Nisoldipine-d6
- CAS No.
- 1285910-03-3
- Chemical Name:
- Nisoldipine-d6
- Synonyms
- 3-methyl 5-(2-(methyl-d3)propyl-3,3,3-d3) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Nisoldipine D6Q: What is Nisoldipine D6 Q: What is the CAS Number of Nisoldipine D6 Q: What is the storage condition of Nisoldipine D6 Q: What are the applications of Nisoldipine D6
- CBNumber:
- CB03118124
- Molecular Formula:
- C20H24N2O6
- Molecular Weight:
- 388.42
- MDL Number:
- MOL File:
- 1285910-03-3.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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| Signal word | Warning | |||||||||
| NFPA 704 |
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Nisoldipine-d6 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 31785 | Nisoldipine-d6 ≥99%deuteratedforms(d1-d6) | 1285910-03-3 | 500μg | $174 | 2026-04-30 | Buy |
| Cayman Chemical | 31785 | Nisoldipine-d6 ≥99%deuteratedforms(d1-d6) | 1285910-03-3 | 1mg | $329 | 2026-04-30 | Buy |
| Biosynth | KBC91003 | Nisoldipine-d6 | 1285910-03-3 | 5mg | $1813.95 | 2026-06-04 | Buy |
| Biosynth | KBC91003 | Nisoldipine-d6 | 1285910-03-3 | 10mg | $2902.3 | 2026-06-04 | Buy |
| Biosynth | KBC91003 | Nisoldipine-d6 | 1285910-03-3 | 25mg | $5441.75 | 2026-06-04 | Buy |
Nisoldipine-d6 Chemical Properties, Uses, Production
Uses
Nisoldipine-d6 is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM.
Biological Activity
Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor.1 It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.1,2 Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).1 In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.3 Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.4 Formulations containing nisoldipine have been used in the treatment of hypertension.
References
1.Knorr, A.The pharmacology of nisoldipineCardiovasc. Drugs Ther.1(4)393-402(1987) 2.Janis, R.A., Shrikhande, A.V., Greguski, R., et al.Review of nisoldipine binding studiesNisoldipine 198727-35(1987) 3.Fagbemi, O., and Parratt, J.R.Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemiaBr. J. Pharmacol.74(1)12-14(1981) 4.Stasch, J.-P., Kazda, S., Hirth, C., et al.Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive ratsHypertension10(3)303-307(1987)
Nisoldipine-d6 Preparation Products And Raw materials
Raw materials
Preparation Products
Nisoldipine-d6 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Quality Control Solutions Ltd. | 0755-66853366 13670046396 | orders@qcsrm.com | China | 18188 | 56 |
| ChemeGen | 18818260767 | 2625930290@qq.com | China | 6966 | 58 |
| CHINA ISOTOPE CO., LIMITED | 02151600108 13062666369 | info@isotopechem.com | China | 4721 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 17301488900 | judy.xia@synzest.com | China | 12577 | 58 |
| Shandong Dayou Pharmaceutical Research and Development Co., Ltd. | hanfangpharma@126.com 15165037910 | hanfangpharma@126.com | China | 25800 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8143 | 58 |
