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Huperzine A

Huperzine A Structure
Huperzine A structure
CAS No.
120786-18-7
Chemical Name:
Huperzine A
Synonyms
SELAGINE;HUPERAZINE A;HUPERZINE A;[+/-]-SELAGINE;(+/-)-SELAGINE;(±)-Huperzine A;(+/-)-HuperzineA;(+/-)-HUPERZINE A;(+/-)-HUPERAZINE A;(±)-Huperzine A, >98%
CBNumber:
CB0308078
Molecular Formula:
C15H18N2O
Molecular Weight:
242.32
MDL Number:
MFCD00171439
MOL File:
120786-18-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Huperzine A Properties

Boiling point 505.0±50.0 °C(Predicted)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO : ≥ 50 mg/mL (206.34 mM)
form solid
pka 12.25±0.60(Predicted)
color White or off-white
InChI InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+
InChIKey ZRJBHWIHUMBLCN-QDEBKDIKSA-N
SMILES C12CC3/C(=C\C)/C(N)(C=1C=CC(=O)N2)CC(C)=C3
CAS DataBase Reference 120786-18-7
FDA UNII 0111871I23

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301+H311+H331-H315-H319-H335
Precautionary statements  P261-P280-P301+P310-P302+P352+P312-P304+P340+P311-P305+P351+P338
Hazard Codes  T
Risk Statements  23/24/25-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 1544 6.1/PG 2
WGK Germany  3
RTECS  PB9185700

Huperzine A price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H5777 (±)-Huperzine A synthetic, ≥98% (TLC) 120786-18-7 1mg $252 2026-04-30 Buy
Usbiological 451990 (+/-)-Huperzine A 120786-18-7 1mg $312 2026-06-03 Buy
Usbiological 451990 (+/-)-Huperzine A 120786-18-7 2.5mg $446 2026-06-03 Buy
ChemScene CS-1089 (±)-Huperzine A 98.73% 120786-18-7 5mg $78 2026-06-04 Buy
ChemScene CS-1089 (±)-Huperzine A 98.73% 120786-18-7 10mg $123 2026-06-04 Buy
Product number Packaging Price Buy
H5777 1mg $252 Buy
451990 1mg $312 Buy
451990 2.5mg $446 Buy
CS-1089 5mg $78 Buy
CS-1089 10mg $123 Buy

Huperzine A Chemical Properties, Uses, Production

Description

Huperzine A is an alkaloid extract derived from the Chinese club moss Huperzia serrata. It is an acetylcholinesterase inhibitor. This means it helps promote higher levels of acetylcholine in the brain. Higher levels of acetylcholine support ones ability to perform cognitive tasks such as learning new things, memorizing information, and focusing at the task at hand. Huperzine A is considered to be a nootropic supplement because it supports cognitive function. It is considered a focus and memory nootropic similar to alpha gpc, bacopa, phosphatidylcholine, cdp choline, sulbutiamine, and uridine. It is also considered a brain booster as it is used for brain health and support.
Huperzine A for many years has been widely used in traditional Chinese medicine to enhance memory and to treat fever and inflammation. In the United States it is commercially available as a food supplement, but has not been approved by the FDA as a treatment for AD or other cognition disorders.

Occurrence

The herbs of Lycopodium serratum.

Uses

Huperzine A is used for dementia in Alzheimer's disease and for muscle weakness in myasthenia gravis. In Alzheimer's disease, Huperzine A leads to significant improvements in memory and cognitive and behavioral function.

Application

(+/-)-Huperzine A is an NMDA antagonist. It has been used in anti-acetylcholinesterase bioautographic assay.

benefits

Huperzine A can help support learning and memory by protecting acetylcholine, a neurotransmitter that acts as a messenger molecule in the brain. Huperzine A may be used for both short-term "brain boost" needs, such as preparing for a test, as well as more long-term needs, such as reducing the mild memory loss associated with normal aging.
ACETYLCHOLINESTERASE INHIBITOR - Huperzine A acts as a reversible Acetylcholinesterase inhibitor meaning it supports levels of the neurotransmitter acetylcholine which plays a key role in cognitive function.
SUPPORTS COGNITIVE FUNCTION - Supports working memory, motivation, and problem solving ability.
SUPPORTS ENERGY AND STAMINA - Huperzine A supports mental energy, stamina, and sustained focus.

Biological Activity

Huperzine A is an effective acetylcholinesterase inhibitor and can cross the blood-brain barrier. Huperzine A is known to prevent cognitive defects, glutamate-induced nerve cell death.It is recognized for its use in the treatment of Alzheimer′s disease and organophosphate poisoning.

Side effects

When taken at recommended doses Huperzine A is well tolerated and presents few side effects. Rarely, side effects including nausea, diarrhea, and loss of appetite may occur. Adverse side effects are more likely when exceeding the recommended dosage.
Huperzine A is not recommended for people suffering from heart conditions, consult your physician before taking this product.

Dosage forms

Huperzine A supplementation tends to be in the range of 50 - 200 mcg daily. Our tablets are 200 mcg each, but can be easily broken into halves or quarters for those wishing to take smaller doses.
Huperzine A has a long half-life (10-14 hours), so cycling this product is often recommended. We recommend taking it no more than 2-3 times per week, or if using it daily we recommend taking a 1 week break for every 2 weeks of use.

