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2-Chloro-4-cyclopropoxypyridine

2-Chloro-4-cyclopropoxypyridine Structure
2-Chloro-4-cyclopropoxypyridine structure
CAS No.
1209458-93-4
Chemical Name:
2-Chloro-4-cyclopropoxypyridine
Synonyms
2-Chloro-4-cyclopropoxypyridine;Pyridine, 2-chloro-4-(cyclopropyloxy)-
CBNumber:
CB03130528
Molecular Formula:
C8H8ClNO
Molecular Weight:
169.61
MDL Number:
MOL File:
1209458-93-4.mol
Last updated:2025-07-24 18:13:44
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2-Chloro-4-cyclopropoxypyridine Properties

Boiling point 265.7±20.0 °C(Predicted)
Density 1.326±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
pka 2.18±0.10(Predicted)

2-Chloro-4-cyclopropoxypyridine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Activate Scientific AS185640 2-Chloro-4-cyclopropoxypyridine 97% 1209458-93-4 100mg $166 2026-06-04 Buy
Activate Scientific AS185640 2-Chloro-4-cyclopropoxypyridine 97% 1209458-93-4 250mg $272 2026-06-04 Buy
Activate Scientific AS185640 2-Chloro-4-cyclopropoxypyridine 97% 1209458-93-4 1g $653 2026-06-04 Buy
Activate Scientific AS185640 2-Chloro-4-cyclopropoxypyridine 97% 1209458-93-4 5g $1961 2026-06-04 Buy
aablocks AA01K02T 2-Chloro-4-cyclopropoxypyridine 97% 1209458-93-4 100mg $85 2026-05-30 Buy
Product number Packaging Price Buy
AS185640 100mg $166 Buy
AS185640 250mg $272 Buy
AS185640 1g $653 Buy
AS185640 5g $1961 Buy
AA01K02T 100mg $85 Buy

2-Chloro-4-cyclopropoxypyridine Chemical Properties, Uses, Production

Synthesis

2-Chloro-4-hydroxypyridine

17368-12-6

Cyclopropyl bromide

4333-56-6

2-Chloro-4-cyclopropoxypyridine

1209458-93-4

To a solution of N,N-dimethylacetamide (DMA, 10 ml) of 2-chloro-4-hydroxypyridine (1 g, 7.75 mmol) was sequentially added bromocyclopropane (2.8 g, 23.2 mmol), sodium iodide (1.16 g, 7.75 mmol) and cesium carbonate (5 g, 15.5 mmol). The reaction mixture was stirred in a microwave reactor at 170 °C for 20 min, followed by warming up to 180 °C and continued stirring for 30 min. After completion of the reaction, the reaction mixture was extracted with ethyl acetate (EA). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography to give 300 mg of 2-chloro-4-cyclopropoxypyridine. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ= 8.19 (d, J = 5.8 Hz, 1H), 7.02 (d, J = 2.0 Hz, 1H), 6.87 (dd, J = 2.0,5.8 Hz, 1H), 3.80 (tt, J = 3.0,6.0 Hz, 1H), 0.91-0.75 (m, 4H) .

References

[1] Patent: WO2014/114185, 2014, A1. Location in patent: Page/Page column 162
[2] Patent: US2014/206681, 2014, A1. Location in patent: Paragraph 0889; 0890
[3] Patent: WO2014/113932, 2014, A1. Location in patent: Page/Page column 119

2-Chloro-4-cyclopropoxypyridine synthesis

17368-12-6
4333-56-6
1209458-93-4
Synthesis of 2-Chloro-4-cyclopropoxypyridine from 2-Chloro-4-hydroxypyridine and Cyclopropyl bromide

2-Chloro-4-cyclopropoxypyridine Preparation Products And Raw materials

Raw materials

2-Chloro-4-hydroxypyridine Cyclopropyl bromide N,N-Dimethylacetamide Sodium iodide Cesium carbonate

Preparation Products

2-Chloro-4-cyclopropoxypyridine Suppliers

Global Suppliers ( 2)
Supplier Tel Email Country ProdList Advantage
Shaanxi PharmaGHS Science Co., LTD 029-13279368192 13279368192 pharmaghs@126.com China 2913 58
Hefei Molybdenum Kai Pharmaceutical Technology Co., Ltd 18001872185; 18001872185 690231469@qq.com China 18392 58
Supplier Advantage
Shaanxi PharmaGHS Science Co., LTD 58
Hefei Molybdenum Kai Pharmaceutical Technology Co., Ltd 58
2-Chloro-4-cyclopropoxypyridine Pyridine, 2-chloro-4-(cyclopropyloxy)- 1209458-93-4