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2-Chloro-4-hydroxypyridine

2-Chloro-4-hydroxypyridine Structure
2-Chloro-4-hydroxypyridine structure
CAS No.
17368-12-6
Chemical Name:
2-Chloro-4-hydroxypyridine
Synonyms
2-CHLOROPYRIDIN-4-OL;12.15;2-CHLORO-4-PYRIDINOL;2-Chloro-4-hydroxypy;4-Pyridinol, 2-chloro-;Oliceridine Impurity 18;2-chloro-1H-pyridin-4-one;2-CHLORO-4-HYDROXYPYRIDINE;2-Chloro-4-hydroxylpyridine;2-Chloro-4-hydroxypyridine95%
CBNumber:
CB7307520
Molecular Formula:
C5H4ClNO
Molecular Weight:
129.54
MDL Number:
MFCD01646108
MOL File:
17368-12-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:13:31
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2-Chloro-4-hydroxypyridine Properties

Melting point 169-172°C
Boiling point 401.8±25.0 °C(Predicted)
Density 1.392±0.06 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 7.94±0.10(Predicted)
color White to Light yellow to Light orange
InChI InChI=1S/C5H4ClNO/c6-5-3-4(8)1-2-7-5/h1-3H,(H,7,8)
InChIKey VBEHFOMFHUQAOW-UHFFFAOYSA-N
SMILES C1(Cl)=NC=CC(O)=C1
CAS DataBase Reference 17368-12-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-22
Safety Statements  26-36
HS Code  2933399990
NFPA 704
1
2 0

2-Chloro-4-hydroxypyridine price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C2516 2-Chloro-4-hydroxypyridine >97.0%(GC)(T) 17368-12-6 1g $18 2026-04-30 Buy
TCI Chemical C2516 2-Chloro-4-hydroxypyridine >97.0%(GC)(T) 17368-12-6 5g $62 2026-04-30 Buy
AstaTech CL0074 2-CHLORO-4-HYDROXYPYRIDINE 97% 17368-12-6 25G $53 2026-04-30 Buy
AstaTech CL0074 2-CHLORO-4-HYDROXYPYRIDINE 97% 17368-12-6 100G $185 2026-04-30 Buy
ChemScene CS-D1163 2-Chloro-4-hydroxypyridine ≥95% 17368-12-6 5g $10 2026-06-04 Buy
Product number Packaging Price Buy
C2516 1g $18 Buy
C2516 5g $62 Buy
CL0074 25G $53 Buy
CL0074 100G $185 Buy
CS-D1163 5g $10 Buy

2-Chloro-4-hydroxypyridine Chemical Properties, Uses, Production

Chemical Properties

White crystal

Uses

2-Chloro-4-hydroxypyridine is a chemical that is used as a building block for various organic synthesis reactions. 

Preparation

2-Chloro-4-hydroxypyridine can be produced by the reaction of chloroform and pyridine, which results in the formation of 2-chloro-4-hydroxypyridine.

Reactions

2-Chloro-4-hydroxypyridine has been shown to react with copper metal under dehydrogenative conditions to form monochloropyridine. It also reacts with tribromide to form tribromopyridine and with graphene oxide to form hydroxypyridinium bromide. Lastly, it reacts with an organic solvent such as acet.

Synthesis

4-Amino-2-chloropyridine

14432-12-3

2-Chloro-4-hydroxypyridine

17368-12-6

The general procedure for the synthesis of 2-chloro-4-hydroxypyridine from 2-chloro-4-aminopyridine is as follows: in a round-bottomed flask, 2-chloro-4-aminopyridine (3.0 g, 23.3 mmol) was dissolved in 40% sulfuric acid solution (50 g). The solution was stirred at 0 °C and sodium nitrite (1.93 g, 28.0 mmol) was added slowly. After addition, the reaction mixture was stirred continuously at room temperature for 24 hours. Upon completion of the reaction, the reaction solution was neutralized by dropwise addition of aqueous sodium hydroxide and aqueous sodium bicarbonate. Subsequently, the organic phase was extracted with ethyl acetate. The organic phase was dried over anhydrous magnesium sulfate, filtered, distilled to remove the solvent and dried under reduced pressure to give 2-chloro-4-hydroxypyridine (light brown solid, 2.78 g, 92% yield). The product was characterized by 1H-NMR (270 MHz, DMSO-d6): δ 11.20 (s, 1H, -OH), 8.09 (d, 1H, J = 5.4 Hz, ArH), 6.81 (s, 1H, ArH), 6.77 (d, 1H, J = 2.2 Hz, ArH).

