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ChemicalBook >> CAS DataBase List >>10β,17β-dihydroxyestra-1,4-dien-3-one

10β,17β-dihydroxyestra-1,4-dien-3-one

10β,17β-dihydroxyestra-1,4-dien-3-one Structure
10β,17β-dihydroxyestra-1,4-dien-3-one structure
CAS No.
549-02-0
Chemical Name:
10β,17β-dihydroxyestra-1,4-dien-3-one
Synonyms
DHED;10β;4-dien-3-one;17β-dihydroxyestra-1;10β,17β-dihydroxyestra-1,4-dien-3-one;10,17β-Dihydroxy-estra-1,4-dien-3-one;10β,17β-dihydroxyestra-1,4-dien-3-one;10b,17b-Dihydroxy-estra-1,4-dien-3-one;Estra-1,4-dien-3-one, 10,17-dihydroxy-, (17β)-;10β,17β dihydroxyestra 1,4 dien 3 one,10β,17βdihydroxyestra1,4dien3one
CBNumber:
CB03037801
Molecular Formula:
C18H24O3
Molecular Weight:
288.38
MDL Number:
MOL File:
549-02-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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10β,17β-dihydroxyestra-1,4-dien-3-one Properties

Melting point 217-219 °C(Solv: ethyl acetate (141-78-6))
Boiling point 485.3±45.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 10mg/mL, clear
form powder
pka 12.35±0.60(Predicted)
color white to light brown
optical activity [α]/D -20 to -30°, c = 1 in methanol
InChI 1S/C18H24O3/c1-17-8-7-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)6-9-18(11,15)21/h6,9-10,13-16,20-21H,2-5,7-8H2,1H3/t13-,14-,15-,16-,17-,18+/m0/s1
InChIKey UIKDFTLKOKNUJP-UGDFAFBOSA-N
SMILES O[C@@]12C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=CC(C=C1)=O
FDA UNII UR9WW8CA3J
UNSPSC Code 51111800
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Health Hazard (GHS08)
GHS08
Signal word  Danger
Hazard statements  H360Df
Precautionary statements  P201-P280-P308+P313
WGK Germany  WGK 3
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Repr. 1B

10β,17β-dihydroxyestra-1,4-dien-3-one price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1642 DHED ≥98% (HPLC) 549-02-0 5MG $119 2026-04-30 Buy
Sigma-Aldrich SML1642 DHED ≥98% (HPLC) 549-02-0 25MG $480 2026-04-30 Buy
ChemScene CS-0102991 10β,17β-dihydroxyestra-1,4-dien-3-one 99.37% 549-02-0 5mg $87 2026-06-04 Buy
ChemScene CS-0102991 10β,17β-dihydroxyestra-1,4-dien-3-one 99.37% 549-02-0 10mg $162 2026-06-04 Buy
ChemScene CS-0102991 10β,17β-dihydroxyestra-1,4-dien-3-one 99.37% 549-02-0 25mg $357 2026-06-04 Buy
Product number Packaging Price Buy
SML1642 5MG $119 Buy
SML1642 25MG $480 Buy
CS-0102991 5mg $87 Buy
CS-0102991 10mg $162 Buy
CS-0102991 25mg $357 Buy

10β,17β-dihydroxyestra-1,4-dien-3-one Chemical Properties, Uses, Production

Uses

DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′s disease (PD)-like motor syndrome.

Biochem/physiol Actions

DHED is a substrate for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent dehydrogenase/reductase. Its expression in the brain is correlated to neuroprotection functionality.

in vivo

10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), is an inactive bioprecursor prodrug of 17β-estradiol converting to 17β-estradiol only in the brain. DHED as an E2-bioprecursor may be a viable approach for delivering E2 selectively into the brain for the potential treatment of hot flushes[1].

10β,17β-dihydroxyestra-1,4-dien-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

10β,17β-dihydroxyestra-1,4-dien-3-one Suppliers

Global Suppliers ( 23)
Supplier Tel Email Country ProdList Advantage
DONGSHENG CHIRAL PHARMA 15800326364 18051538752 582512789@qq.com China 447 55
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Dideu Industries Group Limited +8617392712697 1022@dideu.com China 29091 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 27626 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Aikon International Limited 025-58859352 18651614124 2881516338@qq.com China 9968 58
Supplier Advantage
DONGSHENG CHIRAL PHARMA 55
Sigma-Aldrich 80
Shanghai YuanYe Biotechnology Co., Ltd. 60
Dideu Industries Group Limited 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
Aikon International Limited 58

View Latest Price from 10β,17β-dihydroxyestra-1,4-dien-3-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
10β,17β-dihydroxyestra-1,4-dien-3-one pictures 2026-07-27 10β,17β-dihydroxyestra-1,4-dien-3-one
549-02-0
 $99.00 10g TargetMol Chemicals Inc.
10β,17β-dihydroxyestra-1,4-dien-3-one pictures 2026-07-27 10β,17β-dihydroxyestra-1,4-dien-3-one
549-02-0
 $99.00 10g TargetMol Chemicals Inc.
10β,17β-dihydroxyestra-1,4-dien-3-one pictures 2026-07-27 10β,17β-dihydroxyestra-1,4-dien-3-one
549-02-0
 $99.00 10g TargetMol Chemicals Inc.

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10β,17β-dihydroxyestra-1,4-dien-3-one Estra-1,4-dien-3-one, 10,17-dihydroxy-, (17β)- 10,17β-Dihydroxy-estra-1,4-dien-3-one 10β 17β-dihydroxyestra-1 4-dien-3-one 10β,17β dihydroxyestra 1,4 dien 3 one,10β,17βdihydroxyestra1,4dien3one 10b,17b-Dihydroxy-estra-1,4-dien-3-one 10β,17β-dihydroxyestra-1,4-dien-3-one DHED 549-02-0