Eggmanone
- CAS No.
- 505068-32-6
- Chemical Name:
- Eggmanone
- Synonyms
- Eggmanone;3-(2-methylprop-2-enyl)-2-(2-oxo-2-thiophen-2-ylethyl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one;5,6,7,8-Tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-[1]benzothieno[2,3-d]pyrimidin-4(3H)-one;[1]Benzothieno[2,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-3-(2-methyl-2-propen-1-yl)-2-[[2-oxo-2-(2-thienyl)ethyl]thio]-
- CBNumber:
- CB03152609
- Molecular Formula:
- C20H20N2O2S3
- Molecular Weight:
- 416.58
- MDL Number:
- MOL File:
- 505068-32-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Eggmanone price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17751 | Eggmanone ≥95% | 505068-32-6 | 1mg | $90 | 2026-04-30 | Buy |
| Cayman Chemical | 17751 | Eggmanone ≥95% | 505068-32-6 | 5mg | $392 | 2026-04-30 | Buy |
| Cayman Chemical | 17751 | Eggmanone ≥95% | 505068-32-6 | 10mg | $696 | 2026-04-30 | Buy |
| ChemScene | CS-0079344 | Eggmanone 95.31% | 505068-32-6 | 1mg | $206 | 2026-06-04 | Buy |
| ApexBio Technology | C4796 | Eggmanone | 505068-32-6 | 1mg | $115 | 2026-05-06 | Buy |
Eggmanone Chemical Properties, Uses, Production
Uses
Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers. Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway. It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 μM, respectively). Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.[Cayman Chemical]
Uses
Eggmanone is used in the synthetic preparation of thieno/benzopyrimidinone inhibitors of Hedgehog signaling for potential cancer therapy. Phosphodiesterase (PDE) 4 inhibitor. Exhibits >40-fold selectivity over PDE3, PDE10, and PDE11
Biological Activity
eggmanone is a potent and selective pde4d3 inhibitor with ic50 value of 72 nm that antagonizes the hedgehog signaling pathway [1].hedgehog (hh) signaling plays an important role in vertebrate development, and its dysregulation is a driver of numerous malignancies. phosphodiesterase 4 (pde4) is a target for hh inhibition. eggmanone exerts its hh-inhibitory effects through selective antagonism of pde4, leading to protein kinase a activation and subsequent hh blockade [1].eggmanone is a potent and selective pde4 inhibitor that antagonizes the hedgehog signaling pathway. in sufu-/- mouse embryonic fibroblasts (mefs), eggmanone significantly reduced transcription levels of gli1 and ptc1. eggmanone functioned upstream of gli processing and nuclear translocation to exert its hh-inhibitory effects. eggmanone exhibited potent antagonism of pde4d3 with ic50 value of 0.072 μm, approximately 40- to 50-fold selective over pde3a, pde10a2, and pde11a4 (ic50s = 3, 3.05, and 4.08 μm, respectively). in shh-light2 cells transfected with pde4d3, eggmanone restored the increased hh signaling [1].
References
[1]. williams ch, hempel je, hao j, et al. an in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. cell rep. 2015 apr 7;11(1):43-50.
Eggmanone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5985 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 50068 | 58 |
