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Boc-D-4,4'-biphenylalanine

Boc-D-4,4'-biphenylalanine structure

CAS No.: 128779-47-5

Chemical Name:: Boc-D-4,4'-biphenylalanine

Synonyms: (R)-3-([1,1'-Biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid;BOC-D-4;impurity 43;BOC-D-BPH-OH;BOC-D-BIP-OH;-BIPHENYLALANINE;BOC-D-BIP(4,4')-OH;SACUBITRIL(LCZ696);BOC-D-4,4'-BIPHE-OH;LCZ-696 Impurity 80

CBNumber:: CB0285209

Molecular Formula:: C20H23NO4

Molecular Weight:: 341.4

MDL Number:: MFCD00191185

MOL File:: 128779-47-5.mol

MSDS File:: SDS

Last updated:2026-09-12 18:48:05

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Boc-D-4,4'-biphenylalanine Properties

Boiling point	528.2±50.0 °C(Predicted)
Density	1.161±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.88±0.10(Predicted)
Appearance	White to off-white Solid
CAS DataBase Reference	128779-47-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

Hazard Codes

HS Code

2922498590

NFPA 704

	1
0		0

Boc-D-4,4'-biphenylalanine price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	264927	Boc-p-phenyl-D-Phenylalanine Asreported	128779-47-5	1g	$353	2026-06-03	Buy
Usbiological	264927	Boc-p-phenyl-D-Phenylalanine Asreported	128779-47-5	2g	$488	2026-06-03	Buy
Usbiological	264927	Boc-p-phenyl-D-Phenylalanine Asreported	128779-47-5	5g	$837	2026-06-03	Buy
Usbiological	264927	Boc-p-phenyl-D-Phenylalanine Asreported	128779-47-5	10g	$1177	2026-06-03	Buy
Usbiological	264927	Boc-p-phenyl-D-Phenylalanine Asreported	128779-47-5	25g	$1677	2026-06-03	Buy

Product number	Packaging	Price	Buy
264927	1g	$353	Buy
264927	2g	$488	Buy
264927	5g	$837	Buy
264927	10g	$1177	Buy
264927	25g	$1677	Buy

Boc-D-4,4'-biphenylalanine Chemical Properties, Uses, Production

Uses

Boc-D-4,4'-biphenylalanine is used as a reagent in the synthesis of pyrrolopyrimidine inhibitors of Akt as antitumor agents. Boc-D-4,4'-biphenylalanine is also used in the preparation of (-)-Bestatin-based inhibitors.

Synthesis

24424-99-5

155760-02-4

3-BIPHENYL-4-YL-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID

119273-61-9

To a mixed solution of tetrahydrofuran (THF) (80 mL) and water (80 mL) of (S)-3-([1,1'-biphenyl]-4-yl)-2-aminopropanoic acid (25) (5 g, 20.72 mmol) was added di-tert-butyl dicarbonate (BOC2O) (5.77 mL, 24.87 mmol) and sodium hydroxide (NaOH) (1.077 g. 26.9 mmol). The reaction mixture was stirred at room temperature for 6 hours before being cooled to 0 °C and the pH was adjusted to about 6-7 by slowly adding 1.5 N aqueous hydrochloric acid (HCl) to quench the reaction. Subsequently, the reaction mixture was extracted with ethyl acetate (EtOAc) (3 x 50 mL). The combined organic layers were washed sequentially with brine (50 mL) and water (50 mL), dried over anhydrous sodium sulfate and concentrated to give the crude product as a colloidal off-white solid. The crude product was purified by washing with petroleum ether (PE) with 10% ethyl acetate (4 x 20 mL). The resulting white solid was filtered and dried under vacuum to afford (S)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propionic acid (26) (6.5 g, 19.04 mmol, 92% yield). The product was analyzed by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI) to confirm the structure.1H NMR data: δ 7.67-7.62 (m, 2H), 7.58 (d, J=8.5 Hz, 2H), 7.50-7.43 (m, 2H), 7.39-7.31 (m, 3H), 7.10 (d, J=8.0 Hz. 1H), 4.17-4.07 (m, 1H), 3.07 (dd, J=13.6,4.5Hz, 1H), 2.88 (dd, J=13.6,10.0Hz, 1H), 1.37-1.23 (m, 9H). Mass spectral data: 340.2 ([M-1]-).

References

[1] Tetrahedron Letters, 2018, p. 4267 - 4271

Boc-D-4,4'-biphenylalanine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate N-Boc-4-broMo-L-phenylalanine Methyl ester Phenylboronic acid L-4,4'-Biphenylalanine Sodium hydroxide

Tetrahydrofuran Water

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Preparation Products

sacubitril (2S,4S)-Sacubitril-O-isobutane LCZ696 InteMediate [1,?1'-?Biphenyl]?-?4-?pentanoic acid, γ-?[[4-?(1,?1-?dimethylethoxy)?-?1,?4-?dioxobutyl]?amino]?-?α-?methyl-?, ethyl ester, [S-?(R*,?S*)?]?- (9CI)

Boc-D-4,4'-biphenylalanine Suppliers

Global Suppliers ( 158)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai HC Biotech Co., Ltd	021-20227858	sale@hcbiotech.com.cn	China	1173	55
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Suzhou haiyu Biochem Industrial Co., LTD	512-68097639 18013585858	744942877@qq.com	China	915	62
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Jiangsu Vcare PharmaTech Co., Ltd.	025-58741518 13327700685	sales@vcarepharmatech.com	China	281	61