References

[1] Patent: WO2009/11447, 2009, A2. Location in patent: Page/Page column 37-38

2-Chloro-4-hydroxypyridine synthesis

14432-12-3
17368-12-6
Synthesis of 2-Chloro-4-hydroxypyridine from 4-Amino-2-chloropyridine

2-Chloro-4-hydroxypyridine Preparation Products And Raw materials

Raw materials

2-Chloropyridine-4-boronic acid pinacol ester 2-Chloro-4-methoxypyridine 2-Chloro-4-pyridylboronic acid 2-chloro-4-pyridone 2-Chloro-4-nitropyridine
2-Chloro-4-bromopyridine 4-Amino-2-chloropyridine Sulfuric acid Sodium hydroxide Sodium nitrite

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Preparation Products

tert-Butyl 4-(4-hydroxypyridin-2-yl)piperazine-1-carboxylate 2-Chloro-4-cyclopropoxypyridine Pyridine,2-chloro-4-(2,5-difluoro-4-nitrophenoxy)-

2-Chloro-4-hydroxypyridine Suppliers

Global Suppliers ( 336)
Supplier Tel Email Country ProdList Advantage
skychemical Co.Ltd 021-20960837,QQ1332204249 sales@skychemical.com China 3338 55
Nanjing Sifanke Chemical Co.LTD 025-58699658 13814094318 985496172@qq.com China 511 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing dtftchem Technology Co., Ltd. 010-60275820 13031183356 elainezt@sina.com China 1386 62
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
skychemical Co.Ltd 55
Nanjing Sifanke Chemical Co.LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Beijing dtftchem Technology Co., Ltd. 62
Energy Chemical 61

View Latest Price from 2-Chloro-4-hydroxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-4-hydroxypyridine pictures 2026-08-20 2-Chloro-4-hydroxypyridine
17368-12-6
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Chloro-4-hydroxypyridine pictures 2026-03-20 2-Chloro-4-hydroxypyridine
17368-12-6
 $8.00-10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Chloro-4-hydroxypyridine pictures 2024-04-25 2-Chloro-4-hydroxypyridine
17368-12-6
 $5.00 1kg 99.92% 50000tons Ouhuang Engineering Materials (Hubei) Co., Ltd

2-Chloro-4-hydroxypyridine Spectrum

2-Chloro-4-hydroxypyridine(17368-12-6)1HNMR

17368-12-6 (2-Chloro-4-hydroxypyridine) Related Search:

4-Hydroxypyridine 2-Chloro-5-chloromethylpyridine 2-Chloro-4-iodopyridine Clopidol 2-Chloro-4-bromopyridine
2-Chloro-4-fluoropyridine 4(1H)-Pyrimidinone, 2-chloro- (9CI) 2,3,5,6-tetrafluoro-4-mercapto-Benzoic acid 6-Chloro-2-hydroxypyridine,2-Chloro-6-hydroxypyridine, 98+% 2-Chloro-3-hydroxypyridine
2-CHLORO-5-HYDROXYPYRIDINE 99+%,2-CHLORO-5-HYDROXYPYRIDINE 98%,2-CHLORO-5-HYDROXYPYRIDINE 2,3,5,6-Tetrafluorothiophenol 4-Trifluoromethyl-2,3,5,6-tetrafluorothiophenol Pentafluorobenzenesulfonyl chloride Pentafluorothiophenol
Pentafluorobenzenesulfenyl chloride Difluorochloromethane 3,5-Dichloro-4-hydroxypyridine

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2-CHLORO-4-HYDROXYPYRIDINE 2-CHLORO-4-PYRIDINOL 4-Pyridinol,2-chloro-(7CI,8CI,9CI) 2-Chloro-4-hydroxypyridine HCl Salt 2-CHLORO-4-HYDROXYPYRIDINE 99% 2-Chloro-4-hydroxypyridine hydrochloride 2-chloro-1H-pyridin-4-one 12.15 2-Chloro-4-hydroxypy 2-Chloro-4-hydroxylpyridine 4-Pyridinol, 2-chloro- 2-Chloro-4-hydroxypyridine95% 2-Chloro-4-hydroxypyridine > 2-Chloro-4-hydroxypyridine ISO 9001：2015 REACH Oliceridine Impurity 18 2-CHLOROPYRIDIN-4-OL 17368-12-6 78067-36-0 13768-12-6 CHIRAL CHEMICALS PYRIDINE blocks Pyridines