N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
![N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Structure](CAS/20180629/GIF/383418-30-2.gif)
- CAS No.
- 383418-30-2
- Chemical Name:
- N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- Synonyms
- HPA-12;N-[(2R,4S)-1,4-Dihydroxy-4-phenylbutan-2-yl]dodecanamide;N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide;Dodecanamide, N-[(1R,3S)-3-hydroxy-1-(hydroxymethyl)-3-phenylpropyl]-;N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide
- CBNumber:
- CB03069617
- Molecular Formula:
- C22H37NO3
- Molecular Weight:
- 363.53
- MDL Number:
- MOL File:
- 383418-30-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | Chloroform: soluble; DMSO: soluble |
| form | powder to crystal |
| color | White to Almost white |
| InChI | 1S/C22H37NO3/c1-2-3-4-5-6-7-8-9-13-16-22(26)23-20(18-24)17-21(25)19-14-11-10-12-15-19/h10-12,14-15,20-21,24-25H,2-9,13,16-18H2,1H3,(H,23,26)/t20-,21+/m1/s1 |
| InChIKey | YCAKBKAOFSILDC-RTWAWAEBSA-N |
| SMILES | N([C@@H](CO)C[C@H](O)c1ccccc1)C(=O)CCCCCCCCCCC |
| CAS DataBase Reference | 383418-30-2 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| WGK Germany | WGK 3 |
|---|---|
| HS Code | 2924.29.7790 |
| Storage Class | 11 - Combustible Solids |
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2894 | HPA-12 ≥98% (HPLC) | 383418-30-2 | 5 mg | $263 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2894 | HPA-12 ≥98% (HPLC) | 383418-30-2 | 25 mg | $892.5 | 2026-04-30 | Buy |
| TCI Chemical | H1553 | N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide >98.0%(HPLC) | 383418-30-2 | 5mg | $529 | 2026-04-30 | Buy |
| Cayman Chemical | 28350 | HPA-12 ≥98% | 383418-30-2 | 5mg | $263 | 2026-04-30 | Buy |
| Cayman Chemical | 28350 | HPA-12 ≥98% | 383418-30-2 | 25mg | $1052 | 2026-04-30 | Buy |
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Chemical Properties, Uses, Production
Description
HPA-12 is a ceramide analog and inhibitor of ceramide transfer protein (CERT). It inhibits binding of a ceramide probe to the isolated steroidogenic acute regulatory protein-related lipid transfer (START) domain of CERT with an EC50 value of 4 μM in a TR-FRET assay. HPA-12 (2.5 μM) inhibits conversion of the fluorescent ceramide analog C5-DMB-Cer to C5-DMB-sphingomyelin in CHO and HeLa cells. It also inhibits sphingomyelin synthesis in wild-type, but not ATP-dependent ceramide transport-deficient, CHO cells when used at a concentration of 1 μM.
Uses
HPA-12 is an intracellular ceramide transport protein inhibitor[1].
References
[1] Berke D, et al. Chemistry and Biology of HPAs: A Family of Ceramide Trafficking Inhibitors. Chemistry. 2016 Dec 5;22(49):17514-17525. DOI:10.1002/chem.201602947
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[(1R,3S)-3-Hydroxy-1-(hydroxymethyl)-3-phenylpropyl]dodecanamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shandong Ono Chemical Co., Ltd. | 0539-6362799 20） | China | 10007 | 58 | |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