Supplier	Advantage
Shanghai HC Biotech Co., Ltd	55
Alfa Aesar	84
Energy Chemical	61
Capot Chemical Co., Ltd	66
Suzhou haiyu Biochem Industrial Co., LTD	62
Adamas Reagent, Ltd.	59
Accela ChemBio Co.,Ltd.	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Jiangsu Vcare PharmaTech Co., Ltd.	61

View Latest Price from Boc-D-4,4'-biphenylalanine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-08-12	BOC-D-4,4"-BIPHENYLALANINE 128779-47-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	BOC-D-4,4'-BIPHENYLALANINE 128779-47-5	$7.00	1kg	99%	100kg	Career Henan Chemical Co
2019-07-06	BOC-D-4,4'-BIPHENYLALANINE 128779-47-5	$7.00	1KG	99%	100kg	Career Henan Chemical Co

BOC-D-4,4"-BIPHENYLALANINE
128779-47-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

BOC-D-4,4'-BIPHENYLALANINE
128779-47-5
$7.00
99%
Career Henan Chemical Co

BOC-D-4,4'-BIPHENYLALANINE
128779-47-5
$7.00
99%
Career Henan Chemical Co

Boc-D-4,4'-biphenylalanine Spectrum

BOC-D-4,4'-BIPHENYLALANINE(128779-47-5)¹HNMR

128779-47-5 (Boc-D-4,4'-biphenylalanine) Related Search:

Valsartan Impurity 61 Valsartan Impurity 3 Valsartan Ethyl Ester USAWIVMZUYOXCF-UHFFFAOYSA-N Isoleucine Valsartan

Valsartan Desvaleryl Impurity Valsartan n-Propyl 4-(2-Cyanophenyl)benzyl alcohol [1,1'-Biphenyl]-4-pentanoic acid, γ-amino-α-methyl-, ethyl ester, (Hydrochloride)(1:1), (αS,γS)- Valsartan Impurity 1

(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate Valsartan Impurity 32 LCZ-696 Impurity 60 Telmisartan Impurity 10 1426129-50-1 enantioMer

(R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester N-Nitroso-di-iso-propylamine

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BOC-D-PHE(4-PHENYL)-OH BOC-D-BPH-OH BOC-D-BIP(4,4')-OH BOC-D-BIP-OH BOC-D-ALA(4,4'-BIPHENYL)-OH BOC-3-(4-BIPHENYLYL)-D-ALANINE BOC-4-PHENYL-D-PHENYLALANINE BOC-4-PHENYL-D-PHE-OH BOC-4-BIPHENYL-D-ALA BOC-BETA-(4-BIPHENYLYL)-D-ALA-OH BOC-P-PHENYL-D-PHE-OH BOC-(R)-2-AMINO-3-(1,1'-BIPHENY-4-YL)PROPANOIC ACID D-TBOC-P-BIPHENYLALANINE (R)-3-BIPHENYL-4-YL-2-TERT-BUTOXYCARBONYLAMINO-PROPIONIC ACID Boc-D-4-Phenylphenylalanine N-ALPHA-T-BUTOXYCARBONYL-D-4,4'-BIPHENYLALANINE N-ALPHA-T-BUTOXYCARBONYL-D-(4-PHENYL)PHENYLALANINE (R)-N-ALPHA-TERT-BUTYLOXYCARBONYL-BIPHENYLALANINE N-Boc-3-(4-biphenylyl)-D-alanine, 95% (2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid (2R)-3-(Biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propionic acid, tert-Butyl [(1R)-2-(biphenyl-4-yl)-1-carboxyethyl]carbamate (R)-a-(Boc-amino)-biphenyl-4-propanoic acid N-Boc-3-(4-biphenylyl)-D-alani (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoic acid Boc-p-phenyl-D-Phenylalanine≥ 99% (HPLC) 4-Phenyl-D-phenylalanine, N-BOC protected (R)-3-(biphenyl-4-yl)-2-(tert-butoxycarbonylamino)propanoic acid (R)-N-ALPHA-T-BUTYLOXYCARBONYL-BIPHENYLALANINE 3-(4-Biphenylyl)-N-(tert-butoxycarbonyl)-D-alanine REF DUPL: Boc-D-4,4'-Biphenylalanine (S)-2-AMino-3-(4'-((S)-2-(tert-butoxycarbonylaMino)-2-carboxyethyl)biphenyl-4-yl)propanoic acid Boc-b-(4-biphenylyl)-D-Ala-OH, Boc-D-Bip-OH BOC-D-4,4'-BIPHE-OH [1,1'-Biphenyl]-4-propanoic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, (αR)- (Tert-Butoxy)Carbonyl D-4,4'-Biphenylalanine (R)-3-([1,1\'-biphenyl]-4-yl)-2-aminopropanoic acid hydrochloride Sacubitril Impurity 55 SACUBITRIL(LCZ696) -BIPHENYLALANINE (2R)-3-{[1,1'-biphenyl]-4-yl}-2-{[(tert-butoxy)carbonyl]amino}propanoic acid impurity 43 N-Boc-3-(4-biphenylyl)-D-alanine,95% (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(4-phenylphenyl)propanoicaci BOC-D-4,4'-BIPHENYLALANINE USP/EP/BP BOC-D-4 LCZ-696 Impurity 80 LCZ696 valsartan + sacubitril impurity 43 N-Boc-3-(4-biphenylyl)-D-alanine (R)-3-([1,1'-Biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid Boc-D-4,4'-biphenylalanine 128779-47-5 C20H23NO4 Phenylalanine analogs and other aromatic alpha amino acids Amino Acids a-amino Biphenyl & Diphenyl ether Amino Acid Derivatives