Methyl 2-amino-4-hydroxybenzoate
- CAS No.
- 401568-70-5
- Chemical Name:
- Methyl 2-amino-4-hydroxybenzoate
- Synonyms
- Prucalopride Impurity44;METHYL 2-AMINO-4-HYDROXYBENZOAT;Methyl 2-amino-4-hydroxybenzoate;Prucalopride Succinate iMpurit 44;Benzoic acid, 2-amino-4-hydroxy-, methyl ester;Methyl 2-amino-4-hydroxybenzoate ISO 9001：2015 REACH
- CBNumber:
- CB03066333
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD08274816
- MOL File:
- 401568-70-5.mol
- MSDS File:
- SDS
| Melting point | 154-155 °C |
|---|---|
| Boiling point | 330.6±22.0 °C(Predicted) |
| Density | 1.305±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 8.41±0.18(Predicted) |
| Appearance | Light yellow to light brown Solid |
| CAS DataBase Reference | 401568-70-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H335-H319-H302-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
Methyl 2-amino-4-hydroxybenzoate price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BRA56870 | methyl 2-amino-4-hydroxybenzoate | 401568-70-5 | 2.5g | $413 | 2026-06-04 | Buy |
| Activate Scientific | AS115797 | Methyl 2-amino-4-hydroxybenzoate 98% | 401568-70-5 | 1g | $97 | 2026-06-04 | Buy |
| Activate Scientific | AS115797 | Methyl 2-amino-4-hydroxybenzoate 98% | 401568-70-5 | 5g | $385 | 2026-06-04 | Buy |
| Matrix Scientific | 299593 | Methyl 2-amino-4-hydroxybenzoate | 401568-70-5 | 250.00mg | $69 | 2026-05-19 | Buy |
| Matrix Scientific | 299593 | Methyl 2-amino-4-hydroxybenzoate | 401568-70-5 | 1.00g | $86 | 2026-05-19 | Buy |
Methyl 2-amino-4-hydroxybenzoate Chemical Properties, Uses, Production
Uses
This product is used as an organic and pharmaceutical intermediate.
Synthesis
178758-50-4
401568-70-5
Step 3: Methyl 4-hydroxy-2-nitrobenzoate (4.410 g, 22.369 mmol) was dissolved in methanol (80 mL) under the protection of nitrogen atmosphere and stirred at room temperature. Ammonium formate (5.642 g, 89.475 mmol) and 5% Pd/C catalyst (450 mg) were subsequently added. After the reaction lasted for 5 h, the reaction mixture was filtered through a diatomaceous earth pad and washed well with methanol. The filtrate was concentrated under reduced pressure and the resulting residue was subjected to liquid-liquid partitioning with ethyl acetate (150 mL) and water (40 mL). After vigorous shaking, the organic layer was separated and washed sequentially with water (3 × 30 mL) and saturated saline (2 × 30 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2-amino-4-hydroxybenzoate (3.593 g, 21.494 mmol, 96% yield) as an off-white solid with a melting point of 113-118 °C. The product was separated by 1H NMR (1H NMR, 1H NMR, 1H NMR, 1H NMR). The product was characterized by 1H NMR (DMSO-d6): δ 3.70 (s, 3H), 5.98 (dd, 1H), 6.10 (s, 1H), 6.59 (s, 1H), 7.54 (d, 1H), 9.81 (s, 1H); the mass spectrum [ES(-)] showed m/z 166 ([M-H]-).
References
[1] Patent: US2005/70584, 2005, A1. Location in patent: Page/Page column 24
[2] Journal of the Chemical Society, 1949, p. 1498,1502
Methyl 2-amino-4-hydroxybenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 2-amino-4-hydroxybenzoate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
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| BePharm Ltd | 400-685-9117 | market@bepharm.com | China | 15081 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
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| Aikon International Limited | 025-58859352 19370895928 | sales01@aikonchem.com | China | 15078 | 58 |
| Suzhou Nuoouman Biological Technology Co., Ltd. | 15026866316 | 180642609@qq.com | China | 4966 | 58 |
| SHANGHAI FDC-CHEMICAL CO.,LTD | 021-61469567 13774476675 | sales@fdc-chemical.com | China | 10000 | 58 |
| Shanghai Benso Pharmaceutical Technology Co., Ltd. | 15088289376;13917786310 | 248775804@qq.com | China | 4917 | 58 |
