2,6-Dimethoxybenzoic acid
- CAS No.
- 1466-76-8
- Chemical Name:
- 2,6-Dimethoxybenzoic acid
- Synonyms
- AKOS BBS-00003742;RARECHEM AL BO 1076;2,6-Dimethoxybenzoic;Novobiocin Impurity 4;2,6-dimethoxy-benzoicaci;2,6-DIMETHOXYBENZOIC ACID;Benzoicacid,2,6-dimethoxy-;2,6-DimethoxybenzoicAcid>2,6-Dimethoxybenzoic acid,99%;γ-Resorcylic acid diMethyl ether
- CBNumber:
- CB0303008
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MDL Number:
- MFCD00002437
- MOL File:
- 1466-76-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 185-187 °C (lit.) |
|---|---|
| Boiling point | 275.56°C (rough estimate) |
| Density | 1.2481 (rough estimate) |
| refractive index | 1.4500 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 14.7g/l soluble |
| form | Crystalline Powder |
| pka | pK1:3.44 (25°C) |
| color | White to off-white |
| Water Solubility | 0.35 g/100 mL (25 ºC) |
| BRN | 2212190 |
| InChI | 1S/C9H10O4/c1-12-6-4-3-5-7(13-2)8(6)9(10)11/h3-5H,1-2H3,(H,10,11) |
| InChIKey | MBIZFBDREVRUHY-UHFFFAOYSA-N |
| SMILES | COc1cccc(OC)c1C(O)=O |
| LogP | 0.660 |
| CAS DataBase Reference | 1466-76-8(CAS DataBase Reference) |
| FDA UNII | G6B3P1LO43 |
| NIST Chemistry Reference | Benzoic acid, 2,6-dimethoxy-(1466-76-8) |
| EPA Substance Registry System | Benzoic acid, 2,6-dimethoxy- (1466-76-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DG8598725 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29189010 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
2,6-Dimethoxybenzoic acid price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D131601 | 2,6-Dimethoxybenzoic acid 98% | 1466-76-8 | 25g | $66.9 | 2023-06-20 | Buy |
| TCI Chemical | D1959 | 2,6-Dimethoxybenzoic Acid >98.0%(GC)(T) | 1466-76-8 | 25g | $67 | 2026-04-30 | Buy |
| TCI Chemical | D1959 | 2,6-Dimethoxybenzoic Acid >98.0%(GC)(T) | 1466-76-8 | 250g | $399 | 2023-06-20 | Buy |
| Usbiological | 299802 | 2,6-Dimethoxybenzoic Acid ≥99% | 1466-76-8 | 100mg | $283 | 2026-06-03 | Buy |
| TRC | TRC-D469640-25G | 2,6-Dimethoxybenzoic Acid | 1466-76-8 | 25g | $64 | 2026-06-03 | Buy |
2,6-Dimethoxybenzoic acid Chemical Properties,Uses,Production
Chemical Properties
white to off-white crystalline powder. Hardly soluble in water, soluble in alkali and organic solvents, such as benzene and toluene.
Uses
2,6-Dimethoxybenzoic Acid is used in the synthesis of indoles as well as coumarins related to Novobiocin (N888500), used as potent inhibitors of heat-shock protein 90 in the treatment of breast cancer.
Preparation
2,6-Dimethoxybenzoic acid is the key intermediate in the preparation of gamma-resorcylic acid which has been described as having activity against rheumatic fever.
The Preparation of 2,6-Dimethoxybenzoic Acid
Cite this: J. Org. Chem. 1956, 21, 3, 368–369
Publication Date:March 1, 1956
https://doi.org/10.1021/jo01109a604
Definition
ChEBI: 2,6-Dimethoxybenzoic acid is a member of benzenes and a carbonyl compound. It is a polyphenol compound found in foods of plant origin.
Synthesis Reference(s)
Synthetic Communications, 22, p. 13, 1992 DOI: 10.1080/00397919208021074
Flammability and Explosibility
Not classified
Purification Methods
Crystallise the acid from water or 1,1-dichloroethane (m 187.5-188.5o). [Beilstein 10 H 388, 10 I 185, 10 II 259, 10 III 1401, 10 IV 1456.]
2,6-Dimethoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| YANGZHOU HENGCHUAN CHEMICAL CO., LTD. | 13775575144 | 59033115@qq.com | China | 32 | 58 |
| Shanghai Arbor Chemical Co., Ltd. | 021-60451683 15021268886 | sales@arborchemical.com | China | 765 | 55 |
| Wuhan kamik Technology Co., Ltd | 18162538168 | 201981259@qq.com | China | 7778 | 58 |
| Nanjing Hequan New Materials Technology Co., Ltd. | 18355039361 | 18355039361@163.com | China | 30 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Lastest Price from 2,6-Dimethoxybenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-30 | 2,6-Dimethoxybenzoic acid
1466-76-8
|
1kg | 98 | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 2,6-Dimethoxybenzoic acid
1466-76-8
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 2,6-Dimethoxybenzoic acid
1466-76-8
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2,6-Dimethoxybenzoic acid
1466-76-8
- $0.00
- 98
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,6-Dimethoxybenzoic acid
1466-76-8
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 2,6-Dimethoxybenzoic acid
1466-76-8
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
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