbiological | 284970 | 5-Nitrovanillin | 6635-20-7 | 250g | $475 | 2026-06-03 | Buy |
5-Nitrovanillin Chemical Properties,Uses,Production
Chemical Properties
yellow-green fine crystalline powder
Uses
5-Nitrovanillin is a reagent used in the synthesis of feruloyl and caffeoyl which have antitumor properties.
Definition
ChEBI: A member of the class of benzaldehydes that is vanillin in which the hydrogen ortho- to the hydroxy group is substituted by a nitro group.
Flammability and Explosibility
Non flammable
Synthesis
121-33-5
6635-20-7
The general procedure for the synthesis of 5-nitrovanillin from vanillin was as follows: vanillin (94 mg, 1 mmol) was dissolved in 3 mL of glacial acetic acid in a 50 mL test tube. Solid Y(NO3)3-6H2O (383 mg, 1 mmol) was then added and the reaction mixture was shaken continuously for 10 min at room temperature. The reaction process was monitored by thin layer chromatography (TLC) in petroleum ether with 10% ethyl acetate. Upon completion of the reaction, 30 mL of ice-cold water was added to the reaction mixture and allowed to stand for 15 min. The solid product formed was collected by filtration and washed with cold water. The solid product obtained was used directly for analysis without further purification. The experimental methods for synthesizing compounds 2a-2e are detailed in Supporting Information.
Purification Methods
It forms yellow plates from AcOH and needles from EtOH [Slotta & Szyszke Chem Ber 68 184 1935]. With diazomethane, 5-nitro-3,4-dimethoxyacetophenone is formed [Brady & Manjunath J Chem Soc 125 1067 1924]. The methyl ether crystallises from EtOAc or AcOH, m 88o, 90-91o, and the phenylhydrazone has m 108-110o (from aqueous EtOH). [Finger & Schott J Prakt Chem [2] 115 288 1927.] The oxime has m 216o (from EtOH or AcOH), and the oxime acetate has m 147o (from aqueous EtOH) [Vogel Monatsh Chem 20 384 1899, Brady & Dunn J Chem Soc 107 1861 1915]. [Beilstein 8 III 2064.]
References
[1] Journal of Physical Organic Chemistry, 2000, vol. 13, # 9, p. 511 - 517
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 8, p. 3396 - 3411
[3] Tetrahedron Letters, 2006, vol. 47, # 15, p. 2507 - 2509
[4] Synthetic Communications, 2008, vol. 38, # 11, p. 1745 - 1752
[5] Tetrahedron, 1992, vol. 48, # 10, p. 1895 - 1910
5-Nitrovanillin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10403 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3971 | 58 |
| Nantong Haigine Pharma Technology Co., Ltd | 0086-513-86266699 | CHINA | 156 | 58 | |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2251 | 58 |
View Lastest Price from 5-Nitrovanillin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-28 | 5-Nitrovanillin
6635-20-7
|
$75.00-100.00 | 1kg | 99% | 5000Ton | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2025-05-26 | 5-Nitrovanillin
6635-20-7
|
$3.00 | 1kg | 0.99 | 10000 | Hebei Fengjia New Material Co., Ltd | |
 |
2021-08-12 | 5-Nitrovanillin
6635-20-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Nitrovanillin
6635-20-7
- $75.00-100.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- 5-Nitrovanillin
6635-20-7
- $3.00
- 0.99
- Hebei Fengjia New Material Co., Ltd
-
- 5-Nitrovanillin
6635-20-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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