(1R,2R)-B13
- CAS No.
- 35922-06-6
- Chemical Name:
- (1R,2R)-B13
- Synonyms
- CAY10466;D-NMAPPD;(1R,2R)-B13;D-NMAPPD Exclusive;N-[(1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-NITROPHENYL)ETHYL]-TETRADECANAMIDE;Tetradecanamide, N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]-
- CBNumber:
- CB6143493
- Molecular Formula:
- C23H38N2O5
- Molecular Weight:
- 422.56
- MDL Number:
- MFCD08062172
- MOL File:
- 35922-06-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 636.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.101±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): .3 mg/ml |
| form | A crystalline solid |
| pka | 12.72±0.20(Predicted) |
| color | white to beige |
| optical activity | [α]/D -28 to -34, c =0.1 in chloroform-d |
| InChI | 1S/C23H38N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-22(27)24-21(18-26)23(28)19-14-16-20(17-15-19)25(29)30/h14-17,21,23,26,28H,2-13,18H2,1H3,(H,24,27)/t21-,23-/m1/s1 |
| InChIKey | XUSDVLHKNBOGJY-FYYLOGMGSA-N |
| SMILES | [N+](=O)([O-])c1ccc(cc1)[C@@H](O)[C@H](NC(=O)CCCCCCCCCCCCC)CO |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
(1R,2R)-B13 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2358 | D-NMAPPD ≥98% (HPLC) | 35922-06-6 | 5MG | $72.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2358 | D-NMAPPD ≥98% (HPLC) | 35922-06-6 | 25MG | $291 | 2026-04-30 | Buy |
| Cayman Chemical | 10006305 | D-NMAPPD ≥98% | 35922-06-6 | 1mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 10006305 | D-NMAPPD ≥98% | 35922-06-6 | 5mg | $118 | 2026-04-30 | Buy |
| Cayman Chemical | 10006305 | D-NMAPPD ≥98% | 35922-06-6 | 10mg | $217 | 2026-04-30 | Buy |
(1R,2R)-B13 Chemical Properties, Uses, Production
Uses
D-NMAPPD is d-NMAPPD is a potent Acid Ceramidase inhibitor that induces apoptosis..
Biological Activity
D-NMAPPD (B13), a myristoyl-CoA analog, is a cell penetrant inhibitor of N-myristoyltransferases th at suppressed FRS2α (fibroblast growth factor receptor substrate 2) myristoylation. D-NMAPPD inhibits wild-type FGFRs and drug-resistant mutants (FGFRsDRM) oncogenic signaling in cancer cells. D-NMAPPD potently inhibits growth of xenograft tumors in mice. D-NMAPPD is a potent inhibitor of ceramidase th at elevates endogenous ceramide levels and suppress growth of cancer cells.
(1R,2R)-B13 Preparation Products And Raw materials
Raw materials
Preparation Products
(1R,2R)-B13 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Beiwanta Biotechnology Co., Ltd. | 021-67187366 19901745723 | info@bwtlab.com | China | 9884 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 10000 | 58 |
