Eggmanone manufacturers and suppliers

Eggmanone suppliers

Eggmanone

CAS:: 505068-32-6

MF:: C20H20N2O2S3

MW:: 416.58

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Properties

storage temp.: Store at -20°C

solubility: ≤0.5mg/ml in ethanol;10mg/ml in DMSO;5mg/ml in dimethyl formamide

form: crystalline solid

color: brown

Safety Information

WGK Germany: WGK 3

Storage Class: 11 - Combustible Solids

Use

Type 4 cyclic nucleotide phosphodiesterase (PDE4) selectively inactivates the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. PDE4 has been reported to play a key regulatory role in Hedgehog signaling downstream of smoothened and, thus, represents a potential therapeutic target for Hedgehog-dependent cancers. Eggmanone is a selective inhibitor of PDE4 (IC50 = 72 nM) that antagonizes the Hedgehog signaling pathway. It demonstrates 40- to 50-fold lower potency at PDE3, PDE10, and PDE11 (IC50s = 3, 3.05, and 4.08 μM, respectively). Inhibition of PDE4 activity via eggmanone was shown to activate localized protein kinase A signaling, which, in turn, regulates Gli processing and translocation.[Cayman Chemical]

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