4-Pyrazol-1-yl-benzonitrile
- CAS No.
- 25699-83-6
- Chemical Name:
- 4-Pyrazol-1-yl-benzonitrile
- Synonyms
- 4-(1H-PyrazoL;4-(1H-Pyrazol-1-yl);1-(4-Cyanophenyl)pyrazole;4-Pyrazol-1-yl-benzonitrile;4-(1-Pyrazolyl)benzonitrile;Benzonitrile, p-pyrazol-1-yl-;Benzonitrile, 4-(1H-pyrazol-1-yl)-
- CBNumber:
- CB4803728
- Molecular Formula:
- C10H7N3
- Molecular Weight:
- 169.18
- MDL Number:
- MFCD09033533
- MOL File:
- 25699-83-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 89 °C |
|---|---|
| Boiling point | 316.5±25.0 °C(Predicted) |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -0.63±0.10(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C10H7N3/c11-8-9-2-4-10(5-3-9)13-7-1-6-12-13/h1-7H |
| InChIKey | SLPWCEHHSRUSKN-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(N2C=CC=N2)C=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319 | |||||||||
| Precautionary statements | P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312 | |||||||||
| Hazard Codes | Xi | |||||||||
| RIDADR | UN3439 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933199090 | |||||||||
| NFPA 704 |
|
4-Pyrazol-1-yl-benzonitrile price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | P2450 | 4-(1-Pyrazolyl)benzonitrile >98.0%(GC) | 25699-83-6 | 1g | $44 | 2026-04-30 | Buy |
| TCI Chemical | P2450 | 4-(1-Pyrazolyl)benzonitrile >98.0%(GC) | 25699-83-6 | 5g | $173 | 2026-04-30 | Buy |
| Apolloscientific | OR111078 | 4-(1H-Pyrazol-1-yl)benzonitrile 97% | 25699-83-6 | 25g | $62 | 2026-06-04 | Buy |
| Apolloscientific | OR111078 | 4-(1H-Pyrazol-1-yl)benzonitrile 97% | 25699-83-6 | 100g | $240 | 2026-06-04 | Buy |
| Chem-Impex | 43601 | 4-(1-Pyrazolyl)benzonitrile ≥98%(GC) | 25699-83-6 | 1G | $36.35 | 2026-05-19 | Buy |
4-Pyrazol-1-yl-benzonitrile Chemical Properties, Uses, Production
Synthesis
288-13-1
1194-02-1
25699-83-6
The general procedure for the synthesis of 4-(1-pyrazolyl)benzonitrile from pyrazole and p-fluorobenzonitrile was as follows: 4-fluorobenzonitrile (204.2 g, 1.0 eq.), pyrazole (138.6 g, 1.22 eq.), and potassium carbonate (281.5 g, 1.22 eq.) were dissolved in DMF (1110 mL), and heated to a temperature of 120°C for 7 hours. After completion of the reaction, the suspension was cooled to 25 °C and diluted with water (2920 mL). The reaction mixture was extracted with methyl tert-butyl ether (MTBE, 3 x 1460 mL), and the organic phases were combined and washed sequentially with water (3 x 1460 mL) and saturated aqueous sodium chloride solution (1460 mL). The organic phase was concentrated at atmospheric pressure until the tank temperature rose to 65 °C, then heptane (1700 mL) was added over 30 min at 60-65 °C and distillation was continued to collect 300 mL of distillate. The solution was stirred at 60-65°C for 15 minutes and subsequently cooled to <5°C. The resulting slurry was filtered, the solid was washed with heptane (2 x 200 mL) and dried under vacuum to constant weight to afford the target product 4-(1-pyrazolyl)benzonitrile as a white solid (245.3 g, 87% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 6.51 (q, 1H), 7.71 (d, 2H), 7.75 (d, 1H), 7.81 (d, 2H), 7.98 (d, 1H).
References
[1] Patent: WO2009/61271, 2009, A1. Location in patent: Page/Page column 45-46
[2] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 2955 - 2959
[3] Patent: US2011/224229, 2011, A1. Location in patent: Page/Page column 19
[4] Patent: WO2017/87837, 2017, A1. Location in patent: Paragraph 00269
[5] Patent: US9301951, 2016, B2. Location in patent: Page/Page column 231
4-Pyrazol-1-yl-benzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Co TC SR Technology Co., Ltd. | 027-13487090-306 13487090306 | 48011371@qq.com | China | 98 | 58 |
| Xingtai Zhuowang Biotechnology Co. , Ltd. | 15227351060; 15227351060 | 1032018463@qq.com | China | 90 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Acorn PharmaTech Co., Ltd. | 025-58395930 | sales@acornpharma.com | China | 982 | 60 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
View Latest Price from 4-Pyrazol-1-yl-benzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 4-PYRAZOL-1-YL-BENZONITRILE
25699-83-6
|
1KG | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 4-PYRAZOL-1-YL-BENZONITRILE
25699-83-6
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- 4-PYRAZOL-1-YL-BENZONITRILE
25699-83-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-PYRAZOL-1-YL-BENZONITRILE
25699-83-6
- $1.00
- 98%
- Career Henan Chemical Co
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