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| | Nisoldipine-d6 Basic information |
| Product Name: | Nisoldipine-d6 | | Synonyms: | Nisoldipine D6Q: What is
Nisoldipine D6 Q: What is the CAS Number of
Nisoldipine D6 Q: What is the storage condition of
Nisoldipine D6 Q: What are the applications of
Nisoldipine D6;3-methyl 5-(2-(methyl-d3)propyl-3,3,3-d3) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate | | CAS: | 1285910-03-3 | | MF: | C20H24N2O6 | | MW: | 388.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1285910-03-3.mol |  |
| | Nisoldipine-d6 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Acetonitrile: Soluble | | form | A solid |
| | Nisoldipine-d6 Usage And Synthesis |
| Uses | Nisoldipine-d6 is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552; Sular) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with an IC50 of 10 nM. | | Biological Activity | Nisoldipine-d6 is intended for use as an internal standard for the quantification of nisoldipine by GC- or LC-MS. Nisoldipine is a calcium channel inhibitor.1 It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells.1,2 Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM).1 In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia.3 Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats.4 Formulations containing nisoldipine have been used in the treatment of hypertension. | | References | 1.Knorr, A.The pharmacology of nisoldipineCardiovasc. Drugs Ther.1(4)393-402(1987)
2.Janis, R.A., Shrikhande, A.V., Greguski, R., et al.Review of nisoldipine binding studiesNisoldipine 198727-35(1987)
3.Fagbemi, O., and Parratt, J.R.Suppression by orally-administered nifedipine, nisoldipine and niludipine of early, life-threatening ventricular arrhythmias resulting from acute myocardial ischaemiaBr. J. Pharmacol.74(1)12-14(1981)
4.Stasch, J.-P., Kazda, S., Hirth, C., et al.Role of nisoldipine on blood pressure, cardiac hypertrophy, and atrial natriuretic peptides in spontaneously hypertensive ratsHypertension10(3)303-307(1987) |
| | Nisoldipine-d6 Preparation Products And Raw materials |
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