4-(1H-Pyrazol-1-yl)benzylamine
- CAS No.
- 368870-03-5
- Chemical Name:
- 4-(1H-Pyrazol-1-yl)benzylamine
- Synonyms
- AKOS B014367;BUTTPARK 98\50-46;CHEMBRDG-BB 4003287;ART-CHEM-BB B014367;ART-CHEM-BB B020480;4-(1-PYRAZOLYL)BENZYLAMINE;4-PYRAZOL-1-YL-BENZYLAMINE;4-(1H-pyrazol-1-)benzylamine;4-(1H-Pyrazol-1-yl)benzylamine;4-(1H-pyrazol-1-yl)benzylamine97%
- CBNumber:
- CB0308452
- Molecular Formula:
- C10H11N3
- Molecular Weight:
- 173.21
- MDL Number:
- MFCD02682058
- MOL File:
- 368870-03-5.mol
- MSDS File:
- SDS
| Melting point | 94-95°C |
|---|---|
| Boiling point | 307.1±25.0 °C(Predicted) |
| Density | 1.16±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 8.89±0.10(Predicted) |
| Appearance | Off-white to yellow Solid |
| InChI | InChI=1S/C10H11N3/c11-8-9-2-4-10(5-3-9)13-7-1-6-12-13/h1-7H,8,11H2 |
| InChIKey | AVKMXPDYQVKSFF-UHFFFAOYSA-N |
| SMILES | C1(CN)=CC=C(N2C=CC=N2)C=C1 |
| CAS DataBase Reference | 368870-03-5 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280-P309+P311 |
| Hazard Codes | C,Xi |
| Risk Statements | 34-41-37/38 |
| Safety Statements | 26-36/37/39-39 |
| RIDADR | 2735 |
| Hazard Note | Corrosive |
| HS Code | 2921490090 |
4-(1H-Pyrazol-1-yl)benzylamine price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR23296 | [4-(1H-Pyrazol-1-yl)phenyl]methylamine 95% | 368870-03-5 | 250mg | $55 | 2026-06-04 | Buy |
| Apolloscientific | OR23296 | [4-(1H-Pyrazol-1-yl)phenyl]methylamine 95% | 368870-03-5 | 1g | $128 | 2026-06-04 | Buy |
| Activate Scientific | AS38566 | 4-(1H-Pyrazol-1-yl)benzylamine 95% | 368870-03-5 | 1g | $254 | 2026-06-04 | Buy |
| Apolloscientific | OR23296 | [4-(1H-Pyrazol-1-yl)phenyl]methylamine 95% | 368870-03-5 | 5g | $379 | 2026-06-04 | Buy |
| Activate Scientific | AS38566 | 4-(1H-Pyrazol-1-yl)benzylamine 95% | 368870-03-5 | 5g | $795 | 2026-06-04 | Buy |
4-(1H-Pyrazol-1-yl)benzylamine Chemical Properties, Uses, Production
Synthesis
25699-83-6
368870-03-5
General procedure for the synthesis of 4-(1H-pyrazolyl)benzenemethanamine from 4-(1H-pyrazolyl)benzonitrile: To 4-(1H-pyrazolyl)benzonitrile (1.46 g, 8.63 mmol) was added a tetrahydrofuran solution (93 ml, 93 mmol) of 1 M borane-tetrahydrofuran complex and heated to reflux. After 16 hours of reaction, methanol (14 ml) was added to the reaction solution, which was subsequently concentrated under reduced pressure. To the residue 6N hydrochloric acid (265 ml) was added and heating to reflux was continued for 3 hours. After completion of the reaction, the solution was concentrated under reduced pressure and a small amount of water was added. The pH was adjusted to 11 with 30% aqueous sodium hydroxide under cooling in an ice bath and subsequently extracted with dichloromethane. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: chloroform:methanol:28% ammonia = 90:10:1, V/V/V), the fraction containing the target compound was collected and concentrated under reduced pressure to afford the title compound 4-(1H-pyrazolyl)benzylamine (1.24 g, 83% yield) as a light yellow solid. Mass spectrum (CI, m/z): 174 (M++1). 1H-NMR spectrum (CDCl3, ppm): 7.91 (dd, J=2.5,0.5Hz, 1H), 7.72 (d, J=1.6Hz, 1H), 7.69-7.63 (m, 2H), 7.44-7.37 (m, 2H), 6.46 (dd, J=2.5, 1.6Hz, 1H). 1.6 Hz, 1H), 3.91 (s, 2H).
References
[1] Patent: EP2264009, 2010, A1. Location in patent: Page/Page column 103
[2] Patent: EP2415763, 2012, A1. Location in patent: Page/Page column 105
[3] Patent: WO2017/87837, 2017, A1. Location in patent: Paragraph 00270
[4] Patent: US2013/123281, 2013, A1. Location in patent: Paragraph 0127
[5] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 231
4-(1H-Pyrazol-1-yl)benzylamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Co TC SR Technology Co., Ltd. | 027-13487090-306 13487090306 | 48011371@qq.com | China | 98 | 58 |
| Shanghai Yaoheping Biopharmaceutical Technology Co., Ltd | 57540919 13120888836 | lily@yhp-biomedicine.com | China | 9246 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Wuhan Target Pharm Co.,Ltd | 0086-27-81360461 | hustzsy@hotmail.com | China | 52 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Wuhan Kaymke Chemical Co., Ltd., | 027-87342388 18086026008 | sales@kaymke.com | China | 3537 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 |
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