Mode of action

Huperzine A is a reversible acetycholinesterase inhibitor that can cross the blood-brain barrier. This constituent can inhibit the activity of acetycholinesterase in the brain for several hours, which allows for increased levels of acetylcholine in different areas of the brain. Because of its effects on acetylcholine, Huperzine A is considered a beneficial therapuetic agent in the treatment of memory impairment, myasthenia gravis, and dementia.
Herbs and Nutrients for the Mind A Guide to Natural Brain Enhancers By Chris D. Meletis, Jason E. Barker · 2004

Huperzine A synthesis

120786-17-6
120786-18-7
Synthesis of Huperzine A from 5,9-Methanocycloocta[b]pyridine-5(6H)-carboxylic acid, 11-ethylidene-9,10-dihydro-2-methoxy-7-methyl-, methyl ester, (11E)-

Huperzine A Preparation Products And Raw materials

Raw materials

Carbamic acid, [(11E)-11-ethylidene-2,6,9,10-tetrahydro-7-methyl-2-oxo-5,9-methanocycloocta[b]pyridin-5(1H)-yl]-, methyl ester (9CI) 5,9-Methanocycloocta[b]pyridine-5(6H)-carboxylic acid, 11-ethylidene-9,10-dihydro-2-methoxy-7-methyl-, methyl ester, (11E)-

Preparation Products

Huperzine A Suppliers

Global Suppliers ( 218)
Supplier Tel Email Country ProdList Advantage
Jiangsu Huayu Chemical Co., Ltd. 25-83241163 sales@elegantnutri.com China 55 55
Chengdu Chenlv Herb Co., Ltd. 028-88523492 15528171243 chenrongpharma@126.com China 124 58
Shaanxi Pioneer Biotech Co., Ltd 15376736214 sales17@pioneerbiotech.com China 434 58
Hangzhou Zyter Biological & Chemical Technology Co., Ltd. 18858184290; sales@zyterpharm.com China 47 49
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16307 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
XiaoGan ShenYuan ChemPharm co,ltd 15527621225; 15527621225 1791901229@qq.com China 6732 52
Supplier Advantage
Jiangsu Huayu Chemical Co., Ltd. 55
Chengdu Chenlv Herb Co., Ltd. 58
Shaanxi Pioneer Biotech Co., Ltd 58
Hangzhou Zyter Biological & Chemical Technology Co., Ltd. 49
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Nanjing Chemlin Chemical Co., Ltd 64
China DongFan Chemical Co.,LTD 66
XiaoGan ShenYuan ChemPharm co,ltd 52

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View Latest Price from Huperzine A manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Huperzine A pictures 2026-10-13 Huperzine A
120786-18-7
 1G 98%min 30KG/month WUHAN FORTUNA CHEMICAL CO., LTD
Huperzine A pictures 2026-10-13 Huperzine A
120786-18-7
 $60.00 1G 98% 99% 10000 Changsha Staherb Natural Ingredients Co., Ltd.
Huperzine A pictures 2026-10-13 Huperzine A
120786-18-7
 1kg 1-98% 1000kg Changsha Staherb Natural Ingredients Co., Ltd.
  • Huperzine A pictures
  • Huperzine A
    120786-18-7
  • $0.00
  • 98%min
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • Huperzine A pictures
  • Huperzine A
    120786-18-7
  • $60.00
  • 98% 99%
  • Changsha Staherb Natural Ingredients Co., Ltd.
  • Huperzine A pictures
  • Huperzine A
    120786-18-7
  • 1-98%
  • Changsha Staherb Natural Ingredients Co., Ltd.

Huperzine A Spectrum

Huperzine A(120786-18-7)1HNMR

120786-18-7 (Huperzine A) Related Search:

Galantamine Hydrobromide Matrine Ursolic acid D-(-)-Salicin 6-[5-[(2S)-2-Azetidinylmethoxy]-3-pyridinyl]-5-hexyn-1-ol dihydrochloride
4-(N-[3-Chlorophenyl]-carbamoyloxy)-2-butynyltrimethylammonium chloride 2-(3-Pyridinyl)piperidine hydrochloride (-)-HUPERZINE A, 99% HPLC,(-)-Huperzine A,Huperzine A ( Selagine ),(-)-HUPERZINE A FROM HUPERZIA SERRATA,Huperzine-A1-5%,HUPERZINE A 1% HUPERZINE Huperzine A
(-)-HUPERZINE A, HUPERZIA SERRATA +/- HUPERZINE MW= 242.3 Huperzine Serrate P.E. HUPERZINE-A,CRUDE HUPERZINE B
HUPERZINE-A,PURE HUPERZINE A WHITE POWDER

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(+/-)-SELAGINE [+/-]-SELAGINE (11E)-5-Amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one (±)-Huperzine A, >98% 1-Amino-13-ethylidene-11-methyl-6-aza-tricyclo[7.3.1.02,7]trideca-2(7),3,10-trien-5-one (+/-)-HUPERAZINE A HUPERAZINE A (+/-)-HUPERZINE A HUPERZINE A ((plusmn))-Huperzine A Huperzia Serrata Extract (Standard) 5,9-Methanocycloocta[b]pyridin-2(1H)-one, 5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-, (11E)- (+/-)-HuperzineA Huperzine A USP/EP/BP (±)-Huperzine A solution (E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one Cholinesterase (ChE),inhibit,Inhibitor,(±)-Huperzine A,(±) Huperzine A,(±)Huperzine A (±)-Huperzine A, 10 mM in DMSO (±)-Huperzine A SELAGINE 120786-18-7 Cholinesterase, acetyl Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates A to C Biochemicals and Reagents BioChemical Herb extract Natural Plant Extract Acetylcholine receptor